Abstract
Cardiovascular disease is stabilizing in high-income countries and has continued to rise in low-to-middle-income countries. Association of lipid profile with lipoprotein lipase gene was studied in case and control subject. The family history, hypertension, diabetes mellitus, smoking and alcohol consumption were the most risk factors for early-onset of coronary heart disease (CHD). Sudanese patients had significantly (P < 0.05) lower TC and LDL-C levels compared to controls. Allele frequency of LPL D9N, N291S and S447X carrier genotype was 4.2%, 30.7% and 7.1%, respectively. We conclude that lipoprotein lipase polymorphism was not associated with the incidence of CHD in Sudan.
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Katia AA, Strunz CMC, Maranha˜o RC, et al. The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids. Arq. Bras. Cardiol. 2007;88(3):267–73.
Jelassi A, Jguirim I, Slimani A, et al. Association between variants of lipoprotein lipase and coronary heart disease in a Tunisian population. Pathol. Biol. (Paris) 2012;60(3):180–4.
Wittrup HH, Tybjaerg-Hansen A, Nordestgaard BG. Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease: a meta-analysis. Circulation 1999;99(22):2901–7.
Musa HH, Tyrab EM, AbdelHamid MM, et al. Charcterization of lipid profile in coronary heart disease patients in Sudan. Indian Heart J. 2013;65:232–3.
Reymer PWA, Gagne SE, Groenemeyer BE, et al. A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL levels in premature atherosclerosis. Nat. Genet. 1995;10:28–33.
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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Hamid, M.M.A., Ahmed, S., Salah, A. et al. Association of lipoprotein lipase gene with coronary heart disease in Sudanese population. J Epidemiol Glob Health 5, 405–407 (2015). https://doi.org/10.1016/j.jegh.2015.04.007
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DOI: https://doi.org/10.1016/j.jegh.2015.04.007