Abstract
Malaysia has abundant sources of drinking water from river and groundwater. However, rapid developments have deteriorated quality of drinking water sources in Malaysia. Heavy metal studies in terms of drinking water, applications of health risk assessment and bio-monitoring in Malaysia were reviewed from 2003 to 2013. Studies on heavy metal in drinking water showed the levels are under the permissible limits as suggested by World Health Organization and Malaysian Ministry of Health. Future studies on the applications of health risk assessment are crucial in order to understand the risk of heavy metal exposure through drinking water to Malaysian population. Among the biomarkers that have been reviewed, toenail is the most useful tool to evaluate body burden of heavy metal. Toenails are easy to collect, store, transport and analysed. This review will give a clear guidance for future studies of Malaysian drinking water. In this way, it will help risk managers to minimize the exposure at optimum level as well as the government to formulate policies in safe guarding the population.
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Azrina A, Khoo HE, Idris MA, Amin I, Razman MR. Major inorganic elements in tap water samples in Peninsular Malaysia. Malays J Nutr 2011;17:271–6.
Food and Agricultural Organization of the United Nations (FAO). FAO’s information system on water and agriculture Malaysia. <http://www.fao.org/nr/water/aquastat/countries_regions/malaysia/index.stm>; 2010 [Retrieved June 20, 2013].
Puncak Niaga Sdn. Bhd. (PNSB). Water treatment. <http://www.puncakniaga.com.my/pnhb2/index.php/core-businesses/intro-on-landing-pg-water/water-treatment>; 2013 [Retrieved July 18, 2014].
Spritzer Bhd. Our Products. <http://www.spritzer.com.my/products/>; 2014 [Retrieved July 18, 2014].
International Bottled Water Association (IBWA). Types of water – bottled. <http://www.bottledwater.org/types/bottled-water>; 2014 [Retrieved July 17, 2014].
Chiba M, Shinohara A, Sekine M, Hiraishi S. Drinking water quality from the aspect of element concentrations. J Radioanal Nucl Chem 2006;269:519–26.
Aini MS, Fakhrul-Razi A, Mumtazah O, Chen JM. Malaysian households’ drinking water practices: a case study. Int J Sustain Dev World Ecol 2007;14:503–10.
Azlan A, Khoo HE, Idris MA, Amin I, Razman MR. Consumption patterns and perception on intake of drinking water in Klang Valley, Malaysia. Pak J Nutr 2012;11:584–90.
Lembaga Air Perak (LAP). Type of treatment plant process. Lembaga Air Perak; 2013.
Ong C, Ibrahim S, Gupta BS. A survey of tap water quality in Kuala Lumpur. Urban Water J 2007;4:29–41.
National Water Service Council (NWSC). Treatment plant design capacity and production 2012–2013. <http://www.span.gov.my/index.php?option=com_content&view=article&id=763&Itemid=418&lang=en>; 2013 [Retrieved July 17, 2014].
Air Kelantan Sdn. Bhd. (AKSB). Information on water treatment plant and treatment system until December 2013. Air Kelantan Sdn. Bhd.; 2013.
Forum Air Malaysia (FAM). Kaedah rawatan air. <http://www.forumair.org.my/v1/index.php?option=com_content&view=article&id=86:kaedah-perawatan-air-perawatan-sebelum-pengklorinan&catid=41:consumer-education&Itemid=78>; 2010 [Retrieved July 18, 2014].
Fu F, Wang Q. Removal of heavy metal ions from wastewaters: a review. J. Environ Manage 2011;92:407–18.
United State Environment Protection Agency (USEPA). Wastewater technology fact sheet – ozone disinfection. <http://water.epa.gov/scitech/wastetech/upload/2002_06_28_mtb_ozon.pdf>; 1999 [Retrieved July 21, 2014].
Mohan D, Pittman Jr CU. Arsenic removal from water/wastewater using adsorbents-a critical review. J Hazard Mater 2007;142:1–53.
Syarikat Bekalan Air Selangor (SYABAS). Pipe length and material. Syarikat Bekalan Air Selangor; 2013.
Air Kelantan Sdn. Bhd. (AKSB). Raw water and treated water pipe length. Air Kelantan Sdn. Bhd.; 2013.
Lembaga Air Perak (LAP). Pipe Length and material till November 2013. Lembaga Air Perak; 2013.
SAJ Holdings. List of specification: pipe & specials. <http://www.saj.com.my/V2/Material_Spec.php?s_mat=2>; 2012 [Retrieved July 21, 2014].
World Health Organization (WHO). Health aspect of plumbing. <http://www.who.int/water_sanitation_health/publications/plumbinghealthasp.pdf>; 2006 [Retrieved July 21, 2014].
Syarikat Air Negeri Sembilan (SAINS). Pipe material. Syarikat Air Negeri Sembilan; 2014.
Kavcar P, Sofuoglu A, Sofuoglu SC. A health risk assessment for exposure to heavy metal via drinking water ingestion pathway. Int J Hyg Environ Health 2009;212: 216–27.
Buchet JP, Lison D. Clues and uncertainties in the risk assessment of arsenic in drinking water. Food Chem Toxicol 2000;38:81–5.
Kioko KJ, Obiri JF. Household attitudes and knowledge on drinking water enhance water hazards in peri-urban communities in Western Kenya. Jàmbá J Disaster Risk Stud 2012;4:1–5.
Karavoltsos S, Sakellari A, Mihopoulos N, Dassenakis M, Scoullos MJ. Evaluation of the quality of drinking water in regions of Greece. Desalination 2008;224:317–29.
Khan S, Shahnaz M, Jehan N, Rehman S, Shah MT, Din I. Drinking water quality and human health risk in Charsadda district, Pakistan. J Clean Prod 2013;60:93–101.
He J, Charlet L. A review of arsenic presence in China drinking water. J Hydrol 2013;492:79–88.
Farizwana MRS, Mazrura S, Zurahanim FA, AhmadRohi G. Determination of aluminium and physicochemical parameters in the palm oil estates water supply at Johor, Malaysia. J Environ Public Health 2010:1–7.
Malaysian Ministry of Health (MMOH). National drinking water quality standard, Engineering Services Division, Ministry of Health, Malaysia. <http://kmam.moh.gov.my/public-user/drinking-water-quality-standard.html>; 2009 [Retrieved May 17, 2013].
Barkatt A, Pulvirenti AL, Adel-Hadadi MA, Viragh C, Senftle FE, Thorpe AN, et al. Composition and particle size of superparamagnetic corrosion products in tap water. Water Res 2009;43:3319–25.
Cambridge Plumbing System Ltd. (CPSL). Corrosion and its causes. <http://www.cambridgeplumbing.com/corrosion.html>; 2010 [Retrieved July 21, 2014].
Chiron N, Guilet R, Deydier E. Adsorption of Cu (II) and Pb (II) onto a grafted silica: isotherms and kinetic models. Water Res 2003;37:3079–86.
Sukumar A. Human nails as a biomarker of element exposure. In: Ware GW, Nigg HN, Doerge DR, editors. Reviews of environmental contamination and toxicology. New York: Springer; 2006. p. 141–77.
Kakkar P, Jaffery FN. Biological markers for metal toxicity. Environ Toxicol Pharmacol 2005;19:335–49.
Housecroft CE, Sharpe AG. The trace metal of life. Inorganic Chemistry. Madrid: Pearson; 2005, p. 830–833.
Rajan S, Nurul NMF, Appukutty M, Ramasamy K. Effects of climate changes on dissolved heavy metal concentrations among recreational park tributaries in Pahang, Malaysia. Biomed Res 2012;23:23–30.
Ouyang Y, Higman J, Thompson J, O’Toole T, Campbell D. Characterization and spatial distribution of heavy metal in sediment from Cedar and Ortega Rivers subbasin. J Contam Hydrol 2002;54:19–35.
Pirsaheb M, Khosravi T, Sharafi K, Babajani L, Rezaei M. Measurement of heavy metals concentration in drinking water from source to consumption site in Kermanshah, Iran. World Appl Sci J 2013;21:416–23.
Beckett WS, Nordberg GF, Clarkson TW. Routes of exposure, dose, and metabolism of metals. In: Fowler BA, Nordberg GF, Nordberg M, Friberg L, editors. Handbook on the toxicology of metals, 3rd ed. 2007. p. 39–64.
Cornelis R, Nordberg M. General chemistry, sampling, analytical methods, and speciation. In: Fowler BA, Nordberg GF, Nordberg M, Friberg L, editors. Handbook on the toxicology of metals, 3rd ed. 2007. p. 11–38.
Caceres DD, Pinoa P, Montesinosc N, Atalah E, Amigod H, Loomis D. Exposure to inorganic arsenic in drinking water and total urinary arsenic concentration in a Chilean population. Environ Res 2005;98:151–9.
Xu P, Huang S, Wang ZA, Lagos G. Daily intakes of copper, zinc and arsenic in drinking water by population of Shanghai, China. Sci Total Environ 2006;362:50–5.
World Health Organization (WHO). Geneva: guidelines for drinking-water quality, 3rd ed. Incorporating the first and second addenda, vol. 1. World Health Organization (WHO). <http://www.who.int/water_sanitation_health/dwq/gdwq0506.pdf>; 2008 [Retrieved May 17, 2013].
Khoo HE, Azlan A, Idris MA, Ismail A, Razman MR. Evaluation of selected metal elements in commercial drinking water and tap water in Peninsular Malaysia. Malays J Health Sci 2011;9:5–11.
Nalatambi S. Determination of metals in tap water using atomic absorption spectrometry: a case study in Bandar Sunway residential area. Sunway Acad J 2009;6:33–46.
Lim CS, Shaharuddin MS, Sam WY. Risk assessment of exposure to lead in tap water among residents of Seri Kembangan, Selangor State, Malaysia. Global J Health Sci 2013;5:1–12.
Nor ZZ. Health risk assessment of lead exposure in drinking water among residents of Felda Palong, Negeri Sembilan [dissertation]. Universiti Putra Malaysia; 2012.
Maisarah Z. Health risk assessment of lead exposure in drinking water in two villages in Kuala Terengganu, Terengganu [dissertation]. Universiti Putra Malaysia; 2012.
Department of Environment, Malaysia. Environmental quality report 2013. <https://enviro.doe.gov.my/view.php?id=15791> [Retrieved January 30, 2015].
Kim EJ, Herrera JE, Huggins D, Braam J, Koshowski S. Effect of pH on the concentrations of lead and trace contaminants in drinking water: a combined batch, pipe loop and sentinel home study. Water Res 2011;45: 2763–74.
Aminah AH. Health risk assessment of aluminium residue exposure in drinking water among residents in two villages in Kuala Terengganu, Terengganu [dissertation]. Universiti Putra Malaysia; 2012.
Rahimah S. Health risk assessment of residual aluminium in drinking water among settlers of Felda Palong 4,5,6,7 and 8, Negeri Sembilan [dissertation]. Universiti Putra Malaysia; 2012.
Mohd Aizuddin A. Health risk assessment of exposure to residual aluminium (Al) in drinking water of residents in Kamunting Perak [dissertation]. Universiti Putra Malaysia; 2012.
Nur AMM. Risk assessment of aluminium residue concentration in daily intake by human from drinking tap water, Felda Jenderak Selatan, Temerloh, Pahang [dissertation]. Universiti Putra Malaysia; 2012.
Qaiyum MS, Shaharudin MS, Syazwan AI, Muhaimin A. Health risk assessment after exposure to aluminium in drinking water between two different villages. J Water Resour Prot 2011;3:268–74.
Dzulfakar MA, Shaharuddin MS, Muhaimin AA, Syazwan AI. Risk assessment of aluminum in drinking water between two residential areas. Water 2011;3:882–93.
Azmir A. Kepekatan aluminium dalam air minum dan penilaian risiko kesihatan di dua buah petempatan di Selangor [dissertation]. Universiti Putra Malaysia; 2003.
Nora A. Kepekatan aluminium dalam air minum dan penilaian risiko kesihatan di dua buah petempatan di Johor [dissertation]. Universiti Putra Malaysia; 2003.
Jamaludin N, Sham SM, Norkhadijah S, Ismail S. Health risk assessment of nitrate exposure in well water of residents. Am J Appl Sci 2013;10:442–8.
Azwan M, Zawawi M, Yusoff MK, Hussain H, Nasir S. Nitrate-nitrogen concentration variation in groundwater flow. IEM J 2010;71:2–10.
Air Kelantan Sdn. Bhd. (AKSB). Consumer information. <http://airkelantan.com.my/maklumat-pengguna/>; 2014 [Retrieved July 18, 2014].
Kato M, Onuma S, Katoa Y, Thangac ND, Yajima I, Hoque MZ, et al. Toxic elements in well water from Malaysia. Toxicol Environ Chem 2010;92:1609–12.
Rahim BEE, Yusoff I, Samsudin AR, Yaacob WZW, Rafek AGM. Deterioration of groundwater quality in the vicinity of an active open-tipping site in West Malaysia. Hydrogeol J 2010;18(4):997–1006.
Islami N, Taib SH, Yusoff I, Ghani AA. Integrated geoelectrical resistivity, hydrochemical and soil property analysis methods to study shallow groundwater in the agriculture area, Machang, Malaysia. Environ Earth Sci 2012;65:699–712.
Huang X, Sillanpää M, Duo BU, Gjessing ET. Water quality in the Tibetan Plateau: metal contents of four selected rivers. Environ Pollut 2008;156:270–7.
Spritzer Bhd. Annual report 2012. <http://www.spritzer-commy/html/ir_annual_reportsaspx> [Retrieved July 1, 2013].
Azrina A, Khoo HE, Idris MA, Amin I, Razman MR. Evaluation of minerals content of drinking water in Malaysia. Sci World J 2011:1–10.
Aris AZ, Kam RCY, Lim AP, Praveena SM. Concentration of ions in selected bottled water samples sold in Malaysia. Appl Water Sci 2013;3(1):67–75.
Gamble MV, Liu X, Ahsan H, Pilsner JR, Ilievski V, Slavkovich V, et al. Folate, homocysteine and arsenic metabolism in arsenic-exposed individuals in Bangladesh. Environ Health Perspect 2005;113:1683–8.
Sun G, Xu Y, Li X, Jin Y, Li B, Sun X. Urinary arsenic metabolites in children and adults exposed to arsenic in drinking water in Inner Mongolia, China. Environ Health Perspect 2007;115(4):648–52.
Karagas MR, Tosteson TD, Blum J, Klaue B, Weiss JE, Stannard V, et al. Measurement of low levels of arsenic exposure: a comparison of water and toenail concentrations. Am J Epidemiol 2000;152(1):84–90.
Aitio A, Bernard A, Fowler BA, Nordberg GF. Biological monitoring and biomarkers. In: Fowler BA, Nordberg GF, Nordberg M, Friberg L, editors. Handbook on the toxicology of metals, 3rd ed. 2007. p. 65–78.
Marchiset-Ferlay N, Savanovitch C, Sauvant-Rochat MP. What is the best biomarker to assess arsenic exposure via drinking water? Environ Int 2012;39(1):150–71.
Adair BM, Hudgens EE, Schmitt M, Calderon RL, Thomas DJ. Total arsenic concentrations in toenails quantified by two techniques provide a useful biomarker of chronic arsenic exposure in drinking water. Environ Res 2006;101(2):213–20.
Hall M, Chen Y, Ahsan H, Slavkovich V, van Geen A, Parvez F. Blood arsenic as a biomarker of arsenic exposure: results from a prospective study. Toxicology 2006;225(2–3): 225–33.
Mandal BK, Ogra Y, Suzuki KT. Speciation of arsenic in human nail and hair from arsenic-affected area by HPLC-inductively coupled argon plasma mass spectrometry. Toxicol Appl Pharmacol 2003;189(2):73–83.
Abdulrahman FI, Akan JC, Chellube ZM, Waziri M. Levels of heavy metals in human hair and nail samples from Maiduguri Metropolis, Borno State, Nigeria. World Environ 2012;2(4): 81–9. https://doi.org/10.5923/j.env.20120204.05.
Phan K, Sthiannopkao S, Kim KW. Surveillance on chronic arsenic exposure in the Mekong River basin of Cambodia using different biomarkers. Int J Hyg Environ Health 2011;215(1):51–8. https://doi.org/10.1016/j.ijheh.2011.07.002.
Samanta G, Sharma R, Roychowdhury T, Chakraborti D. Arsenic and other elements in hair, nails, and skin-scales of arsenic victims in West Bengal, India. Sci Total Environ 2004;326(1–3):33–47.
Schulte PA. The use of biomarkers in surveillance, medical screening, and intervention. Mutat Res 2005;592(1–2): 155–63.
Gault AG, Rowland HAL, Charnock JM, Wogelius RA, Gomez-Morilla I, Vong S, et al. Arsenic in hair and nails of individuals exposed to arsenic-rich groundwaters in Kandal province, Cambodia. Sci Total Environ 2008;393(1): 168–76. https://doi.org/10.1016/j.scitotenv.2007.12.028.
Sukumar A, Subramanian R. Relative element levels in the paired samples of scalp hair and fingernails of patients from New Delhi. Sci Total Environ 2007;372(2–3):474–9.
Esteban M, Castan˜o A. Non-invasive matrices in human biomonitoring: a review. Environ Int 2009;35(2):438–49.
LaKind JS, Barraj L, Tran N, Aylward L. Environmental chemicals in people: Challenges in interpreting biomonitoring information. J Environ Health 2008;70(9):61–4.
Del Razo LM, Styblo M, Cullen WR, Thomas DJ. Determination of trivalent methylated arsenicals in biological matrices. Toxicol Appl Pharmacol 2001;174(3):282–93.
Nermell B, Lindberg AL, Rahman M, Berglund M, Persson LA, Arifeen SE, et al. Urinary arsenic concentration adjustment factors and malnutrition. Environ Res 2008;106(2):212–8.
Schmitt MT, Schreinemachers D, Wu K, Ning Z, Zhao B, Le XC, et al. Human nails as a biomarker of arsenic exposure from well water in Inner Mongolia: comparing atomic fluorescence spectrometry and neutron activation analysis. Biomarkers 2005;10(2–3):95–104.
Mahata J, Basu A, Ghoshal S, Sarkar JN, Roy AK, Poddar G, et al. Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal, India. Mutat Res 2003;534(1–2):133–43.
Slotnick MJ, Nriagu JO. Validity of human nails as a biomarker of arsenic and selenium exposure: a review. Environ Res 2006;102(1):125–39.
Nowak B, Chmielnicka J. Relationship of lead and cadmium to essential elements in hair, teeth, and nails of environmentally exposed people. Ecotoxicol Environ Saf 2000;46(3):265–74.
Srogi K. Hair analysis for monitoring environmental pollution and the resulting human exposure to trace metals: an overview. Environ Risques Santà 2006;5(5):391–405.
Harkins DK, Susten AS. Hair analysis: exploring the state of the science. Environ Health Perspect 2003;111(4):576–8.
Slotnick MJ, Meliker JR, AvRuskin GA, Ghosh D, Nriagu JO. Toenails as a biomarker of inorganic arsenic intake from drinking water and foods. J Toxicol Environ Health A 2007;70(2):148–58.
Hinwood AL, Sim MR, Jolley D, de Klerk N, Bastone EB, Gerostamoulos J, et al. Hair and toenail arsenic concentrations of residents living in areas with high environmental arsenic concentrations. Environ Health Perspect 2003;111(2):187–93.
Brima EI, Haris PI, Jenkins RO, Polya DA, Gault AG, Harrington CF. Understanding arsenic metabolism through a comparative study of arsenic levels in the urine, hair and fingernails of healthy volunteers from three unexposed ethnic groups in the United Kingdom. Toxicol Appl Pharmacol 2006;216(1):122–30.
Minjeong K, Kisok K. Biomonitoring of lead and cadmium in the hair and fingernails of elderly Korean subjects. Biol Trace Elem Res 2011;143(2):794–802. https://doi.org/10.1007/s12011-010-8942-4.
Mordukhovich I, Wright RO, Hu H, Amarasiriwardena C, Baccarelli A, Litonjua A, et al. Associations of toenail arsenic, cadmium, mercury, manganese, and lead with blood pressure in the normative aging study. Environ Health Perspect 2012;120(1):98–104. https://doi.org/10.1289/ehp.1002805.
Were FH, Njue W, Murungi J, Wanjau R. Use of human nails as bio-indicators of heavy metals environmental exposure among school age children in Kenya. Sci Total Environ 2008;393(2–3):376–84. https://doi.org/10.1016/j.scitotenv.2007.12.035.
Ab Razak NH, Praveena SM, Hashim Z. Toenail as a biomarker of heavy metal exposure via drinking water: a systematic review. Rev Environ Health 2015;30(1):1–7.
Spickett J, Katscherian D, Goh YM. A new approach to criteria for health risk assessment. Environ Impact Asses 2012;32(1):118–22.
Ma HW, Hung ML, Chen PC. A systemic health risk assessment for the chromium cycle in Taiwan. Environ Int 2007;33(2):206–18.
Falk-Filipsson A, Hanberg A, Victorin K, Warholm M, Wallén M. Assessment factors-applications in health risk assessment of chemicals. Environ Res 2007;104(1):108–27.
Sobus JR, Tan YM, Pleil JD, Sheldon LS. A biomonitoring framework to support exposure and risk assessments. Sci Total Environ 2011;409(22):4875–84. https://doi.org/10.1016/j.scitotenv.2011.07.046.
Manno M, Viau C, John C, Claudio C, Larry L, Antonio M, et al. Biomonitoring for occupational health risk assessment (BOHRA). Toxicol Lett 2010;192(1):3–16. https://doi.org/10.1016/j.toxlet.2009.05.001.
Egeghy PP, Quackenboss JJ, Catlin S, Ryan PB. Determinants of temporal variability in NHEXAS-Maryland environmental concentrations, exposures, and biomarkers. J Expo Sci Environ Epidemiol 2005;15(5):388–97.
Thomas KW, Dosemeci M, Coble JB, Hoppin JA, Sheldon LS, Chapa G. Assessment of a pesticide exposure intensity algorithm in the Agricultural Health Study. J Expo Sci Environ Epidemiol 2009;20(6):559–69.
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Razak, N.H.A., Praveena, S.M., Aris, A.Z. et al. Drinking water studies: A review on heavy metal, application of biomarker and health risk assessment (a special focus in Malaysia). J Epidemiol Glob Health 5, 297–310 (2015). https://doi.org/10.1016/j.jegh.2015.04.003
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DOI: https://doi.org/10.1016/j.jegh.2015.04.003