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Predictors of long-term survival in patients with gallbladder cancer

  • Original Articles
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Journal of Gastrointestinal Surgery

Abstract

The aim of this study was to examine the predictors of long-term survival (>24 months) in patients with gall bladder cancer. A retrospective review of 117 cases of gall bladder cancer resected between 1989 and 2000. The resections included 80 simple cholecystectomies and 37 extended procedures. Patients with survival >24 months (n=44) were compared with those having survival <24 months (n=73) for 17 prognostic factors. Overall median survival was 16 months with a 5-year survival of 27%. T status (P=.000) and adjuvant chemoradiotherapy (P=.001) were independent predictors of long-term survival. Survival advantage was seen in T3N+ve disease (P=.007) with extended procedures. Complete (R0) resection was attained in 30 patients with a 5-year survival advantage of 30% as compared with incomplete (R1) resection (P=.0002). Adjuvant chemoradiotherapy improved survival in simple cholecystectomy group (P=.0008) but no advantage was seen after extended procedures. Stage III (P=.001) and node-positive disease (P=.0005) had significant benefit with adjuvant therapy. Poor differentiation and vascular invasion were associated with poor long-term survival. R0 resection was associated with prolonged survival. Extended procedures improved survival in patients with T3N+ve disease. Addition of chemoradiotherapy made significant improvement in long-term survival in stage III and node-positive lesions and in patients undergoing simple cholecystectomy. R0 resection predicted long-term survival in gall bladder cancer. T3 N+ve disease had better survival after extended procedures. Adjuvant chemoradiotherapy improved survival in stage III and node-positive disease. Poor differentiation and vascular invasion were adverse predictors of survival.

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Authors and Affiliations

  1. From the Department of Surgical Gastroenterology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, 226014, Lucknow, India

    Palat Balachandran M.S., M.Ch., Shaleen Agarwal M.S., M.Ch., Ashok Kumar M.S., M.Ch., Sadiq S. Sikora M.S. (F.A.C.S.), Rajan Saxena M.S. & Vinay K. Kapoor M.S. (F.A.C.S., F.R.C.S., F.A.C.G., Professor and Head)

  2. the Department of Pathology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India

    Narendra Krishnani M.D.

  3. the Department of Biostatistics, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India

    Chandra M. Pandey Ph.D.

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  1. Palat Balachandran M.S., M.Ch.
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  2. Shaleen Agarwal M.S., M.Ch.
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  3. Narendra Krishnani M.D.
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  4. Chandra M. Pandey Ph.D.
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  5. Ashok Kumar M.S., M.Ch.
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  6. Sadiq S. Sikora M.S.
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  7. Rajan Saxena M.S.
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  8. Vinay K. Kapoor M.S.
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Correspondence to Vinay K. Kapoor M.S..

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Balachandran, P., Agarwal, S., Krishnani, N. et al. Predictors of long-term survival in patients with gallbladder cancer. J Gastrointest Surg 10, 848–854 (2006). https://doi.org/10.1016/j.gassur.2005.12.002

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  • DOI: https://doi.org/10.1016/j.gassur.2005.12.002

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