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Does the intraoperative peritoneal lavage cytology add prognostic information in patients with potentially curative gastric resection?

  • 2005 SSAT Annual Meeting
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Peritoneal recurrence is the foremost pattern of failure after potentially curative resection for gastric cancer. Our aim was to evaluate the prognostic value of intraperitoneal free cancer cells (IFCCs) in peritoneal lavage of patients who underwent potentially curative resection for gastric carcinoma. Two hundred twenty patients with gastric cancer stage I, II, or III were prospectively evaluated with peritoneal lavage and cytologic examination. Aspirated fluid from the abdominal cavity was centrifuged and subjected to Papanicolaou staining. The mean age was 60.9 years (range, 21–89 years), and 63.6% were men. IFCCs were detected in 6.8% of the patients; suspicious in 2.7%, and negative in 84.5%. No judgment could be given in 5.9% of the cases. Invasion of the gastric serosa (pT3) was observed in all positive cytology patients. Patients with IFCCs had a mean survival time of 10.5 months, while those with negative IFCC had a mean survival time of 61 months (P = 0.00001). There was no correlation between the presence of IFCCs and tumor size, histology, pN, or tumor site. Our conclusions are that (1) positive cytology indicates a poor prognosis in patients who underwent potentially curative gastric resection and (2) peritoneal lavage cytology improves staging in assessing these patients and may alter their therapeutic approach.

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Authors and Affiliations

  1. Department of Gastroenterology, University of São Paulo, São Paulo, Brazil

    Ulysses Ribeiro Jr. M.D., Adriana V. Safatle-Ribeiro M.D., Bruno Zilberstein M.D., Donato Mucerino M.D., Osmar Kenji Yagi M.D., Cla’udio Caldas Bresciani M.D., Carlos Eduardo Jacob M.D., Kyioshi Iryia M.D. & Joaquim Gama-Rodrigues M.D.

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  1. Ulysses Ribeiro Jr. M.D.
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  2. Adriana V. Safatle-Ribeiro M.D.
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  3. Bruno Zilberstein M.D.
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  4. Donato Mucerino M.D.
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  5. Osmar Kenji Yagi M.D.
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  6. Cla’udio Caldas Bresciani M.D.
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  7. Carlos Eduardo Jacob M.D.
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  8. Kyioshi Iryia M.D.
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  9. Joaquim Gama-Rodrigues M.D.
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Corresponding author

Correspondence to Ulysses Ribeiro Jr. M.D..

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Supported by a travel grant from the Foundation of Support to the Research of the State of São Paulo (FAPESP) Foundation.

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Ribeiro, U., Safatle-Ribeiro, A.V., Zilberstein, B. et al. Does the intraoperative peritoneal lavage cytology add prognostic information in patients with potentially curative gastric resection?. J Gastrointest Surg 10, 170–177 (2006). https://doi.org/10.1016/j.gassur.2005.11.001

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  • DOI: https://doi.org/10.1016/j.gassur.2005.11.001

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