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Pancreas-sparing duodenectomy is effective management for familial adenomatous polyposis

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Duodenal adenocarcinoma remains the leading cause of cancer death in familial adenomatous polyposis patients following colectomy. Stratification based on Spigelman’s criteria provides a means for determining therapy. Spigelman stage IV patients have been selected for pancreas-sparing duodenectomy. Twentyone patients underwent resection between 1992 and 2004, with a mean age of 58 ±11 years. The mean time from colectomy to duodenectomy was 27 ±13 years. Invasive cancer was found in the distal duodenum in one patient. Operative time averaged 327 ±61 minutes with a mean blood loss of 503 ± 266 ml. There was no mortality, and eight patients (38%) had 14 complications: six (29%) with delayed gastric emptying, four (19%) with biliary/pancreatic anastomotic leak, one with pancreatitis, and one with wound infection. There were two reoperations: one for delayed gastric emptying and one for an early biliary leak. Mean length of stay was 15 ±10 days. Two late complications occurred: a stomal ulcer and an intestinal obstruction at 48 and 24 months, respectively. Mean follow-up was 79 months (range, 3–152 months). Two patients developed polyps in the advanced jejunal limb and were endoscopically treated. Pancreassparing duodenectomy represents a definitive treatment for advanced duodenal polyposis and can obviate the need for pancreaticoduodenectomy.

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Authors and Affiliations

  1. Department of General Surgery, Cleveland Clinic Foundation, Cleveland, Ohio

    Richard Mackey M.D., R. Matthew Walsh M.D., Raphael Chung M.D., Nancy Brown R.N. & Andrew Smith M.B.B.S.

  2. Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio

    James Church M.D.

  3. Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio

    Carol Burke M.D.

Authors
  1. Richard Mackey M.D.
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  2. R. Matthew Walsh M.D.
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  3. Raphael Chung M.D.
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  4. Nancy Brown R.N.
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  5. Andrew Smith M.B.B.S.
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  6. James Church M.D.
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  7. Carol Burke M.D.
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Correspondence to R. Matthew Walsh M.D..

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Mackey, R., Walsh, R.M., Chung, R. et al. Pancreas-sparing duodenectomy is effective management for familial adenomatous polyposis. J Gastrointest Surg 9, 1088–1093 (2005). https://doi.org/10.1016/j.gassur.2005.07.021

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  • DOI: https://doi.org/10.1016/j.gassur.2005.07.021

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