Abstract
Natural products have been the most valuable source of chemical compounds in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. Brazil has an exceptionally rich biodiversity, and a valuable source of secondary metabolites that can be useful for the development of bioproducts. Ipomoea species, Convolvulaceae, are mostly found in tropical and sub-tropical regions, including South America and many are used for nutritional and medicinal purposes. Ipomoea procumbens Mart. & Choisy is endemic from South America, and this is the first study reported on the chemical composition and biological activities of this species. The present work reports the tentatively identification of natural products present in the extracts using a high performance liquid chromatography-high resolution mass spectrometry method. Additionally, the antioxidant and antifungal biological activities of the leaves, roots and steams extracts and fractions of this species were evaluated. While for the antioxidant activity the hydromethanol fractions (leaves, stem and roots) were more active, the methanol fractions of leaves and stem provided better results for the antifungal assay.
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SB (MSc student) contributed in running the laboratory work, extractions, acquisition and analysis of the data. MV supervised laboratory work, analyzed data and drafted the paper. MLZ and KF contributed to antioxidant biological studies and aided in the drafting of the paper. GML contributed to chromatographic analysis and aided in the drafting of the paper. NSM and AMFA contributed to antifungal biological studies. MCMY contributed to plant collection, plant identification and herbarium confection. SM and VSB designed the study and contributed to critical reading of the manuscript. All the authors have read the final manuscript and approved the submission.
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Batiga, S., Valli, M., Zeraik, M.L. et al. Chemical composition and biological properties of Ipomoea procumbens. Rev. Bras. Farmacogn. 29, 191–197 (2019). https://doi.org/10.1016/j.bjp.2018.08.010
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DOI: https://doi.org/10.1016/j.bjp.2018.08.010