Abstract
Salvia lachnocalyx Hedge, Lamiaceae, is an endemic sage which grows naturally in the Fars Province of Iran. The phytochemical analyses of the roots of S. lachnocalyx led to the isolation of five known diterpenoids: ferruginol (1), taxodione (2), sahandinone (3), 4-dehydrosalvilimbinol (4) and labda-7,14-dien-13-ol (5). Their chemical structures were elucidated using one (1H and 13C) and two dimensional (COSY, HSQC and HMBC) NMR spectroscopic data as well as electron impact mass spectra. The cytotoxicity of the purified compounds was evaluated against three human cancer cell lines; MOLT-4 (acute lymphoblastic leukemia), HT-29 (colorectal adenocarcinoma) and MCF7 (breast adenocarcinoma) and all of the isolated compounds showed considerable cytotoxic activity against these cell lines. Compounds 2 and 3 (IC50 range: 0.41–3.87 μg/ml) with endocyclic α,β-unsaturated carbonyl functional group, exhibited the highest cytotoxic activities compared to the other compounds (IC50 range: 6.85–17.23 μg/ml). In conclusion, compounds 2 and 3 are presented as compounds that deserve further investigation of their biological activities.
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ARJ: Supervised the studies in analyzing natural products and determining the structures of natural products, helped in writing the paper, HHM: PhD Student; a part of his dissertation, OF: Supervised the studies in assessment of biological activity, contributed to the preparation and writing the manuscript; BS: Performed NMR spectroscopy and scientific advising; ITB: Scientific supporting the project and helping in editing the manuscript.
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Mirzaei, H.H., Firuzi, O., Schneider, B. et al. Cytotoxic diterpenoids from the roots of Salvia lachnocalyx. Rev. Bras. Farmacogn. 27, 475–479 (2017). https://doi.org/10.1016/j.bjp.2017.01.009
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DOI: https://doi.org/10.1016/j.bjp.2017.01.009