Abstract
A new isoflavonoid glycoside, iridin A (9), along with eight known isoflavonoids: irilone 4′-methyl ether (1), irilone (2), irisolidone (3), irigenin S (4), irigenin (5), irilone 4′-O-β-d-glucopyranoside (6), iridin S (7), and iridin (8) were separated from Iris × germanica L., Iridaceae, rhizomes. The structural elucidation of these flavonoids was achieved with the aid of extensive spectroscopic techniques and comparing with the published data. They were estimated for their α-amylase and 1, 1-diphenyl-2-picrylhydrazyl inhibitory capacities. Compounds 3, 5, and 9 showed α-Amylase inhibitory activities with % inhibition 70.8, 67.5, and 70.5, respectively compared to acarbose (a reference α-Amylase inhibitor). Moreover, 9 exhibited moderate antioxidant activity with IC50 8.91 μM.
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AIMK collected and extracted of the plant material, also helped in the interpretation of the spectral data. GAM and SRMI contributed in carrying out the laboratory work, interpretation of the spectroscopic data, and writing the manuscript. AMA carried out the biological assays and interpreted the results. GAM and SRMI have revised and approved the submission.
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Ibrahim, S., Al-Ahdal, A., Khedr, A. et al. Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes. Rev. Bras. Farmacogn. 27, 170–174 (2017). https://doi.org/10.1016/j.bjp.2016.10.001
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DOI: https://doi.org/10.1016/j.bjp.2016.10.001