Abstract
Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 μg TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 μg/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 μg/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 μg/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.
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LB, PPPV and YBF collected the plant samples and organized the botanical identification and confection of herbarium specimens. JT performed the antioxidant assays and drafted the paper. ID organized the anti-proliferative test. LH and PMik did the UHPLC-MS/MS analysis. PMar provided statistical analysis of gained data. PVD, BL, JH and OL contributed to critical reading of the manuscript. LK designed the study, supervised the laboratory work and revised the final version of the paper. All the authors have read the final manuscript and approved the submission.
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Tauchen, J., Bortl, L., Huml, L. et al. Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon. Rev. Bras. Farmacogn. 26, 728–737 (2016). https://doi.org/10.1016/j.bjp.2016.03.016
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DOI: https://doi.org/10.1016/j.bjp.2016.03.016