Neuropharmacological effects of the ethanolic extract of Sida acuta

Abstract

Sida acuta Burm. f., Malvaceae, is regarded as astringent, tonic and useful in treating urinary diseases and blood disorders, bile, liver and as treatment for nervous diseases. Different methods were developed: sodium pentobarbital-induced sleeping time, anxiolytic activity, test for muscle-effects, pentylenetetra-zole (PTZ)-induced seizures, effect on normal body temperature. All experiments were performed in an isolated room with 12/12 h light/dark cycles at 22 ± 1 ° C. The effects described in this work for Sida acuta are according to what is known in traditional medicine, where is used as sedative agent. At the higher doses used in this work ( 500 and 1000 mg/kg), the Sida acuta extract reduced the latency time (Tl ) and increased the sleeping time (T2) induced by pentobarbital, indicating a sedative and hypnotic effect of the plant’s extract. The extract of Sida acuta shows an increase in open arm exploration (anxiolytic activ-ity). Results obtained in the rota-rod test showed that only the elevated dose (750 mg/kg) of Sida acuta extract, acutely administered, promotes significant changes, at 60 and 120 min post-administration, in the time of permanence in the rod. The ethanolic extract from the leaves and stems of Sida acuta, causes effects on the central nervous system in experimental animals.

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Acknowledgements

Dr. Norman Fransworth (RIP) for giving us information of the database NAPRALERT. Carolina Foundation, University of Antioquia — Colombia and University of Santiago de Compostela — Spain for finance the scholarship of the Prof. Benjumea in the Pharmacology Laboratory of Central Nervous System (GI-1684-USC). CODI Sustainability project 2014–2015.

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The identification and collection of plant material were made by FAG in company of JV and IC. G-B prepared the extracts. The pharmacological evaluation was performed by DMB, AG-S and JAFThe manuscript was elaborated by DMB All the authors have read the final manuscript and agreed to its submission for appraisal.

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Correspondence to Dora M. Benjumea.

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Benjumea, D.M., Gómez-Betancur, I.C., Vásquez, J. et al. Neuropharmacological effects of the ethanolic extract of Sida acuta. Revista Brasileira de Farmacognosia 26, 209–215 (2016). https://doi.org/10.1016/j.bjp.2015.09.011

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Keywords

  • Anxiolytic activity
  • Anticonvulsant activity
  • Rota rod
  • Sodium pentobarbital-induced sleeping time