Abstract
Acetogenins are secondary metabolites derived from the polyketide pathway and their potential role as chemotaxonomical markers for red algae belonging to the Laurencia complex has been long pointed out. C15 acetogenins from algae are quite different from plant acetogenins: they are usually halogenated, and have an enyne or a bromoallene terminal group. Since they were first reported, laurencin and other algal acetogenins have inspired great curiosity among natural product chemists and also those working with synthesis. This paper reviews the literature about C15 acetogenins, focusing on their distribution, chemical and biological aspects, including their reported biological activities.
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Acknowledgments
The authors thank Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes, Brazil) (TW, ACP and GAZ) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil) (LFOV and CL) for their fellowships. The authors thank Manuela Batista (CCB, UFSC) for the picture used in the graphical abstract.
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All authors contributed in collecting and analyzing data besides drafting parts of the paper. TW (PhD student), ACP (Master student), GAZ (MSc), LFOV (Undergraduate student) and CL (postdoc fellowship) contributed also drawing the structures. MF (Professor) organized the data and contributed to critical reading of the manuscript. All the authors have read the final manuscript and approved the submission.
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Wanke, T., Philippus, A.C., Zatelli, G.A. et al. C15 acetogenins from the Laurencia complex: 50 years of research – an overview. Rev. Bras. Farmacogn. 25, 569–587 (2015). https://doi.org/10.1016/j.bjp.2015.07.027
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DOI: https://doi.org/10.1016/j.bjp.2015.07.027