Abstract
The antimicrobial activity of the myrsinoic acid A isolated from Myrsine coriacea (Sw.) R.Br. ex Roem. Schult., Primulaceae, and a two semi-synthetics derivatives was tested against Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar typhi, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Micrococcus luteus, Candida albicans, Candida krusei and Candida tropicalis. The microdilution method was used for the determination of the minimum inhibitory concentration during evaluation of the antimicrobial activity. The myrsinoic acid A showed no activity against the selected microorganisms but the hydrogenated and acetylated derivatives were active against B. subtilis, E. coli, S. aureus and P. aeruginosa.
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References
Bagalwa, M., Chifundera, K., 2007. Environmental impact evaluation of the stem bark extract of Maesa lanceolata used in Democratic Republic of Congo. J. Ethnopharmacol. 114, 281–284.
Bhandari, U., Jain, N., Ansari, M.N., Pillai, K.K., 2008. Beneficial effect of Embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats. Fitoterapia 79, 351–355.
Burger, M.C.M., De Oliveira, G.S., Menezes, A.C.S., Vieira, P.C., Da Silva, M.F.G.F., Veiga, T.A.M., 2012. Ácido myrsinoico A e derivado: inibidores da fotossíntese in vivo. Quim. Nova 35, 1395–1400.
Cordero, C.P., Gómez-Gonzales, S., León-Acosta, C.J., Morantes-Medina, S.J., Aristiz-abal, F.A., 2004. Cytotoxic activity of five compounds isolated from Colombian plants. Fitoterapia 75, 225–227.
Cruz, A.B., Kazmierczak, K., Gazoni, V.G., Monteiro, E.R., Fronza, L.A., Martins, P., Yunes, R.A., Bürger, C., Tomio, T.A., Freitas, R.A., Malheiros, A., 2013. Bioguided isolation of antimicrobial compounds from Rapane ferruginea and its cytotoxic and genotoxic potential. J. Med. Plants Res. 71, 1323–1329.
Dong, M., Nagaoka, M., Miyazaki, S., Iriye, R., Hirota, M., 1999. 3-Genaryl-4-hydroxy-5-(3′-methyl-2′-butenyl)benzoic acid as an anti-inflammatory compound from Myrsine seguinni. Biosci. Biotechnol. Biochem. 63, 1650–1653.
Filippin, F.B., Gazoni, V.F., Meyre-Silva, C., Yunes, R.A., Malheiros, A., de Souza, M.M., Bürger, C., 2009. In vitro inhibition of acetylcholinesterase by myrsonic acid A. Dement. Neuropsychol. 3, 41.
Gazoni, V.F., (Dissertação de mestrado em ciências farmacêuticas) 2009. Análise fitoquímicae avaliação do efeito anticolinesterásico do extrato e compostos isolados de Rapanea ferrugínea. Universidade do Vale do Itajaí.
Gathuama, J.M., Mbaria, J.M., Wanyamab, J., Kaburia, H.F.A., Mpoke, L., Mwangi, J.N., 2004. Efficacy of Myrsine africana, Albizia anthelmintica and Hilderbrantia sepalosa herbal remedies against mixed natural sheep helminthosis in Samburu district. J. Ethnopharmacol. 91, 7–12.
Hemaiswarya, S., Kruthiventi, A.K., Doble, M., 2008. Synergism between natural products and antibiotics against infectious diseases. Phytomedicine 15, 639–652.
Itoh, S., Narise, A., Tsugane, T., Shimura, S., 2014. Methioninase inhibitor and composition and food or drink containing the same. US Patent 20140308218 Al.
Januário, A.H., Vieira, P.C., Da Silva, M.F.G.F., Fernandes, J.B., 1991. Terpeno-p-hidroxybenzoic acid derivatives from Rapanea umbellata. Phytochemistry 30, 2019–2023.
Januário, A.H., Vieira, P.C., Da Silva, M.F.G.F., Fernandes, J.B., 1992. Dammarane and cycloartane triterpenoids from three Rapanea species. Phytochemistry 34, 1251–1253.
Katuura, E., Waako, P., Tabuti, J.R.S., Bukenga-Ziraba, R., Ogwal-Okeng, J., 2007. Antiplasmodial activity of extracts of selected medicinal plants used by local communities in western Uganda for treatment of malaria. Afr. J. Ecol. 45, 94–98.
Lee, S.W., Mandinova, A., 2011. Approaches to treat cancer using HB-EGF inhibitors such as myrsinoic acid A. WO Patent 2011014257 Al.
Nascimento, G.G.F., Locatelli, J., Freitas, P.C., Silva, G.L., 2000. Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria. Braz. J. Microbiol. 31, 247–256.
Reguero, M.T., Calle, J., Mata, R., 1989. Estudo fitoquímico y actividad biológica de Rapanea guianensis. Rev. Colomb. Cienc. Quím. Farm. 17, 57–61.
Acknowledgments
This work was supported by the FAPESP (grant number 2006/58043-3), CNPq and CAPES by student sponsorships. The authors acknowledge M. F. Freitas by plant identification.
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MCMB and GSOC (PhD students) contributed in collecting plant sample, running the laboratory work, in the synthesis of derivatives, analysis of the data and drafted the paper. APT contributed to biological studies, analysis of the data and drafted the paper.JBF, MFGFS, PCV, ACSM contributed to chromatographic analysis,designed the study, supervised the laboratory work and contributed to critical reading of the manuscript. All the authors have read the final manuscript and approved the submission.
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de Burger, M.C.M., Terezan, A.P., de Oliveira Cunha, G.S. et al. Antimicrobial activity of the myrsinoic acid A from Myrsine coriacea and the semi-synthetic derivatives. Rev. Bras. Farmacogn. 25, 451–454 (2015). https://doi.org/10.1016/j.bjp.2015.07.023
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DOI: https://doi.org/10.1016/j.bjp.2015.07.023