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Crosstalk between contact hypersensitivity reaction and antidepressant drugs

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Abstract

Allergic contact dermatitis is a delayed-type hypersensitivity reaction mediated by hapten-specific T cells. Many cell types, inflammatory mediators and cytokines are involved in this reaction. Contact hypersensitivity is a self-limited reaction and can be regulated at different levels. Because it is known that disturbances in the immune system underpin the onset of depression and that antidepressant drugs have immunomodulatory effects, it can be hypothesized that antidepressants may have some efficacy in the treatment of contact hypersensitivity. There are some reports on the effectiveness of antidepressants in the inhibition of cutaneous sensitization in mice, and the aim of this narrative review is to assess the evidence for the effectiveness of antidepressant drugs in reducing the recurrence of contact hypersensitivity reactions.

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Authors and Affiliations

  1. Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Smętna 12, PL 31-343, Poland

    Katarzyna Curzytek, Marta Kubera, Agnieszka Basta-Kaim, Monika Leśkiewicz, Bogusława Budziszewska & Władysław Lasoń

  2. Department of Medical Biology, Jagiellonian University Medical College, Kraków, Kopernika 12, PL 31-034, Poland

    Marian Szczepanik

  3. Department of Toxicology, Jagiellonian University Medical College, Kraków, Medyczna 9, PL 30-688, Poland

    Bogusława Budziszewska

  4. Institute of Public Health, Jagiellonian University Medical College, Kraków, Grzegórzecka 20, PL 31-531, Poland

    Władysław Lasoń

  5. Maes Clinics & TRIA, Bangkok, 998 Rimklongsamsen Road, 10310, Thailand

    Michael Maes

Authors
  1. Katarzyna Curzytek
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  2. Marta Kubera
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  8. Michael Maes
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Correspondence to Marta Kubera.

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Curzytek, K., Kubera, M., Szczepanik, M. et al. Crosstalk between contact hypersensitivity reaction and antidepressant drugs. Pharmacol. Rep 65, 1673–1680 (2013). https://doi.org/10.1016/S1734-1140(13)71529-9

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  • DOI: https://doi.org/10.1016/S1734-1140(13)71529-9

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