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Preclinical studies on comorbidity between depression and psychostimulant addiction

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Abstract

Several clinical data indicate that depression is frequently comorbid with psychostimulant (cocaine, amphetamines) addiction. This short review summarizes preclinical results and observations showing how reward processes are modified in animal models of depression, and which depression-like effects are induced in experimental animals withdrawn from chronic treatment with psychostimulants.

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Authors and Affiliations

  1. Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Smętna 12, PL 31-343, Poland

    Małgorzata Filip, Małgorzata Frankowska, Joanna Jastrzębska, Karolina Wydra & Edmund Przegaliński

  2. Department of Toxicology, Faculty of Pharmacy, Jagielonian University Colege of Medicine, Kraków, Medyczna 9, PL 30-688, Poland

    Małgorzata Filip

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  1. Małgorzata Filip
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  2. Małgorzata Frankowska
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  3. Joanna Jastrzębska
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  4. Karolina Wydra
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  5. Edmund Przegaliński
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Correspondence to Edmund Przegaliński.

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Filip, M., Frankowska, M., Jastrzębska, J. et al. Preclinical studies on comorbidity between depression and psychostimulant addiction. Pharmacol. Rep 65, 1529–1534 (2013). https://doi.org/10.1016/S1734-1140(13)71514-7

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  • DOI: https://doi.org/10.1016/S1734-1140(13)71514-7

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