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The Prevalence of Serum Antineutrophil Cytoplasmic Autoantibodies in Preeclampsia and Eclampsia

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Abstract

Objectives

The purpose of this study was to evaluate the prevalence of antineutrophil cytoplasmic autoantibodies (ANCAs) in preeclampsia and eclampsia.

Methods

Blood samples were obtained from 26 mildly preeclamptic, 26 severely preeclamptic, and 20 eclamptic, and 20 normal pregnant women (controls) in the late third trimester for the determination of serum cytoplasmic pattern ANCA (cANCA) and perinuclear pattern ANCA (pANCA) by the corresponding enzyme immunoassay.

Results

Significant elevations of serum cANCA and pANCA were found in mild and severe preeclampsia and eclampsia. The extent of rise correlated well with the severity of the disease. Both ANC As were detected in 80% of eclamptic cases versus 38.5 and 69.3% of mild and severe preeclampsia, respectively. Marked elevations of serum ANCAs were associated with poor fetal outcome.

Conclusion

ANCAs may be involved in the pathogenesis of glomerulonephritis in preeclampsia and eclampsia and their presence may be attributed to an autoimmune mechanism initiated by autoantibody-mediated activation of neutrophils.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt

    Mohamed Shaarawy PhD, FRCPath, Samira Youssef El-Mallah MD & Azza MA. El-Yamani MD

  2. Department of Obstetrics and Gynecology, Al-Azhar University, Cairo, Egypt

    Mohamed Shaarawy PhD, FRCPath, Samira Youssef El-Mallah MD & Azza MA. El-Yamani MD

Authors
  1. Mohamed Shaarawy PhD, FRCPath
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  2. Samira Youssef El-Mallah MD
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  3. Azza MA. El-Yamani MD
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Shaarawy, M., El-Mallah, S.Y. & El-Yamani, A.M. The Prevalence of Serum Antineutrophil Cytoplasmic Autoantibodies in Preeclampsia and Eclampsia. Reprod. Sci. 4, 34–39 (1997). https://doi.org/10.1016/S1071-5576(96)00040-8

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  • DOI: https://doi.org/10.1016/S1071-5576(96)00040-8

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