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Endothelin Plasma Levels in Primary Amenorrheic Adolescents Before and After Estrogen Treatment

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Abstract

Objective

We evaluated the effect of estrogen administration on endothelin (ET) secretion in primary amenorrheic (PA) adolescent girls.

Methods

Fifteen PA adolescents (ten hypergonadotropic, group A; five hypogonadotropic, group B) were treated with estrogen and progestogen tablets. A control group often healthy adolescents (group C) was included in the study. The ET 1–21, FSH, and LH plasma levels were tested bejore treatment (PrT) and immediately after the last estrogen tablet but bejore the progestogen administration (PoT).

Results

A statistically significant difference (P <.01) in ET 1–21 plasma values was found between PrT (9.66 ± 0.80 pmol/L) and PoT (7.56 ± 0.89 pmol/L) levels in group A cases. A similar reduction (P <.05) was recorded between PrT (8.06 ± 0.46 pmol/L) and PoT (5.59 ± 0.53 pmol/L) ET 1–21 plasma levels in group B cases. Endothelin 1–21 plasma PrT values were higher in both group A and B cases in comparison with controls (6.66 ± 0.44 pmol/L; P < .01, P < .1, respectively).

Conclusion

Estrogens administered to PA adolescents reduce ET 1–21 plasma levels in both hyper- and hypogonadotropism.

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Authors and Affiliations

  1. Division of Pediatric and Adolescent Gynecology, First Department of Obstetrics and Gynecology, “Alexandra” Hospital, University of Athens, 9 Kanan Str, 106 71, Athens, Greece

    George C. Creatsas MD, FACS, Ariadne B. Malamitsi-Puchner MD, Elsheikh A. Hassan MD, Emmanuel B. Economou PhD & Denis I. Aravantinos MD

Authors
  1. George C. Creatsas MD, FACS
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  2. Ariadne B. Malamitsi-Puchner MD
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  3. Elsheikh A. Hassan MD
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  4. Emmanuel B. Economou PhD
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  5. Denis I. Aravantinos MD
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Creatsas, G.C., Malamitsi-Puchner, A.B., Hassan, E.A. et al. Endothelin Plasma Levels in Primary Amenorrheic Adolescents Before and After Estrogen Treatment. Reprod. Sci. 3, 350–353 (1996). https://doi.org/10.1016/S1071-5576(96)00034-2

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  • DOI: https://doi.org/10.1016/S1071-5576(96)00034-2

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