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Strategic targeting of atherosclerotic lesions

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References

  1. Thom TJ, Kannel WB, Silberschatz H, D'Agastino RB. Incidence, prevalence and mortality of cardiovascular disease in the United States. In: Alexander RW, Schlant RC, Fuster V, eds. Hurst's the heart. 9th ed. New York: Mc Graw-Hill; 1998:6.

    Google Scholar 

  2. Levy DL, Wilson PWF. Atherosclerotic cardiovascular disease: an epidemiological perspective. In: Topol EJ, ed. Textbook of cardiovascular medicine. Philadelphia: Lippincott-Raven; 1998:13–30.

    Google Scholar 

  3. Pepine CJ. Coronary angiography and cardiac catheterization. In: Topol EJ, ed. Textbook of cardiovascular medicine. Philadelphia: Lippincott-Raven; 1998:1935–56.

    Google Scholar 

  4. Mizuno K, Satomura K, Miyamoto A, Arakawa K, Shibuya T, Arai T, et al. Angioscopic evaluation of coronary-artery thrombi in acute coronary syndromes. N Engl J Med 1992;326:287–91

    PubMed  CAS  Google Scholar 

  5. Waller BF, Pinkerton CA, Stack JD. Intravascular ultrasound: a histologic study of vessels during life: the new gold standard for vascular imaging. Circulation 1992;85:2305–9.

    PubMed  CAS  Google Scholar 

  6. Hodgson JM, Reddy KG, Suneja R, Nair RN, Lesnefsky EJ, Sheehan HM. Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty. J Am Coll Cardiol 1993;21:35–44.

    PubMed  CAS  Google Scholar 

  7. Tearney GJ, Brezinski ME, Bouma BE, Boppart SA, Pitris C, Southern JF, et al. In vivo endoscopic optical biopsy with optical coherence tomography. Science 1997;276:2037–9.

    Article  PubMed  CAS  Google Scholar 

  8. Strauss HW, Fischman AJ, Kurata C, Narula J, Khaw BA. Radionuclide approaches to imaging atherosclerosis. In: Zaret BL, Kaufman L, Berson AS, Dunn RA, eds. Frontiers in noninvasive imaging. New York: Raven Press; 1993:289.

    Google Scholar 

  9. Khaw BA, Carrio I, Narula J. Targeting atherosclerotic lesions with monoclonal antibodies. In: Hollinger MA, Torchilin VP, eds. Handbook of targeted delivery of imaging agents. Boca Raton: CRC Press; 1995:429–45.

    Google Scholar 

  10. Khaw BA, Carrio I, Pieri P, Narula J. Radionuclide imaging of the synthetic smooth muscle cell phenotype in experimental atherosclerotic lesions. Trends Cardiovasc Dis 1996;6:226–32.

    Article  Google Scholar 

  11. Ross R. The pathogenesis of atherosclerosis—an update. N Eng J Med 1986;314:488–500.

    CAS  Google Scholar 

  12. Hathaway DR, March KL. Molecular cardiology: new avenues for the diagnosis and treatment of cardiovascular disease. J Am Coll Cardiol 1989;13:265–82.

    PubMed  CAS  Google Scholar 

  13. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of cornary artery disease. N Engl J Med 1991;326:242–50, 310–8.

    Google Scholar 

  14. Davies MJ, Woolfe N. Atherosclerosis: what is it and why does it occur? Br Heart J 1993;69:S3-S11.

    Article  PubMed  CAS  Google Scholar 

  15. Narula J, Ditlow C, Chen FW, Khaw BA. Monoclonal antibodies for the detection of atherosclerotic lesions. In: Monoclonal antibodies in cardiovascular diseases. Khaw BA, Narula J, Strauss HW, eds. Philadelphia: Lea & Febiger; 1994:206.

    Google Scholar 

  16. Burke AP, Farb A, Malcom GT, Liang YH, Smialek J, Virmani R. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med 1997;17:1859–67.

    Google Scholar 

  17. Farb A, Burke AP, Tang AL, Liang Y, Mannan P, Smialek J, et al. Coronary plaque erosion without rupture into a lipid core: a frequent cause of coronary thrombosis in sudden coronary death. Circulation 1996;93:1354–63.

    PubMed  CAS  Google Scholar 

  18. Lee RT, Libby P. The unstable atheroma. Arterioscler Thromb Vasc Biol 1997;17:1859–67.

    PubMed  CAS  Google Scholar 

  19. Holmes DR Jr, Vietstra RE, Smith HC, Vetrovec GW, Kent KM, Cowley MJ, et al. Restenosis after percutaneous transluminal coronary angioplasty (PTCA): a report from PTCA registry of the National Heart, Lung, and Blood Institute. Am J Cardiol 1984;53:77C-81C.

    Article  PubMed  Google Scholar 

  20. Farb A, Virmani R, Atkinson JB, Kolodgie FD. Plaque morphology and pathologic outcome after coronary balloon angioplasty. J Am Coll Cardiol 1990;16:1421–9.

    Article  PubMed  CAS  Google Scholar 

  21. Farb A, Sangiorgi G, Carter AJ, Walley VM, Edwards WD, Schwartz RS, et al. Pathology of acute and chronic coronary stenting in humans. Circulation (in press).

  22. Thyberg J, Heidin U, Sjolund M, Palmberg L, Bottger BA. Regulation of differentiated properties and proliferation of arterial smoth muscle cells. Arteriosclerosis 1990;10:966–90.

    PubMed  CAS  Google Scholar 

  23. Narula N, Haider N, Narula J. Cell biology for the nuclear cardiologist. J Nucl Cardiol 1998;5:426–37.

    Article  PubMed  CAS  Google Scholar 

  24. Dinkelborg LM, Duda SH, Hanke H, Tepe G, Hilger CS, Semmler W. Molecular imaging of atherosclerosis using a technetium-99m-labeled endothelin derivative. J Nucl Med 1998;39:1819–22.

    PubMed  CAS  Google Scholar 

  25. Pintor J, Miras-Portugal MT. Diadenosine polyphosphates (APXA) as new neurotransmitters. Drug Dev Res 1993;28:259–62.

    Article  CAS  Google Scholar 

  26. Erlinge D, You J, Wahlestedt C, Edvinsson L. Diadenosine polyphosphates as new neurotransmitters. Eur J Pharmacol 1995;289:135–49.

    Article  PubMed  CAS  Google Scholar 

  27. Elmaleh D, Narula J, Petrov A, Babich J, Fischman AJ, Khaw BA. Tc-99m-Ap4A for early gamma scintigraphic visualization of experimental atherosclerotic lesions. Proc Natl Acad Sci 1998;95:691–5.

    Article  PubMed  CAS  Google Scholar 

  28. Dewanjee MK, Narula J. Antisense mechanism for the diagnosis and treatment of cardiovascular diseases. J Nucl Cardiol (in press).

  29. Gunn J, Holt CM, Francis SE, Shepherd L, Grohmann M, Newman CM, et al. The effect of oligonucleotides to c-myb on vascular smooth muscle cell proliferation and neointima formation after porcine coronary angioplasty. Circ Res 1997;80:520–31.

    PubMed  CAS  Google Scholar 

  30. Tanner FC, Yang ZY, Duckers E, Gordon D, Nabel GJ, Nabel EG. Expression of cyclin-dependent kinase inhibitors in vascular disease. Circ Res 1998;82:396–403.

    PubMed  CAS  Google Scholar 

  31. Dewanjee MK, Ghafouripour AK, Kapadvanjwala M, Dewanjee S, Serafini AN, Lopez DM, et al. Noninvasive imaging of c-myc oncogene messenger RNA with indium-111-antisense probes in a mammary tumor-bearing mouse model. J Nucl Med 1994;35:1054–63.

    PubMed  CAS  Google Scholar 

  32. Narula J, Bianchi C, Petrov A, Ditlow C, Lister BC, Dilley J, et al. Noninvasive localization of experimental atherosclerotic lesions with mouse/human chimeric Z2D3 antibody specific for the proliferating smooth muscle cells of human atheroma. Circulation 1995;92:474–84.

    PubMed  CAS  Google Scholar 

  33. Narula J, Petrov A, Ditlow C, Pak KY, Chen FW, Khaw BA. Technetium-99m-based imaging of experimental atherosclerotic lesions by selective localization of proliferating smooth muscle cells of atheroma. Chest 1997;111:1684–90.

    Article  PubMed  CAS  Google Scholar 

  34. Narula J, Petrov A, O'Donnell SM, Ditlow C, Pieslak I, Dilley J, et al. Gamma imaging of atherosclerotic lesions: the role of antibody affinity in the in vivo target localization. J Nucl Cardiol 1996;3:231–41.

    Article  PubMed  CAS  Google Scholar 

  35. Narula J, Petrov A, Ditlow C, Pak KY, Chen FW, Khaw BA. Maximizing radiotracer delivery for scintigraphic localization of experimental atherosclerotic lesions with high-dose negative-charge-modified Z2D3 antibody. J Nucl Cardiol;1997;4:226–33.

    Article  PubMed  CAS  Google Scholar 

  36. Carrio I, Pieri P, Narula J, et al. Noninvasive localization of human atherosclerotic lesions with indium-111-labeled monoclonal Z2D3 antibody specific for proliferating smooth muscle cells. J Nucl Cardiol 1998;5:551–7.

    Article  PubMed  CAS  Google Scholar 

  37. Narula J, Kolodgie FD, Virmani R, Petrov A, Khaw BA. Should assessment of the rate of smooth muscle cell proliferation by indium-111-Z2D3 antibody imaging allow for predicting postangioplastic restenosis? [abstract]. J Nucl Med 1997;38:3.

    Google Scholar 

  38. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991;67:1033–6.

    Article  PubMed  CAS  Google Scholar 

  39. Virgolini I, Muller C, Fitscha P, Chiba P, Sinzinger H. Radiolabeling autologous monocytes with 111In oxine for reinjection in patients with atherosclerosis. Prog Clin Biol Res 1990;355:271–80.

    PubMed  CAS  Google Scholar 

  40. Steinberg D, Witzum JL. Lipoproteins, lipoprotein oxidation, and atherogenesis. In: Chien KR, ed. Molecular basis of cardiovascular disease. Philadelphia: WB Saunders Co; 1998:458–76.

    Google Scholar 

  41. Fischman AJ, Rubin RH, Delvecchio A, Strauss HW. Imaging of atheromatous lesions in the illiac and femoral vessels: preliminary experience with 111In IgG in human subjects [abstract]. J Nucl Med 1989;30:817.

    Google Scholar 

  42. Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest 1991;88:1785–92.

    Article  PubMed  CAS  Google Scholar 

  43. Lees RS, Lees AM, Strauss HW. External imaging of human atherosclerosis. J Nucl Med 1983;24:154–6.

    PubMed  CAS  Google Scholar 

  44. Lees AM, Lees RS, Schoen FJ, Issachsohn JL, Fischman AJ, McKusick KA, et al. Imaging human atherosclerosis with 99mTc-labeled LDL. Atherosclerosis 1988;8:461–70.

    CAS  Google Scholar 

  45. Ginsberg HN, Goldsmith SJ, Vallabhajosula S. Noninvasive imaging of 99mTc-labeled LDL uptake bytendon xanthomas in hypercholesterolemic patients. Arteriosclerosis 1990;10:256–62.

    PubMed  CAS  Google Scholar 

  46. DeForge LE, Schwendner SW, DeGalan MR, McConnell DS, Counsell RE. Noninvasive assessment of lipid disposition in treated and untreated atherosclerotic rabbits. Pharm Res 1989;6:1011–6

    Article  PubMed  CAS  Google Scholar 

  47. Hardoff R, Braegelmann F, Zanzonico P, Herrold EM, Lees RS, Lees AM, et al. External imaging of atherosclerosis in rabbits using an 123I-labeled synthetic peptide fragment. J Clin Pharmacol 1993;33:1039–47.

    PubMed  CAS  Google Scholar 

  48. Tsimiakis S, Palinski W, Halpern SE, Yeung DW, Curtiss LK, Witztum JL. Radiolabeled MDA 2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo. J Nucl Cardiol 1999;6:41–53.

    Article  Google Scholar 

  49. Khaw BA, Strauss HW, Narula J. “Magic bullets”: from muskets to smart bombs! J Nucl Med 1993;34:2264–8.

    PubMed  CAS  Google Scholar 

  50. Stary HC, Chandler B, Dinsmore RE, Fuster V, Glagov S, Insull W, et al. A definition of advanced types of atherosclerotic lesions and a histologic classification of atherosclerosis—a report from the committee on vascular lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1995;92:1335–74.

    Google Scholar 

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Narula, J., Virmani, R. & Iskandrian, A.E. Strategic targeting of atherosclerotic lesions. J Nucl Cardiol 6, 81–90 (1999). https://doi.org/10.1016/S1071-3581(99)90068-5

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