Skip to main content
Log in

Are the differences between adenosine and dipyridamole clinically relevant?

  • Editorials
  • Published:
Journal of Nuclear Cardiology Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Iskandrian AS, Verani MS, Heo J. Pharmacologic stress testing: mechanism of action, hemodynamic responses and results in detection of coronary artery disease. J Nucl Cardiol 1994;1:94–111.

    Article  PubMed  CAS  Google Scholar 

  2. Ranhosky A, Kempthorne-Rawson J, Intravenous Dipyridamole Thallium Imaging Study Group. The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Circulation 1990;81:1205–9.

    PubMed  CAS  Google Scholar 

  3. Iskandrian AS, Heo J, Askenase A, Segal BL, Auerbach N. Dipyridamole cardiac imaging. Am Heart J 1988;115:432–43.

    Article  PubMed  CAS  Google Scholar 

  4. Bellardinelli L, Linden J, Berne R. The cardiac effects of adenosine. Prog Cardiovasc Dis 1989;32:73–97.

    Article  Google Scholar 

  5. Verani MS, Mahmarian JS, Hixson JB, Boyce TM, Staudacher RA. Diagnosis of coronary artery disease by controlled coronary vasodilation with adenosine and thallium-201 scintigraphy in patients unable to exercise. Circulation 1990;82:80–7.

    PubMed  CAS  Google Scholar 

  6. Ogilby D, Iskandrian AS, Untereker W, Heo J, Nguyen TN, Mercuro J. Effect of intravenous adenosine infusions on myocardial perfusion and function: hemodynamic angiographic and scintigraphic study. Circulation 1992;86:887–95.

    PubMed  CAS  Google Scholar 

  7. Cerqueira MD, Verani MS, Schwaiger M, Heo J, Iskandrian AS. Safety profile of adenosine stress perfusion imaging in 9,256: results from the Adenoscan Multicenter Trial Registry. J Am Coll Cardiol 1994;23:384–9.

    PubMed  CAS  Google Scholar 

  8. Miyagawa M, Kumano S, Sekiya M, et al. Thallium-201 myocardial tomography with intravenous infusion of adenosine triphosphate in diagnosis of coronary artery disease. J Am Coll Cardiol 1995;26:1196–201.

    Article  PubMed  CAS  Google Scholar 

  9. Glover DK, Ruiz M, Koplan BA, et al. WRC-470 (2-cyclohexylmethylhydrainoadenosine): a new selective adenosine α2a receptor agonist with potential for pharmacologic stress imaging [Abstract]. J Am Coll Cardiol 1994;23:127A.

    Google Scholar 

  10. McLaughlin DP, Beller GA, Linden J, et al. Hemodynamic and metabolic correlates of dipyridamole-induced myocardial thallium-201 perfusion abnormalities in multivessel coronary artery disease. Am J Cardiol 1994;74:1159–64.

    Article  Google Scholar 

  11. Nussbacher A, Arie S, Kalil R, et al. Mechanism of adenosine-induced elevation of pulmonary capillary wedge pressure in humans. Circulation 1995;92:371–9.

    PubMed  CAS  Google Scholar 

  12. Haywood G, Sneddon J, Bashir Y, Jennison S, Gray H, McKenna W. Adenosine infusion for the reversal of pulmonary vasoconstriction in biventricular failure, a good test but a poor therapy. Circulation 1992;86:986–92.

    Google Scholar 

  13. Ure NG, Camici PG, Melin JA, et al. Effect of aging on myocardial perfusion reserve. J Nucl Med 1995;36:2036.

    Google Scholar 

  14. Böttcher M, Czernin J, Sun KT, et al. Effect of caffeine on myocardial blood flow at rest and during pharmacologic vasodilation. J Nucl Med 1995;36:216–21.

    Google Scholar 

  15. Sambuceti G, Murzullo P, Giorgetti A, et al. Global alteration in perfusion response to increasing oxygen consumption in patients with single-vessel coronary artery disease. Circulation 1994;90: 1696–702.

    PubMed  CAS  Google Scholar 

  16. Rossen JD, Simonetti I, Marans ML, Winniford MD, Coronary dilation with standard dose dipyridamole and dipyridamole combined with hand-grip. Circulation 1989;79:556–72.

    Google Scholar 

  17. Rossen JD, Quillen JE, Lopez JAG, Stenberg RG, Talman CL, Winniford MD. Comparison of coronary vasodilation with intravenous dipyridamole and adenosine. J Am Coll Cardiol 1991;18: 485–91.

    Article  PubMed  CAS  Google Scholar 

  18. Czernin J, Müller P, Chan S, et al. Influence of age and hemodynamics on myocardial blood flow and flow reserve. Circulation 1993;88:62–9.

    PubMed  CAS  Google Scholar 

  19. Gould KL, Lipscomb K, Hamilton GW. Physiologic basis for assessing critical coronary stenosis. Am J Cardiol 1974;33:87–94.

    Article  PubMed  CAS  Google Scholar 

  20. Uren NG, Melin JA, De Bruyne B, Wijns W, Baudhuin T, Camici PG. Relation between myocardial blood flow and severity of coronary-artery stenosis. N Engl J Med 1994;330:1782–7.

    Article  PubMed  CAS  Google Scholar 

  21. Wilson RF, Wychek, Christensen BV, et al. Effects of adenosine on human coronary arterial circulation. Circulation 1990;82:1595–606.

    PubMed  CAS  Google Scholar 

  22. Quyyumi AA, Dakak N, Andrews NP, et al. Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation 1995;92:320–6.

    PubMed  CAS  Google Scholar 

  23. Lee J, Chae SC, Lee K, Heo J, Iskandrian AS. Biokinetics of thallium-201 in normal subjects: comparison between adenosine, dipyridamole, dobutamine and exercise. J Nucl Med 1994;35:535–41.

    PubMed  CAS  Google Scholar 

  24. Santose-Ocampo CD, Herman SD, Travin MI, et al. Comparison of exercise, dipyridamole and adenosine by use of technetium 99m sestamibi tomographic imaging. J Nucl Cardiol 1994;1:57–64.

    Article  Google Scholar 

  25. Taillefer R, Amyot R, Turpin S, et al. Comparison between dipyridamole and adenosine as pharmacologic coronary vasodilators in detection of coronary artery disease with thallium-201 imaging. J Nucl Cardiol (in press).

Download references

Author information

Authors and Affiliations

Authors

Additional information

Supported in part by the Sidney Kimmel Cardiovascular Research Center

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iskandrian, A.S. Are the differences between adenosine and dipyridamole clinically relevant?. J Nucl Cardiol 3, 281–283 (1996). https://doi.org/10.1016/S1071-3581(96)90042-2

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1016/S1071-3581(96)90042-2

Navigation