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Independent and incremental prognostic value of exercise thallium single-photon emission computed tomographic imaging in women

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

This study examined the independent and incremental prognostic value of exercise thallium single-photon emission computed tomographic imaging in 212 women who also underwent coronary angiography.

Methods and Results

The left ventricular ejection fraction was normal (65%±15%). During a mean follow-up of 40 months, 27 women had events (cardiac death or nonfatal myocardial infarction). Univariate Cox survival analysis showed several variables to be different between patients with events and those without events: age, exercise heart rate, the extent of coronary artery disease, reversible thallium defects, number of segments with reversible abnormality, and size of perfusion abnormality. Multivariate survival analysis showed that a large perfusion abnormality and age were the independent predictors of events. Actuarial life-table analysis showed that women with a large thallium abnormality (≥15% of the myocardium) had significantly worse event-free survival rates than had women with no or small abnormalities (Mantel-Cox statistic=16; p=0.0001).

Conclusions

Thus exercise thallium-201 single-photon emission computed tomographic imaging provides independent and incremental prognostic information to clinical, exercise, and coronary angiographic results in women. The presence of a larger thallium abnormality identifies women at high risk of cardiac events.

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Authors and Affiliations

  1. Presbyterian Medical Center, Philadelphia Heart Institute, 51 N. 39th St., 19104, Philadelphia, PA

    Samir B. Pancholy, Alia Abdel Fattah, Abdalla M. Kamal, Massroor Ghods, Jaekyeong Heo & Abdulmassih S. Iskandrian

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  1. Samir B. Pancholy
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  2. Alia Abdel Fattah
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  3. Abdalla M. Kamal
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  4. Massroor Ghods
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  5. Jaekyeong Heo
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  6. Abdulmassih S. Iskandrian
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Pancholy, S.B., Fattah, A.A., Kamal, A.M. et al. Independent and incremental prognostic value of exercise thallium single-photon emission computed tomographic imaging in women. J Nucl Cardiol 2, 110–116 (1995). https://doi.org/10.1016/S1071-3581(95)80021-2

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  • DOI: https://doi.org/10.1016/S1071-3581(95)80021-2

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