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Exercise training improves insulin-stimulated myocardial glucose uptake in patients with dilated cardiomyopathy

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

The effects of exercise training on myocardial substrate utilization have not previously been studied in patients with idiopathic dilated cardiomyopathy and mild heart failure.>/<

Methods and Results

Myocardial glucose uptake was studied in 15 clinically stable patients with dilated cardiomyopathy (New York Heart Association class I-II, ejection fraction 34% ± 8%) with the use of 2-[fluorine 18]fluoro-2-deoxy-D-glucose ([F-18]FDG) and positron emission tomography under euglycemic hyperinsulinemia. Eight of these patients participated in a 5-month endurance and strength training program, whereas seven patients served as nontrained subjects. Left ventricular function was assessed by 2-dimensional echocardiography before and after the intervention. After the training period, insulin-stimulated myocardial fractional [F-18]FDG uptake and glucose uptake rates were significantly increased in the anterior, lateral, and septal walls (P > .01) in the trained subjects but remained unchanged in the nontrained subjects. In the trained patients, whole-body insulin-stimulated glucose uptake was enhanced and serum free fatty acid levels were suppressed during hyperinsulinemia compared with the baseline study (P > .05). No changes were observed in the nontrained group.>/<

Conclusions

These results indicate that exercise training in patients with dilated cardiomyopathy improves insulin-stimulated myocardial glucose uptake. This improvement in glucose uptake may be indicative of a switch in myocardial preference to a more energy-efficient substrate. >/<

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Author information

Authors and Affiliations

  1. The Turku PET Centre, University of Turku and Turku University Central Hospital, PO Box 52, FIN-20521, Turku, Finland

    Kira Q. Stolen, Jukka Kemppainen, Kari K. Kalliokoski, Tapio Viljanen, Pirjo Nuutila & Juhani Knuuti

  2. The Department of Clinical Physiology, University of Turku and Turku University Central Hospital, Turku, Finland

    Matti Luotolahti

  3. The Department Medicine, University of Turku and Turku University Central Hospital, Turku, Finland

    Pirjo Nuutila

Authors
  1. Kira Q. Stolen
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  2. Jukka Kemppainen
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  3. Kari K. Kalliokoski
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  4. Matti Luotolahti
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  5. Tapio Viljanen
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  6. Pirjo Nuutila
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  7. Juhani Knuuti
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Corresponding author

Correspondence to Juhani Knuuti.

Additional information

This study was supported in part by the Ministry of Education, the Aarne Koskelo Foundation, the Research Foundation of Orion Corporation, and the Finnish Cardiovascular Foundation.

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Stolen, K.Q., Kemppainen, J., Kalliokoski, K.K. et al. Exercise training improves insulin-stimulated myocardial glucose uptake in patients with dilated cardiomyopathy. J Nucl Cardiol 10, 447–455 (2003). https://doi.org/10.1016/S1071-3581(03)00528-2

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  • DOI: https://doi.org/10.1016/S1071-3581(03)00528-2

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