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Experimental validation of a new coronary guide wire labeled with rubidium 81/krypton 81m for continuous assessment of myocardial blood flow

  • Original Articles
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

The rubidium 81/krypton 81m method was suggested for assessment of myocardial blood flow (MBF) three decades ago. This study investigates the novel concept of using 81Rb-/81mKr-labeled coronary guide wires with wire-attached 81Rb activity and diffusable 81mKr gas for assessment of lesion-specific impairment of MBF by evaluation of the 81Rb/81mKr activity ratio. The feasibility of wire production is tested, and application of the method is investigated in the canine model.

Methods and Results

Conventional coronary guide wires for angioplasty (0.014 in) were labeled with radioactive 81Rb/81mKr by ion bombardment of the wire tip. A total of 16 of the 18 wires labeled in series showed successful 81Rb fixation in combination with free 81mKr gas diffusability during quality control measurements. The suitability of the wires to assess MBF in combination with an external gamma ray detector was investigated in open-chested dogs. Electromagnetic measurement of coronary blood flow (CBF) was used as reference, providing a signal that is directly linked to volumetric MBF. The 81Rb/81mKr ratio tracked changes in CBF reliably in all 6 dogs. The found linear dependence of measured 81Rb/81mKr count rates on measured CBF supports the modeling assumptions made to apply the theoretic basis of the 81Rb/81mKr technique to 81Rb-labeled coronary guide wires.

Conclusion

81Rb-/81mKr-labeled coronary guide wires provide a signal that indicates volumetric MBF directly. This unique capability may qualify the technique as a valuable tool for research purposes and as an attractive method for invasive cardiology at centers where the logistic arrangements for short-lived isotope supply are provided.

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Authors and Affiliations

  1. Medical Clinic III (Department of Cardiology/Angiology), University of Saarland, Homburg/Saar, Germany

    Hans-Peter Stoll, Anja Sommer, Nicola Hellwig, Klaus Bonaventura & Hermann Schieffer

  2. Department of Thoracic and Cardiovascular Surgery, University of Saarland, Homburg/Saar, Germany

    Hanno Huwer

  3. Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany

    Brigitte Vollmar & Michael D. Menger

  4. Cyclotron Department, Research Center, Karlsruhe, Germany

    Jürgen Bialy, Markus Schmitt & Johannes W. Peters

Authors
  1. Hans-Peter Stoll
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  2. Hanno Huwer
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  3. Brigitte Vollmar
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  4. Jürgen Bialy
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  5. Markus Schmitt
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  6. Johannes W. Peters
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  7. Anja Sommer
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  8. Nicola Hellwig
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  9. Klaus Bonaventura
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  10. Michael D. Menger
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  11. Hermann Schieffer
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Stoll, HP., Huwer, H., Vollmar, B. et al. Experimental validation of a new coronary guide wire labeled with rubidium 81/krypton 81m for continuous assessment of myocardial blood flow. J Nucl Cardiol 7, 255–262 (2000). https://doi.org/10.1016/S1071-3581(00)80014-8

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  • DOI: https://doi.org/10.1016/S1071-3581(00)80014-8

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