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Regional myocardial oxygen consumption estimated by carbon-11 acetate and positron emission tomography before and after repetitive ischemia

  • Original Articles
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Preserved myocardial oxygen consumption estimated by carbon 11-acetate and positron emission tomography (PET) in myocardial regions with chronic but reversibly depressed contractile function in patients with ischemic heart disease have been suggested to be caused by repeated short episodes of acute myocardial ischemia. To evaluate this hypothesis myocardial 11C-acetate PET imaging was performed before and after acute repetitive myocardial ischemia.

Methods and Results

In open chest dogs (n=8), the left anterior descending coronary artery was occluded 4 times for 5 minutes alternating with 5 minutes of reperfusion. Before and after repetitive coronary occlusions, oxygen 15 water/oxygen 15 carbon monoxide (blood flow), and 11C-acetate (oxygen consumption) PET imaging were performed. Left ventricular regional systolic wall thickening was measured with sonomicrometry. Forty-five minutes after the ischemic episodes, systolic ventricular wall thickening was decreased by 90%, whereas myocardial blood flow was reduced by 21% compared with baseline values (P<.05). Ninety minutes after the ischemic episodes, estimated oxygen consumption was unaltered compared with the baseline level despite a sustained 70% decrease in the regional contractile function (P<.05).

Conclusions

Oxygen consumption estimated by 11C-acetate PET imaging is preserved after repeated episodes of acute myocardial ischemia despite a severe impairment of contractile function.

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Authors and Affiliations

  1. Division of Cardiology, Medical Department B, The Heart Center, Rigshospitalet, University of Copenhagen, Denmark

    Klaus F. Kofoed, Peter R. Hansen, Jens D. Hove, Jesper H. Svendsen & Henning Kelbæk

  2. Cyctotron and PET Unit, Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University of Copenhagen, Denmark

    Soren Holm, Mikael Jensen & Birger Hesse

  3. Neurobiology Research Unit, Rigshospitalet, University of Copenhagen, Denmark

    Hidehiro Iida

  4. Department of Mathematics, Arizona State University, Tempe, Arizona

    Kewei Chen

  5. Department of Mathematics, Beijing Normal University, Beijing, China

    Wen Jin

Authors
  1. Klaus F. Kofoed
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  2. Peter R. Hansen
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  3. Soren Holm
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  4. Jens D. Hove
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  5. Kewei Chen
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  6. Wen Jin
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  7. Mikael Jensen
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  8. Hidehiro Iida
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  9. Birger Hesse
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  10. Jesper H. Svendsen
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  11. Henning Kelbæk
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Corresponding author

Correspondence to Klaus F. Kofoed.

Additional information

This study was supported by the Danish Heart Foundation, the Alfred Benzon Foundation, the John and Birthe Meyer foundation, the Laerdal foundation, the Foundation of 1921, and the Foundation of 1870.

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Kofoed, K.F., Hansen, P.R., Holm, S. et al. Regional myocardial oxygen consumption estimated by carbon-11 acetate and positron emission tomography before and after repetitive ischemia. J Nucl Cardiol 7, 228–234 (2000). https://doi.org/10.1016/S1071-3581(00)70011-0

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  • DOI: https://doi.org/10.1016/S1071-3581(00)70011-0

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