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Effect of electrospray needle voltage on electroosmotic flow in capillary electrophoresis-mass spectrometry

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Journal of the American Society for Mass Spectrometry

Abstract

The effect of the electrospray ionization (ESI) needle voltage on the electroosmotic flow (EOF) in capillary electrophoresis (CE)-mass spectrometry (MS) was investigated. The radial electric field that penetrates across the CE capillary wall imposed by the ESI needle voltage modifies the typical EOF. This effect was investigated for buffers commonly used in CE-MS. Variations as high as ±30% were observed.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA

    Iulia M. Lazar & Milton L. Lee

Authors
  1. Iulia M. Lazar
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  2. Milton L. Lee
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Correspondence to Milton L. Lee.

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Lazar, I.M., Lee, M.L. Effect of electrospray needle voltage on electroosmotic flow in capillary electrophoresis-mass spectrometry. J Am Soc Mass Spectrom 10, 261–264 (1999). https://doi.org/10.1016/S1044-0305(98)00151-2

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  • DOI: https://doi.org/10.1016/S1044-0305(98)00151-2

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