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Multi-anode detection in electrospray ionization time-of-flight mass spectrometry

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Journal of the American Society for Mass Spectrometry

Abstract

An electrospray ionization ion source coupled to a time-of-flight mass analyzer incorporating a multi-anode time-to-digital converter is described. High-speed data acquisition (kHz mass spectral acquisition) rates are achieved. The four-anode detector produces a significant increase in detection/counting efficiency over that for a single-anode detector. In this work a 2. 5 times increase in detection efficiency is demonstrated. The multi-anode detector is also used as a diagnostic tool to optimize transmission of the ion optics.

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Authors and Affiliations

  1. Department of Chemistry, Texas A&M University, The Laboratory for Biological Mass Spectrometry, College Station, Texas, USA

    D. C. Barbacci & D. H. Russell

  2. IonWerks, Inc., Houston, Texas, USA

    J. A. Schultz, J. Holocek, S. Ulrich, W. Burton & M. Van Stipdonk

Authors
  1. D. C. Barbacci
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  2. D. H. Russell
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  3. J. A. Schultz
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  4. J. Holocek
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  5. S. Ulrich
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  6. W. Burton
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  7. M. Van Stipdonk
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Corresponding author

Correspondence to D. H. Russell.

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Barbacci, D.C., Russell, D.H., Schultz, J.A. et al. Multi-anode detection in electrospray ionization time-of-flight mass spectrometry. J Am Soc Mass Spectrom 9, 1328–1333 (1998). https://doi.org/10.1016/S1044-0305(98)00113-5

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  • DOI: https://doi.org/10.1016/S1044-0305(98)00113-5

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