Abstract
Externally generated ions are accumulated in a linear octopole ion trap before injection into our 9.4 T Fourier transform ion cyclotron resonance (FT-ICR) mass analyzer. Such instrumental configuration has previously been shown to provide improved sensitivity, scan rate, and duty cycle relative to accumulated trapping in the ICR cell. However, inefficient ion ejection from the octopole currently limits both detection limit and scan rate. SIMION 7.0 analysis predicts that a dc axial electric field inside the linear octopole ion trap expedites and synchronizes the efficient extraction of the octopole-accumulated ions. Further SIMION analysis optimizes the ion ejection properties of each of three electrode configurations designed to produce a near-linear axial potential gradient. More efficient extraction and transfer of accumulated ions spanning a wide m/z range promises to reduce detection limit and increase front-end sampling rate (e.g., to increase front-end resolution for separation techniques coupled with FT-ICR mass analysis). Addition of the axial field improves experimental signal-to-noise ratio by more than an order of magnitude.
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McLuckey, S. A.; Van Berkel, G. J.; Goeringer, D. E.; Glish, G. L. Ion Trap Mass Spectrometry of Externally Generated Ions. Anal. Chem. 1994, 66, 689A-696A.
March, R. E. An Introduction to Quadrupole Ion Trap Mass Spectrometry. J. Mass Spectrom. 1997, 32, 351–369.
Marshall, A. G.; Hendrickson, C. L.; Jackson, G. S. Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: A Primer. Mass Spectrom. Rev. 1998, 17, 1–35.
Hendrickson, C. L.; Emmett, M. R. Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Annu. Rev. Phys. Chem. 1999, 50, 517–536.
Senko, M. W.; Hendrickson, C. L.; Pasa-Tolic, L.; Marto, J. A.; White, F. M.; Guan, S.; Marshall, A. G. Electrospray Ionization FT-ICR Mass Spectrometry at 9.4 tesla. Rapid Commun. Mass Spectrom. 1996, 10, 1824–1828.
Senko, M. W.; Hendrickson, C. L.; Emmett, M. R.; Shi, S. D.-H.; Marshall, A. G. External Accumulation of Ions for Enhanced Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. J. Am. Soc. Mass Spectrom. 1997, 8, 970–976.
Sannes-Lowery, K.; Griffey, R. H.; Kruppa, G. H.; Speir, J. P.; Hofstadler, S. A. Multipole Sotrage Assisted Dissociation, a Novel In-Source Dissociation Technique for Electrospray Ionization Generated Ions. Rapid Commun. Mass Spectrom. 1998, 12, 1957–1961.
Bier, M. E.; Park, M.; Syka, J. E. P. Ion Trap Mass Spectrometer System and Method. U.S.A. Patent 5,420,425, issued 30 May, 1995.
Rodgers, M. T.; Campbell, S.; Marzluff, E. M.; Beauchamp, J. L. Low-Energy Collision-Induced Dissociation of Deprotonated Dinucleotides: Determination of the Energetically Favored Dissociation Pathways and the Relative Acidities of the Nucleic Acid Bases. Int. J. Mass Spectrom. Ion Processes 1994, 137, 121–149.
Voyksner, R. D.; Lee, H. Investigating the Use of an Octopole Ion Guide for Ion Storage and High-Pass Mass Filtering to Improve the Quantitative Performance of Electrospray Ion Trap Mass Spectrometry. Rapid Commun. Mass Spectrom. 1999, 13, 1427–1437.
Belov, M. E.; Nikolaev, E. N.; Anderson, G. A.; Udseth, H. R.; Conrads, T. P.; Veenstra, T. D.; Masselon, C. D.; Gorshkov, M. V.; Smith, R. D. Design and Performance of an ESI Interface for Selective External Ion Accumulation Coupled to a Fourier Transform Ion Cyclotron Mass Spectrometer. Anal. Chem. 2001, 73, 253–261.
Javahery, G.; Thompson, B. A. A Segmented Radiofrequency-Only Quadrupole Collision Cell for Measurements of Ion Collision Cross Section on a Triple Quadrupole Mass Spectrometer. J. Am. Soc. Mass Spectrom. 1997, 8, 697–702.
Thomson, B. A.; Joliffe, C. L. Spectrometer with Axial Field. U.S.A. Patent 5,847,386, issued December 8, 1998.
Thomson, B. A.; Joliffe, C.; Javahery, R. RF-Only Quadrupoles with Axial Fields. Proceedings of the 44th ASMS Conference on Mass Spectrometry and Allied Topics; Portland, OR, May 1996; Vol. I, p 1155.
Thomson, B. A.; Jolliffe, C. L. Quadrupole with Axial DC Field. U.S.A. Patent 6,111,250, issued August 29, 2000.
Tolmachev, A. V.; Udseth, H. R.; Smith, R. D. Charge Capacity Limitations of Radio Frequency Ion Guides in their Use for Improved Ion Accumulation and Trapping in Mass Spectrometry. Anal. Chem. 2000, 72, 970–978.
Dodonov, A.; Kozlovsky, V.; Loboda, A.; Raznikov, V.; Sulimendov, I.; Tolmachev, A.; Kraft, A.; Wollnik, H. A New Technique for Decomposition of Selected Ions in Molecule Ion Reactor Coupled with Ortho-Time-of-Flight Mass Spectrometry. Rapid Commun. Mass Spectrom. 1997, 11, 1649–1656.
Mansoori, B. A.; Dyer, E. W.; Lock, C. M.; Bateman, K.; Boyd, R. K.; Thompson, B. A. Analytical Performance of a High-Pressure Radio Frequency-Only Quadrupole Collision Cell with an Axial Field Applied by Using Conical Rods. J. Am. Soc. Mass Spectrom. 1998, 9, 775–788.
Gerlich, D. Inhomogeneous RF Fields: A Versatile Tool for the Study of Processes with Slow Ions. State-Selected and State-to-State Ion-Molecule Reaction Dynamics. Part 1. Experiment; Ng, C. Y.; Baer, M., Eds; John Wiley and Sons Inc.: New York, 1992; Vol. LXXXII, pp 1–176.
Loboda, A.; Drutchnsky, A.; Loboda, O.; McNabb, J.; Spicer, V.; Ens, W.; Standing, K. Novel LINAC II Electrode Geometry to Create an Axial Field in a Multipole Ion Guide. Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics; Long Beach, CA, June 2000; WPA016.
Loboda, A.; Krutchinsky, A.; Loboda, O.; McNabb, J.; Spicer, V.; Ens, W.; Standing, K. Novel Linac II Electrode Geometry for Creating an Axial Field in a Multipole Ion Guide. Euro. J. Mass Spectrom. 2000, 6, 531–536.
March, R. E.; Hughes, R. J. Quadrupole Storage Mass Spectrometry. Wiley: New York, 1989.
Dawson, P. H. Quadrupole Mass Spectrometry and its Application. Elsevier: Amsterdam, 1976.
Hagg, C.; Szabo, I. New Ion-Optical Devices Utilizing Oscillatory Electric Fields. III. Stability of Ion Motion in a Two-Dimensional Octopole Field. Int. J. Mass Spectrom. Ion Processes 1986, 73, 277–294.
Hagg, C.; Szabo, I. New Ion-Optical Devices Utilizing Oscillatory Electric Fields. IV. Computer Simulations of the Transport of an Ion Beam through an Ideal Quadrupole, Hexapole, and Octopole Operating in the RF-Only Mode. Int. J. Mass Spectrom. Ion Processes 1986, 73, 295–312.
Wang, Y.; Shi, S. D.-H.; Hendrickson, C. L.; Marshall, A. G. Mass-Selective Ion Accumulation and Fragmentation in a Linear Octopole Ion Trap External to a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer. Int. J. Mass Spectrom. 2000, 198, 113–120.
Rama Rao, V. V. K.; Bhutani, A. Electric Hexapoles and Octopoles with Optimized Circular Section Rods. Int. J. Mass Spectrom. 2000, 202, 31–36.
Lock, C. M.; Dyer, E. W. Characterization of High Pressure Quadrupole Collision Cells Possessing Direct Current Axial Fields. Rapid Commun. Mass Spectrom. 1999, 13, 432–448.
Alford, J. M.; Williams, P. E.; Trevor, D. J.; Smalley, R. E. Metal Cluster ICR. Combining Supersonic Metal Cluster Beam Technology with FT-ICR. Int. J. Mass Spectrom. Ion Processes 1986, 72, 33–51.
Emmett, M. R.; White, F. M.; Hendrickson, C. L.; Shi, S. D.-H.; Marshall, A. G. Application of Micro-Electrospray Liquid Chromatography Techniques to FT-ICR MS to Enable High Sensitivity Biological Analysis. J. Am. Soc. Mass Spectrom. 1998, 9, 333–340.
Quenzer, T. L.; Emmett, M. R.; Hendrickson, C. L.; Kelly, P. H.; Marshall, A. G. High Sensitivity Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Biological Analysis with Nano-LC and Microelectrospray Ionization. Anal. Chem. 2001, 73, 1721–1725.
Senko, M. W.; Canterbury, J. D.; Guan, S.; Marshall, A. G. A High-Performance Modular Data System for FT-ICR Mass Spectrometry. Rapid Commun. Mass Spectrom. 1996, 10, 1839–1844.
Blakney, G. T.; van der Rest, G.; Johnson, J. R.; Freitas, M. A.; Drader, J. J.; Shi, S. D.-H.; Hendrickson, C. L.; Kelleher, N. L.; Marshall, A. G. Further Improvements to the MIDAS Data Station for FT-ICR Mass Spectrometry. Proceedings of the 49th ASMS Conference on Mass Spectrometry and Allied Topics; Chicago, IL, May 2001; WPM265.
Davidson, R. C. Physics of Nonneutral Plasmas. Addison-Wesley: Reading, MA, 1990.
Beu, S. C.; Hendrickson, C. L.; Vartanian, V. H.; Laude, D. A., Jr. Debye Shielding Mechanism for Trapping Ions Formed by Laser Desorption FT/ICR/MS. Int. J. Mass Spectrom. Ion Processes 1992, 113, 59–79.
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Wilcox, B.E., Hendrickson, C.L. & Marshall, A.G. Improved ion extraction from a linear octopole ion trap: SIMION analysis and experimental demonstration. J. Am. Soc. Spectrom. 13, 1304–1312 (2002). https://doi.org/10.1016/S1044-0305(02)00622-0
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DOI: https://doi.org/10.1016/S1044-0305(02)00622-0