Abstract
Non-covalent inclusion complexes formed between amino acids and derivatized calix[6]arenes are observed in MALDI mass spectrometry. The methyl, ethyl, and propyl ester derivatives of calix[6]arene yielded amino acid complexes, while the smaller calix[4]arene analogs did not. Similarly the underivatized calix[6]arene and calix[4]arene did not produce complexes. Amino acid complexes were observed for nearly all 20 amino acids in time-of-flight (TOF) analysis. In Fourier transform mass spectrometry (FTMS) analysis, however, only the most basic amino acids arginine, histidine, and lysine formed stable adducts. The complexes were abundant under matrix-assisted laser desorption ionization (MALDI) conditions, which suggested favorable interactions between host and guest.
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Stone, M.M., Franz, A.H. & Lebrilla, C.B. Non-covalent calixarene-amino acid complexes formed by MALDI-MS. J Am Soc Spectrom 13, 964–974 (2002). https://doi.org/10.1016/S1044-0305(02)00417-8
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DOI: https://doi.org/10.1016/S1044-0305(02)00417-8