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Controlled ion fragmentation in a 2-D quadrupole ion trap for external ion accumulation in ESI FTICR mass spectrometry

  • Short Communication
  • Published:
Journal of the American Society for Mass Spectrometry

Abstract

Undesired fragmentation of electrospray generated ions in an rf multipole traps can be problematic in many applications. Of special interest here is ion dissociation in a 2-D quadrupole ion trap external to a Fourier transform ion cyclotron resonance mass spectrometer (FTICR MS) used in proteomic studies. In this work, we identified the experimental parameters that determine the efficiency of ion fragmentation. We have found that under the pressure conditions used in this study there is a specific combination of the radial and axial potential well depths that determines the fragmentation threshold. This combination of rf and dc fields appears to be universal for ions of different mass-to-charge ratios, molecular weights, and charge states. Such universality allows the fragmentation efficiency of the trapped ions in the course of capillary liquid chromatography (LC) separation studied to be controlled and can increase the useful duty cycle and dynamic range of a FTICR mass spectrometer equipped with an external rf only 2-D quadrupole ion trap.

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Authors and Affiliations

  1. Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, MS K8-98, P. O. Box 999, 99352, Richland, WA, USA

    Mikhail E. Belov, Michael V. Gorshkov, Harold R. Udseth & Richard D. Smith

  2. Institute of Energy Problems of Chemical Physics, Russian Academy of Sciences, 117829, Moscow, Russia

    Michael V. Gorshkov

Authors
  1. Mikhail E. Belov
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  2. Michael V. Gorshkov
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  3. Harold R. Udseth
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  4. Richard D. Smith
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Correspondence to Richard D. Smith.

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Belov, M.E., Gorshkov, M.V., Udseth, H.R. et al. Controlled ion fragmentation in a 2-D quadrupole ion trap for external ion accumulation in ESI FTICR mass spectrometry. J Am Soc Mass Spectrom 12, 1312–1319 (2001). https://doi.org/10.1016/S1044-0305(01)00318-X

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  • DOI: https://doi.org/10.1016/S1044-0305(01)00318-X

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