Abstract
We studied by tandem mass spectrometry two isomers of nitro meso-tetraphenylporphyrin, one with a nitro group in the para position of a phenyl ring and the other with the same group in a β-pyrrolic position, and their copper complexes. Collisional activation of the molecular ions of both free-base porphyrins and of their copper complexes produces an array of product ions that permit ready differentiation of the two positional isomers. The diagnostic ions, when the nitro group is in a β-pyrrolic position, may be produced through intramolecular and double cyclization processes, triggered by the interaction of the nitro substituent with the neighboring meso-phenyl ring. These diagnostic ions do not form when the nitro group is in the para position. The gas-phase processes have precedents in solution chemistry.
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References
Wasielewski, M. R. Chem. Rev. 1992, 92, 435–461.
Metalloporphyrins in Catalytic Oxidations; Sheldon, R. A., Ed; Dekker: New York, 1994.
The Colours of Life—An Introduction to the Chemistry of Porphyrins and Related Compounds; Milgrom, L. R., Ed; Oxford University Press: Oxford, 1997, pp 216–230.
Hombrecher, H. K.; Gherdan, V. M.; Ohm, S.; Cavaleiro, J. A. S.; Neves, M. G. P. M. S.; Condesso, M. F. Tetrahedron 1993, 49, 8569–8577.
Medforth, C. J.; Berber, M. D.; Smith, K. M. Tetrahedron Lett. 1990, 31, 3719.
Barkigia, K. M.; Berber, M. D.; Fajer, J. C.; Medforth, J.; Renner, M. W.; Smith, K. M. J. Am. Chem. Soc. 1990, 112, 8851–8857.
Lüdtke, K.; Alonso, C. M. A.; Neves, M. G. P. M. S.; Silva, A. M. S.; Cavaleiro, J. A. S.; Hombrecher, H. K. Heterocyclic Commun. 1997, 3, 503–506.
Kruper, W. J., Jr.; Chamberlin, T. A.; Kochanny, M. J. Org. Chem. 1989, 54, 2753–2756.
Baldwin, J. E.; Crossley, M. J.; DeBernardis, J. Tetrahedron 1982, 38, 685–692.
Giraudeau, A.; Callot, H. J.; Jordan, J.; Ezhar, I.; Gross, M. J. Am. Chem. Soc. 1979, 101, 3857–3862.
Gross, M. L. In Methods in Enzymology, Vol. 193, Mass Spectrometry; McCloskey, J. A., Ed.; Academic: San Diego, 1990; pp 131–153.
Van Berkel, G. J.; McLuckey, S. A.; Glish, G. L. Anal. Chem. 1991, 63, 1098–1109.
Van Berkel, G. J.; McLuckey, S. A.; Glish, G. L. Anal. Chem. 1992, 64, 1586–11593.
Crombie, R. A.; Harrison, A. G. Org. Mass Spectrom. 1988, 23, 327–333.
Interpretation of Mass Spectra; McLafferty, F. W.; Turecek, F., Ed; University Science Books: Mill Valley, 1993; pp 278–279.
Rubino, F. M.; Mascaro, P.; Banfi, S.; Quici, S. Org. Mass Spectrom. 1991, 26, 161–166.
Quirke, J. M. E. In The Porphyrin Handbook, Vol. 7, Theoretical and Physical Characterization; Kadish, K. M.; Smith, K. M.; Guilard, R., Ed.; Academic: San Diego, 2000; pp 371–422.
Callot, H. J.; Schaeffer, E.; Cromer, R.; Metz, F. Tetrahedron 1990, 15, 5253–5262.
Barloy, L.; Dolphin, D.; Dupré, D.; Wijesekera, T. P. J. Org. Chem. 1994, 59, 7976–7985.
Faustino, M. A.; Neves, M. G. P. M. S.; Vicente, M. G. H.; Silva, A. M. S.; Cavaleiro, J. A. S. Tetrahedron Lett. 1995, 36, 5977–5978.
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Domingues, M.R.M., S.-Marques, M.G.O., Domingues, P. et al. Differentiation of positional isomers of nitro meso-tetraphenylporphyrins by tandem mass spectrometry. J Am Soc Mass Spectrom 12, 381–384 (2001). https://doi.org/10.1016/S1044-0305(01)00207-0
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DOI: https://doi.org/10.1016/S1044-0305(01)00207-0