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Investigation on Effect of Drug Dosing Regiments on Drug Delivery in Solid Tumor Via Lumped Parameter Modeling and Animal Experiments

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Abstract

This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tumor were developed to simulate time courses of average drug concentration (C t ) of tumor interstitium in two types of dosing regiments (i.e., single-shot and triple-shot ones). The two regiments were performed via antitumor drug, hydroxycamptothecin (Hcpt), on rats, to measure the drug concentration in the tumor. The simulations of the drug concentration in the tumor of the two dosing regiments were conducted and compared with the experimental data on rats. The coefficients in the models were investigated. It is concluded that the triple-shot method is more effective than that of single-shot injection. The present lumped-parameter model is quantitatively competent for drug delivery in solid tumor.

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Authors and Affiliations

  1. Department of Mechanics and Engineering Science, Fudan University, Shanghai, 200433, China

    Ci-xiu Gao & Shi-xiong Xu

  2. Huashan Hospital attached to Fudan University, Shanghai, 200040, China

    Yu-ping Jiang

  3. Jiangxi Medical School, Nanchang, 330006, China

    Jiang-long Tu

Authors
  1. Ci-xiu Gao
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  2. Shi-xiong Xu
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  3. Yu-ping Jiang
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  4. Jiang-long Tu
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Corresponding author

Correspondence to Ci-xiu Gao.

Additional information

Project suppoted by the National Natural Science Foundation of China (Grant No.10372026), the Shanghai Leading Academic Discipline Project (Grant No.B112).

Biography: GAO Ci-xiu (1984-), Female, Master

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Gao, Cx., Xu, Sx., Jiang, Yp. et al. Investigation on Effect of Drug Dosing Regiments on Drug Delivery in Solid Tumor Via Lumped Parameter Modeling and Animal Experiments. J Hydrodyn 21, 20–25 (2009). https://doi.org/10.1016/S1001-6058(08)60114-6

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  • DOI: https://doi.org/10.1016/S1001-6058(08)60114-6

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