Acta Mechanica Solida Sinica

, Volume 24, Issue 1, pp 27–51 | Cite as

Cell and molecular biomechanics: perspectives and challenges

  • Baohua Ji
  • Gang Bao


As an intriguing interdisciplinary research field, cell and molecular biomechanics is at the cutting edge of mechanics in general and biomechanics in particular. It has the potential to provide a quantitative understanding of how forces and deformation at tissue, cellular and molecular levels affect human health and disease. In this article, we review the recent advances in cell and molecular biomechanics, examine the available computational and experimental tools, and discuss important issues including protein deformation in mechanotransduction, cell deformation and constitutive behavior, cell adhesion and migration, and the associated models and theories. The opportunities and challenges in cell and molecular biomechanics are also discussed. We hope to provide readers a clear picture of the current status of this field, and to stimulate a broader interest in the applied mechanics community.

Key words

molecular biomechanics cell mechanics protein mechanics cell adhesion cell migration mechanotransduction 


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Copyright information

© The Chinese Society of Theoretical and Applied Mechanics and Technology 2011

Authors and Affiliations

  1. 1.Department of Applied MechanicsBeijing Institute of TechnologyBeijingChina
  2. 2.Department of Biomedical EngineeringGeorgia Institute of Technology and Emory UniversityAtlantaUSA

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