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Similarity of Insulin-Dependent Diabetics’ and Non-Insulin-Dependent Diabetics’ Levels of β-hCG and Unconjugated Estriol With Controls: No Need to Adjust as With Alpha-Fetoprotein

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Abstract

Objective

To determine if the same systematic alteration of serum values seen for alpha-fetoprotein (AFP) in diabetic patients is also seen for β-hCG and unconjugated estriol (uE3).

Methods

Serum AFP, β-hCG, and uE3 results were obtained in 18,639 patients for whom complete follow-up information was obtained. Patients were divided into euglycemic (n = 18,088), insulin-requiring diabetics (n = 104), and non-insulin-requiring diabetics (n = 437), as well as by race.

Results

The 20% adjustment used for AFP appropriately corrects serum values. No such systematic variation is seen for either β-hCG or uE3 by glycemic status or race.

Conclusion

No adjustment for β-hCG or uE3 is necessary for diabetes for biochemical screening programs.

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Authors and Affiliations

  1. Departments of Obstetrics and Gynecology, Molecular Medicine and Genetics, and Pathology, Wayne State University/Hutzel Hospital, 4707 St. Antoine Blvd., Detroit, MI, 48201, USA

    Mark I. Evans MD, Joseph E. O’Brien MD, Elena Dvorin PhD, Eric L. Krivchenia MS, Arie Drugan MD, Roderick F. Hume Jr. MD & Mark P. Johnson MD

  2. Department of Pathology, Columbia University, New York, New York, USA

    Mark I. Evans MD, Joseph E. O’Brien MD, Elena Dvorin PhD, Eric L. Krivchenia MS, Arie Drugan MD, Roderick F. Hume Jr. MD & Mark P. Johnson MD

  3. Corning/MetPath Inc., Teterboro, New Jersey, USA

    Mark I. Evans MD, Joseph E. O’Brien MD, Elena Dvorin PhD, Eric L. Krivchenia MS, Arie Drugan MD, Roderick F. Hume Jr. MD & Mark P. Johnson MD

  4. Auburn Hills, Michigan, USA

    Mark I. Evans MD, Joseph E. O’Brien MD, Elena Dvorin PhD, Eric L. Krivchenia MS, Arie Drugan MD, Roderick F. Hume Jr. MD & Mark P. Johnson MD

  5. Department of Obstetrics, Rambam Medical Center, Haifa, Israel

    Mark I. Evans MD, Joseph E. O’Brien MD, Elena Dvorin PhD, Eric L. Krivchenia MS, Arie Drugan MD, Roderick F. Hume Jr. MD & Mark P. Johnson MD

Authors
  1. Mark I. Evans MD
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  2. Joseph E. O’Brien MD
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  3. Elena Dvorin PhD
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  4. Eric L. Krivchenia MS
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  5. Arie Drugan MD
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  6. Roderick F. Hume Jr. MD
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  7. Mark P. Johnson MD
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Evans, M.I., O’Brien, J.E., Dvorin, E. et al. Similarity of Insulin-Dependent Diabetics’ and Non-Insulin-Dependent Diabetics’ Levels of β-hCG and Unconjugated Estriol With Controls: No Need to Adjust as With Alpha-Fetoprotein. Reprod. Sci. 3, 20–22 (1996). https://doi.org/10.1016/1071-5576(95)00043-7

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  • DOI: https://doi.org/10.1016/1071-5576(95)00043-7

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