Abstract
Optimization of both sensitivity and ionization softness for the Hewlett-Packard particle-beam liquid chromatography-mass spectrometry interface has been achieved by using a statistical experimental design with response surface modeling. Conditions for both optimized sensitivity and ionization softness were found to occur at 55-lb/in.2 nebulizer flow, 35°C desolvation chamber temperature with approximately 45% organic modifier in the presence of 0.02-F ammonium acetate and a liquid chromatography flow rate of 0.2 mL/min.
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Huang, S.K., Garza, N.R. Optimization of the Hewlett-Packard particle-beam liquid chromatography-mass spectrometry interface by statistical experimental design. J Am Soc Mass Spectrom 6, 507–512 (1995). https://doi.org/10.1016/1044-0305(95)00055-I
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DOI: https://doi.org/10.1016/1044-0305(95)00055-I