Abstract
This report describes a new high-resolution linear time-of-flight mass spectrometer that has been constructed at this institute. The instrument is used for investigations of both direct and matrix-assisted laser desorption/ionization of large molecules. A unique feature of this new instrument is the incorporation of a 10-cm postsource pulse-focusing region for enhancing the resolution of the detected ion signals. This technique can correct for both high initial ion translational energies and long durations of ion formation and is expected to be particularly well suited for laser desorption/ionization applications. Results of calculations are presented to illustrate the gains in mass resolution that may be expected for a variety of ion formation conditions. In addition, initial experimental results are presented that demonstrate the capability of this new instrument to produce high-resolution ion signals. Signals with mass resolutions as high as 2750 (full width at half maximum) have been obtained for both direct and matrix-assisted laser desorption/ionization signals.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Honinig, R. E.; Woolston, J. R. Appl. Phys. Lett. 1963, 2, 138.
For an early review see Conzemius, R. J.; Capellen, J. M. Int. J. Mass Specfrom. Ion Phys. 1980, 34, 197.
(a) Benninghoven, A., Ed. Springer Series in Chemical Physics 25: ion Formation from Organic Solids; Springer-Verlag: Berlin, 1983; pp. 190–244; (b) Benninghoven, A., Ed. Springer Proceedings in Physics 9: Ion Formation from Organic Solids IFOS III; Springer-Verlag: Berlin, 1986; pp. 142–162.
Van Vaeck, L.; Bennett, J.; Van Epsen, P.; Schweikert, E.; Gijbels, R.; Adams, F.; Lauwers, W. Org. Mass Spectrom. 1989, 24, 797.
Branan, D. M.; Hoffman, N. W.; McElroy, E. A.; Ramage, D. L.; Robbins, M. J.; Eyler, J. R.; Watson, C. H.; deFur, P.; Leary, J. A. Inorg. Chem. 1990, 29, 1915.
Karat, M.; Bachmann, D.; Bahr, LJ.; Hillenkamp, F. Int. J. Mass Spectrom. Ion Processes 1987, 78, 53.
Tanaka, K.; Waki, H.; Ido, Y.; Anita, S.; Yoshida, Y.; Yoshida, T. Rapid Commun. Mass Spectiom. 1988, 2, 151.
Karas, M.; Bahr, U.; lngendoh, A.; Hillenkamp, F. Anger. Chcm. Jnt. Ed. Engl. 1989, 28, 760.
(a) Karas, M.; Hillenkamp, F. Anal. Chem. 1988, 60, 2301; (b) Overberg, A.; Karat, M.; Hillenkamp, F. Xapid Commun. Mass Spectrom. 1991, 5, 128; (c) Overberg, A.; Karas, M.; Bahr, U.; Kaufmann, R.; Hillenkamp, F. Rapid Commun. Mass Spectrom. 1990, 4, 293.
(a) Beavis, R. C.; Chait, B. Rapid Commun. Mass. Spectrum. 1989, 3, 233; (b) Beavis, R. C.; Chait, B. Rapid Commun. Mass Spectrom. 1989, 3, 432; (c) Beavis, R. C.; Chait, B. Rapid Commun. Mass Specfrom. 1989, 3, 436; (d) Beavis, R. C.; Chait, B. T. Anal. Chem. 1990, 62, 1836.
(a) Spengler, B.; Cotter, R. J, Anal. Chem 1990, 62, 793; (b) Spengler, B.; Pan, Y.; Cotter, R. J.; Kan, L. Rapid Commun. Mass Spectrom. 1990, 4, 99.
(a) Salehpour, M.; Perera, I.; KjeIlberg, J.; Hedin, A.; Islamian, M. A.; Hakansson, P.; Sundqviit, B. U. R. Rapid Commun. Mass Spectrum. 1989, 3, 259; (b) Perera, 1. K.; Uxategui, E.; Hakansson, P.; Brinklmalm, G.; Pettersson, G.; Johansson, G.; Sundqvist, B. U. R. Rapid Commun. Mass Spectrom. 1990, 4, 285.
(a) Nelson, R. W.; Thomas, R. M.; Williams, P. Rapid Commun. Mass Spectrom. 1990, 4, 301; (b) Nelson, R.; Rainbow, M.; Lohr, D.; Williams, P. Science, 1989, 246, 1585.
(a) Huang, L. Q.; Conzemius, R. J.; Junk, G. A.; Houk, R. S. Anal. Chem. 1988, 60, 1490; (b) Denoyer, E.; Van Grieken, R.; Adams, F.; Nal-usch, D. Anal. Chem. 1982, 54, 26A.
(a) Karas, M.; Bahr, U.; Ingendoh, A.; Hiienkamp, F. Angtw. Chem. Int. Ed. Eng. 1989, 28, 760; (b) Kinsel, G. R.; Lindner, J.; Koester, C.; Zipperer, K.; Grotemeyer, J. Inst. Phys. Conf SKY. 1990, 124,155.
Beavis, R.; Chait, B. Rapid Commun. Mass Spectrom. 1989, 3, 233.
Spengler, B.; Kirsch, D.; Kaufmaxm, R. Rapid Commrm. Mass Specfrom. 1991, 5, 198.
(a) Karas. M.; Bahr. U.; Hassenbuereer, A.; Inxendoh, A.; Overberg, A.; Stahl, B; Strupat, K.; Hiliekamp, F. Proceedings of the 39th ASMS Conffrence on Mass Spectromety and Allied Topics; Nashville, TN, May 1991, p. 356; (b) Holle, A.; Mayer, F.; Schaefer, R.; Frey, R. Proceedings of the 39th ASMS Conjerence on Mass Spectmmetry and Allied Topics; Nashville, TN, 1991, p. 936.
(a) Price, D.; Milnes, G. J. lnt. I. Mass Spechom. Ion PYOC. 1990, 99, 1; (b) Campana, J. E. Anal. Insfrumen. 1987, 16, 1; (c) Le Beyec, Y. Adv. Mass Spectrom. 1989, 12, 126; (d) Boesl, U.; Weinkauf, R.; Schlag, E. W. Int. J. Mass Spectmm. Ion Proc. 1991, 212, 121.
Yang, M.; Reilly, J. P. Int. J. Mass Spectrom. Zen Proc. 1967, 75, 209.
(a) Van der Peyl, G. J. Q.; Van der Zande, W. J.; Kistemaker, P. G. Int. I. Mass Spectrom. Ion Phys. 1984, 62, 51; (b) Antonov, V. S.; Letokhov, V. S.; Shibanov, A. N. Appl. Phys. 1981, 25, 71; (c) Stoll, R.; Roellgen, F. W. 2. Naturforsch. A 1982, 37, 9.
Mauney, T.; Adams, F. Int. J. Mass Spectrom. Ion Proc. 1984, 59, 103.
(a) Ens, W.; Mao, Y.; Mayer, F.; Standing, K. G. Rapid Commun. Mass Specfrom. 1991, 5, 117; (b) Beavis, R. C.; Chait, B. T. Chem. Phys. Lett. 1991, 181, 479.
Beavis, R. C.; Chait, B. T. In Ion Formationfrom Organic Solids (IFOS V), Proceedings of the 5th International Conference; Hedm, A.; Sundqvist, B. U. R.; Benninghoven, A., Eds.; Wiley: Cbichester (England), 1990; pp. 125–130.
(a) Mamyrin, B. A.; Karataev, V. I.; Shmikk, D. V.; Zagulin, V. A. Sow. Phys. JETP 1973, 37, 45; (b) Karataev, V. I.; Mamyrin, B. A.; Shmikk, D. V. 500. Phys. Tech. Phys. 1972, 16, 1177; (c) Mamyrin, 8. A.; Shmikk, D. V. Son. Phys. JETP 1979, 49, 762.
Gohl, W.; Kutscher, R; Laue, H. J.; Wollnik, H. Inf. J. Muss Spechom. Ion. Phys. 1983, 48, 411.
(a) Boesl, U.; Neusser, H. J.; Weinkauf, R.; Schlag, E. W. J. Phys. Chem. 1982, 86, 4857; (b) Kuehlewind, J.; Neusser, H. J.; Schlag, E. W. Int. J. Mass Specfrom. Ion Phys. 1983, 51, 255; (c) Boesl, U.; Grotemeyer, J.; Walter, K.; Schlag, E. W. Anal. Instrum. 1987, 16, 151.
(a) Wiley, W. C.; McLaren, I. H. Reu. Sci. Ztwtrum. 1955, 26, 1150; (b) Erickson, E. D.; Yefchak, G. E.; Enke, C. G.; Holland, J. F. lnt. I. Mass Spectrom. Ion Proc. 1990, 97, 87.
(a) Muga, M. L. Anal. Znstrum. 1987, 16, 31; (b) Muga, M. L. U.S. Patent 4,458,149, July 3, 1984.
(a) Marable, N. L.; Sanzone, G. Int. J. Mass Spectrom. Zen Phys. 1974, 13, 185; (b) Browder, J. A.; Miller, R. L.; Thomas, W. A.; Sanzone, G. Znt. J. MQSS Spectrom. Zon Phys. 1981, 37,99.
Yefchak, G. E.; Enke, C. G.; Holland, J. F. Int. J. Mass Spectrom. Proc. 1989, 87, 313.
Kinsel, G. R.; Johnston, M. V. Int. J. Mass Spectrom. Ion Proc. 1989, 91, 157.
Kinsel, G. R.; Mowry, C. D.; McKeown, P. J.; Johnston, M. V. Int. J. hass Specbom. Ion Proc. 1991, 104, 35.
Author information
Authors and Affiliations
Additional information
An erratum to this article is available at http://dx.doi.org/10.1016/1044-0305(93)85012-M.
Rights and permissions
About this article
Cite this article
Kinsel, G.R., Grundwuermer, J.M. & Grotemeyer, J. High-resolution mass spectrometry of large molecules in a linear time-of-flight mass spectrometer. J Am Soc Mass Spectrom 4, 2–10 (1993). https://doi.org/10.1016/1044-0305(93)85036-W
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1016/1044-0305(93)85036-W