Abstract
In inductively coupled plasma-mass spectrometry the first-stage pressure and solvent characteristics can strongly influence spectral and nonspectroscopic interference effects. By manipulating the pressure and solvent load, one can regulate the degree of analyte signal suppression observed in the presence of high concentrations (> 10 mM) of concomitants. Importantly, the same operating conditions that eliminate the matrix effects maintain the analytical utility of the system. However, for some interferent-analyte combinations, the identity of the concomitant anion and subsequent pH of the solution determine whether the interference effects can be eliminated entirely. The first-stage pressure does not appear to significantly affect the oxide-ion and doubly charged ion ratios; the solvent characteristics are the dominant factors that dictate these ratios.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Ure, A. M.; Ellis, A, T.; Williams, J. G. J. Anal. At. Spectrom. 1988, 3, 175R.
Houk, R. S.; Thompson, J. J, Mass Spectrom. Rev, 1988, 7, 425.
Hieftje, G. M.; Vickers, G. H. Anal. Chim, Acta 1989, 216, 1.
4 Date, A. R,; Cheung, Y. Y.; Stuart, M. E. Spectrochim. Acta, Part B 1987, 42B, 3.
Wilson, D. A.; Vickers, G. H.; Hieftje, G. M, J. Anal. At, Spectrom. 1987, 2, 365,
Pickford, C. L Brown, R. M. Spectrochim. Acta, Part B 1986, 418, 183.
Gray, A. L. Spectrochim. Acta, Part B 1986, 41B, 151,
Gillson, G. R,; Douglas, D. J.; Fulford, J. E.; Halligan, K. W.; Tanner, S. D. Anal. Chem. 1988, 60, 1472.
Olivares, J. A.; Houk, R. S. Anal. Chem. 1986, 58, 20.
Crain, J. S.; Houk, R, S.; Smith, F. G. Spectrochim. Acta, Part B 1988, 43B, 1355.
Beauchemin, D.; McLaren, J. W.; Berman, S. S. Spectrochim. Acta, Part B 1987, 42B, 467.
Gregoire, D. C. Spectrochim. Acta, Part B 1987, 42B, 895.
Tan, S. H.; Horlick, G. J. Anal. At. Spectrom. 1987, 2, 745,
Gregoire, D. C. Appl. Spectrosc. 1987, 41, 897.
Thompson, J.J.; Houk, R. S. Appl. Spectrosc. 1987, 41, 801.
Longerich, H, P.; Fryer, B. J,; Strong, D. F.; Kantipuly, C. J. Spectrochim. Acta, Part B 1987, 42B, 75.
Olesik, J. W.; Williamson, E, J. Appl. Spectrosc. 1989, 43, 1223,
Gray, A. L.; Williams, J. G. J. Anal. At. Spectrom. 1987, 2, 599,
Vaughan, M, A.; Horlick, G. Appl. Spectrosc. 1986, 40, 434.
Vaughan, M. A.; Horlick, G. Appl, Spectrosc. 1987, 41, 523.
Wilson, D. A.; Vickers, G. H,; Hieftje, G. M.; Zander, A. T. Spectrochim. Acta, Part B 1987, 42B, 29.
Chambers, D. M.; Poehlman, J,; Yang, P.; Hieftje, G. M. Spectrochim. Acta, Part B, 1991, 46B, 741.
Deutsch, R. D.; Hieftje, G. M. Appl, Spectrosc. 1985, 39, 214.
Smith, T. R.; Denton, M. B. Appl. Spectrose. 1990, 44, 21,
Ross, B.S.; Chambers, D. M,; Vickers, G. H.; Yang, P.; Hieftje, G, M, J. Anal. At. Spectrom. 1990, 5, 351,
Dean, J, A.; Rains, T. C. Flame Emission and Atomic Absorption Spectroscopy, Vol. 2,; Marcel Dekker: New York, 1971; p 331.
Vickers, G. H.; Ross, B. S.; Hieftje, G, M. Appl. Spectrosc. 1989, 43, 1330,
Zhu, G.; Browner, R, F. J, Anal. At. Spectrom. 1988, 3, 781.
Hutton, R. c.; Eaton, A. N, J, Anal. At. Spectrom. 1987, 2, 595.
Browner, R. F.; Boom, A, W.; Smith, D. D. Anal. Chem. 1982, 54, 1411.
Novak, J. W.; Browner, R. F. Anal. Chem. 1980, 52, 792.
Routh, M, W. Spectrochim. Acta, Part B 1986, 41B, 39.
Ozeki, T.; Kihara, H,; Ikeda, S, Anal, Chem. 1988, 60, 2058.
Razaaiyaan, R.; Olesik, J. W,; Hieftje, G. M, Spectrochim. Acta, Part B 1985, 40B, 73.
Borowiec, J. A.; Boom, A, W.; Deltard, J. H.; Cresser, M, S.; Browner, R, F.; Matteson, M, J, Anal. Chem. 1980, 52, 1054.
Skogerboe, R. K.; Freeland, S. J. Appl. Spectrosc. 1985, 93, 925.
Lim, H. B.; Houk, R. S.; Crain, J. S. Spectrochim. Acta, Part B 1989, 44B, 989.
Gray, A. L.; Houk, R. S.; Williams, J. G, J, Anal. At. Spectrom. 1987, 2, 13.
Chambers, D, M.; Ross, B.S.; Hieftje, G, M. Spectrochim. Acta, Part B, 1991, 46B, 785.
Browner, R, F.; Zhu, G. J. Anal. At. Spectrom. 1987, 2, 543.
Koropchak, J. A.; Aryamanya-Mugisha, H. J. Anal. At, Spectrom. 1989, 4, 291.
Long, S, E.; Browner, R, F, Spectrochim. Acta, Part B 1988, 43B, 1461,
Gray, A, L. J. Anal. At. Spectrom. 1989, 4, 371.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ross, B.S., Hieftje, G.M. Selection of solvent load and first-stage pressure to reduce interference effects in inductively coupled plasma-mass spectrometry. J Am Soc Mass Spectrom 3, 128–138 (1992). https://doi.org/10.1016/1044-0305(92)87046-2
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1016/1044-0305(92)87046-2