Detection of femtomole and sub-femtomole levels of peptides by tandem magnetic sector/reflectron time-of-flight mass spectrometry and matrix-assisted laser desorption ionization

  • F. H. Strobel
  • T. Solouki
  • M. A. White
  • D. H. Russell


This article describes results of low-level (sub-femtomole) detection of peptides by matrix-assisted laser desorption ionization. The matrix-assisted laser desorption ionization method can be used for low-level detection of the parent ion, either [M + H]+ or [M + Na]+, and collision-induced dissociation of the parent ion can be performed at the picomole level. The instrument used for these studies is a novel high-performance magnetic sector (electric(E)/magnetic(B) sector)/reflectron time-of-flight (TOP) tandem mass spectrometer (EB/TOF).


Laser Shot Sinapic Acid Tandem Mass Spectrometer Arrival Time Distribution Deceleration Lens 
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Copyright information

© American Society for Mass Spectrometry 1991

Authors and Affiliations

  • F. H. Strobel
    • 1
  • T. Solouki
    • 1
  • M. A. White
    • 1
  • D. H. Russell
    • 1
  1. 1.Department of ChemistryTexas A & M UniversityCollege StationUSA

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