Abstract
Techniques are presented for mass-selective ion manipulation over a wide mass range in a three-dimensional quadrupole. The methods use an auxiliary, low-amplitude radio-frequency signal applied to the endcap electrodes. This signal is either held at a single frequency as the fundamental radio-frequency trapping amplitude is ramped or swept over a frequency range while the fundamental radio-frequency trapping amplitude is held at a fixed level. Ion isolation and ejection are demonstrated for ions formed within the ion trap using electron ionization and for ions injected into the ion trap formed either by an air-sustained glow discharge or by electrospray. Mass-selective ion ejection is used to reduce matrix-ion-induced space charge during ion injection, thereby producing signal enhancement for the detection of 2, 4, 6-trinitrotoluene in air. Mass-selective isolation of ions with mass-to-charge ratios above the normal operating range (m / z 650) for the ion trap is also demonstrated after injection of myoglobin ions formed via electrospray.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Stafford, G. C.. Kelley, P. E.; Syka, J. E. P.; Reynolds, W. E.; Todd, J.F. J. Int. J. Mass Spectrom. Ion Processes 1984, 60, 85.
Stafford, G. C, Kelley, P. E.; Stephens, D. R. U.S. Patent 4, 540, 884, 1985.
Kelley, P. E.; Stafford, G. c, Fies, W. J.; Syka, J. E. P.; McIver, R. T.; Hunter, R. L.; Todd, J. F. J.; Bexon, J. J. Proceedings of the 32nd Annual Conference on Mass Spectrometry and Allied Topics, San Antonio, 1984; p 505.
Dawson, P. H.; Whetten, N. R. AFCRL-69-0185, 1969.
Fullord, J. E.; March. R. E. Int. J. Mass Spectrom. Ion Phys. 1978, 26, 155.
Louris, J. N.; Cooks, R. G.; Syka, J. E. P.; Kelley, P. E.; Stafford, G. C., Todd, J. F. J. Anal. Chem. 1987, 59, 1677.
Louris, J. N.; Brodbelt-Lustig, J.S.; Cooks, R. G.; Glish, G. L.; Van Berkel, G. J.;McLuckey, S. A. Int. J. Mass Spectrom. Ion Processes 1990, 94, 15.
MCLuckey, S. A.; Glish, G. L.; Kelley, P. E. Anal. Chem. 1987, 59, 1670.
Tucker, D. B.; Hameister, C. H.; Bradshaw, S. C.. Hoek-man, D. J.; Weber-Grabau, M. Proceedings of the 36th ASMS Conference on Mass Spectrometry and Allied Topics, San Francisco. 1988; p 628.
Kaiser, R. E., Jr.: Cooks, R. G.; Moss, J.; Hemberger, P. H. RapidCommun. Mass Spectrom. 1989, 3, 50.
Kaiser, R. E.; Louris, J. N.; Amy, J. W.; Cooks, R. G. Rapid Commun. Mass Spectrom. 1989, 3, 225.
Van Berkel, G. J.; Glish, G. L.; McLuckey, S. A. Anal. Chem. 1990, 62, 1284.
March, R. E.; Hughes, R. J.; Quadrupole Storage Mass Spectrometry; Winefordner, J. D.; Kolthoff, I. M., Eds.; Chemical Analysis Series 102; Wiley: New York, 1989.
Fischer. E. Z. Phys. 1959, 156, 1.
Fulford, J. E.; Hoa, D.-N.; Hughes, R. J.; March, R. E.; Bonner, R. F.; Wong, G. J. J. Vac. Sci. Technol. 1980, 17, 829.
Todd, J.F. J.; Bexon, J.J.; Smith, R. D.; Weber-Grabau, M.; Kelley, P. E.; Syka, J. E. P.; Stafford, G. C.; Bradshaw, S. C. Proceedings 16th Meeting British Mass Spectrometry Society, York, U.K., 1987; p 206.
Kelley, P. E.; Syka, J. E. P.; Ceja, P. c.. Stafford, G. C.; Louris, J. N.; Grutzmacher, H. F.; Kuck, D.; Todd, J. F. J. Proceedings of the 34th Conference on Mass Spectrometry and Allied Topics, Cincinnati, 1986; p 963.
Syka, J. E. P.; Pies, W. J., Jr. Proceedings of the 35th Conference on Mass Spectrometry and Allied Topics, Denver, 1987; p 767.
McLuckey, S. A; Glish, G. L.; Asano, K. G. Anal. Chim. Acta 1989, 225, 25.
McLuckey, S. A.; Glish, G. L.; Asano, K. G.; Grant, B. C. Anal. Chem. 1988, 60, 2220.
Louris, J. N.; Amy, J. W.; Ridley, T. Y.; Cooks, R. G. Int. J. Mass Spectrom. Ion Processes 1989, 88, 97.
Pedder, R. E.; Yost, R. A.; Weber-Grabau, M. Proceedings of the 37th ASMS Conference on Mass Spectrometry and Allied Topics, Miami Beach, 1989; p 468.
Schwartz, J. C.; Cooks, R. G.; Weber-Grabau, M.; Kelley, P. E. Proceedings of the 36th ASMS Conference on Mass Spectrometry and Allied Topics, San Francisco, 1988; p 634.
Stafford, G. C.; Taylor, D. M.; Bradshaw, S. C.; Syka, J. E. P.; Uhrich, M. Proceedings of the 35th Conference on Mass Spectrometry and Allied Topics, Denver, 1987; p 775.
Todd, J. F. J.; Waldren, R. M.; Mather, R. E. Int. J. Mass Spectrom. Ion Phys. 1980, 34, 325.
Schwebel. C.; Moller, P. A.; Manh, P.-T. Rev. Phys. Appl. 1975, 10, 227.
McLuckey. S. A.; Van Berkel. G. J.; Glish, G. L. J. Am. Chem. Soc. 1990, 112, 5668
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McLuckey, S.A., Goeringer, D.E. & Glish, G.L. Selective ion isolation/rejection over a broad mass range in the quadrupole ion trap. J Am Soc Spectrom 2, 11–21 (1991). https://doi.org/10.1016/1044-0305(91)80056-D
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1016/1044-0305(91)80056-D