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Neurotherapeutics

, Volume 7, Issue 4, pp 366–377 | Cite as

Role of microglia in neurotrauma

  • David J. Loane
  • Kimberly R. Byrnes
Review Article

Summary

Microglia are the primary mediators of the immune defense system of the CNS and are integral to the subsequent inflammatory response. The role of microglia in the injured CNS is under scrutiny, as research has begun to fully explore how postinjury inflammation contributes to secondary damage and recovery of function. Whether microglia are good or bad is under debate, with strong support for a dual role or differential activation of microglia. Microglia release a number of factors that modulate secondary injury and recovery after injury, including pro- and anti-inflammatory cytokines, chemokines, nitric oxide, prostaglandins, growth factors, and Superoxide species. Here we review experimental work on the complex and varied responses of microglia in terms of both detrimental and beneficial effects. Addressed in addition are the effects of microglial activation in two examples of CNS injury: spinal cord and traumatic brain injury. Microglial activation is integral to the response of CNS tissue to injury. In that light, future research is needed to focus on clarifying the signals and mechanisms by which microglia can be guided to promote optimal functional recovery.

Key Words

Microglia spinal cord injury traumatic brain injury inflammation 

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Copyright information

© Springer 2010

Authors and Affiliations

  1. 1.Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research (STAR), National Study Center for Trauma and EMSUniversity of Maryland School of MedicineBaltimore
  2. 2.Room B2048, Department of Anatomy, Physiology and GeneticsUniformed Services University of the Health SciencesBethesda

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