, Volume 7, Issue 3, pp 302–306

Tourette syndrome: Gene expression as a tool to discover drug targets

Review Article

DOI: 10.1016/j.nurt.2010.05.007

Cite this article as:
Liao, I.H. & Sharp, F.R. Neurotherapeutics (2010) 7: 302. doi:10.1016/j.nurt.2010.05.007


Gene expression microarrays are a high-throughput, cost-effective method for measuring the expression of all genes in a sample. By comparing the expression patterns of healthy controls to diseased subjects, the genetic regulatory pathways underlying and affected by the disease can be elucidated. Furthermore, dysregulated genes are possible candidates for pharmaceutical therapy. Here, we consider the possibility of applying this approach to Tourette syndrome. We also review current theories of Tourette syndrome etiology and pharmacology.

Key Words

Tourette syndrome gene expression microarrays pharmacology 

Copyright information

© Springer 2010

Authors and Affiliations

  1. 1.Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute and Department of NeurologyUniversity of California at DavisSacramento

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