, Volume 6, Issue 4, pp 630–637 | Cite as

Postherpetic neuralgia: From preclinical models to the clinic

  • Ada Delaney
  • Lesley A. Colvin
  • Marie T. Fallon
  • Robert G. Dalziel
  • Rory Mitchell
  • Susan M. Fleetwood-Walker
Preclinical Models of Neuropathic Pain


Postherpetic neuralgia (PHN), a common complication of herpes zoster, which results from reactivation of varicella zoster virus, is a challenging neuropathic pain syndrome. The incidence and severity of herpes zoster and PHN increases with immune impairment or age and may become a greater burden both in terms of health economics and individual suffering. A clearer understanding of the underlying mechanisms of this disease and translation of preclinical outcomes to the clinic may lead to more efficacious treatment options. Here we give an overview of recent findings from preclinical models and clinical research on PHN.

Key Words

Postherpetic neuralgia herpes zoster varicella zoster virus animal model chronic pain analgesia 


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Copyright information

© Springer 2009

Authors and Affiliations

  • Ada Delaney
    • 1
  • Lesley A. Colvin
    • 2
  • Marie T. Fallon
    • 3
  • Robert G. Dalziel
    • 4
  • Rory Mitchell
    • 5
  • Susan M. Fleetwood-Walker
    • 1
  1. 1.Centre for NeuroregenerationUniversity of EdinburghUK
  2. 2.Department of Anaesthesia, Critical Care, and Pain MedicineUniversity of EdinburghEdinburghUK
  3. 3.Edinburgh Cancer Research Centre, Western General HospitalUniversity of EdinburghEdinburghUK
  4. 4.The Roslin Institute and Centre for Infectious DiseasesUniversity of EdinburghEdinburghUK
  5. 5.Centre for Integrative Physiology, College of Medicine and Veterinary MedicineUniversity of EdinburghEdinburghUK

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