Neurotherapeutics

, Volume 6, Issue 3, pp 558–569

Oncolytic viral therapy of malignant glioma

  • Jacqueline Nuss Parker
  • David F. Bauer
  • James J. Cody
  • James M. Markert
Review Article

Summary

Novel approaches to treatment of malignant glioma, the most frequently occurring primary brain tumor, have included the use of a wide range of oncolytic viral vectors. These vectors, either naturally tumor-selective, or engineered as such, have shown promise in the handful of phase I and phase II clinical trials conducted in recent years. The strategies developed for each of the different viruses currently being studied and the history of their development are summarized here. In addition, the results of clinical trials in patients and their implication for future trials are also discussed.

Key Words

Oncolytic viral therapy malignant glioma G207 HSV 1716 ONYX-015 adenovirus Reolysin vaccinia Newcastle disease virus measles virus 

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2009

Authors and Affiliations

  • Jacqueline Nuss Parker
    • 1
  • David F. Bauer
    • 2
  • James J. Cody
    • 1
  • James M. Markert
    • 2
  1. 1.Department of Pediatrics, Division of Infectious DiseasesUniversity of Alabama at BirminghamBirmingham
  2. 2.Department of Surgery, Division of NeurosurgeryUniversity of Alabama at BirminghamBirmingham

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