Neurotherapeutics

, Volume 4, Issue 3, pp 316–329 | Cite as

Diffusion tensor imaging of the brain

  • Andrew L. Alexander
  • Jee Eun Lee
  • Mariana Lazar
  • Aaron S. Field
Article

Summary

Diffusion tensor imaging (DTI) is a promising method for characterizing microstructural changes or differences with neuropathology and treatment. The diffusion tensor may be used to characterize the magnitude, the degree of anisotropy, and the orientation of directional diffusion. This review addresses the biological mechanisms, acquisition, and analysis of DTI measurements. The relationships between DTI measures and white matter pathologic features (e.g., ischemia, myelination, axonal damage, inflammation, and edema) are summarized. Applications of DTI to tissue characterization in neurotherapeutic applications are reviewed. The interpretations of common DTI measures (mean diffusivity, MD; fractional anisotropy, FA; radial diffusivity, Dr; and axial diffusivity, Da) are discussed. In particular, FA is highly sensitive to microstructural changes, but not very specific to the type of changes (e.g., radial or axial). To maximize the specificity and better characterize the tissue microstructure, future studies should use multiple diffusion tensor measures (e.g., MD and FA, or Da and Dr).

Key Words

Diffusion tensor imaging white matter diffusivity MRI brain fractional anisotropy 

References

  1. 1.
    Basser PJ, Mattiello J, LeBihan D. Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 1994;103: 247–254.PubMedGoogle Scholar
  2. 2.
    Basser PJ, Mattiello J, LeBihan D. MR diffusion tensor spectroscopy and imaging. Biophys J 1994;66: 259–267.PubMedGoogle Scholar
  3. 3.
    Conturo TE, Lori NF, Cull TS, et al. Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci U S A 1999;96: 10422–10427.PubMedGoogle Scholar
  4. 4.
    Mori S, Crain BJ, Chacko VP, van Zijl PC. Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 1999;45: 265–269.PubMedGoogle Scholar
  5. 5.
    Basser PJ, Pajevic S, Pierpaoli C, Duda J, Aldroubi A. In vivo tractography using DT-MRI data. Magn Reson Med 2000;44: 625–632.PubMedGoogle Scholar
  6. 6.
    Einstein A. Investigations on the theory of the Brownian movement. New York: Dover Publications, 1956: 17.Google Scholar
  7. 7.
    Le Bihan D. Molecular diffusion, tissue microdynamics and microstructure. NMR Biomed 1995;8: 375–386.PubMedGoogle Scholar
  8. 8.
    Moseley ME, Cohen Y, Kucharczyk J, et al. Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. Radiology 1990;176: 439–445.PubMedGoogle Scholar
  9. 9.
    Chenevert T, Brunberg J, Pipe J. Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo. Radiology 1990;177: 401–405.PubMedGoogle Scholar
  10. 10.
    Norris DG. Implications of bulk motion for diffusion-weighted imaging experiments: effects, mechanisms, and solutions. J Magn Reson Imaging 2001;13: 486–495.PubMedGoogle Scholar
  11. 11.
    Mansfield P. Real-time echo-planar imaging by NMR. Br Med Bull 1984;40: 187–190.PubMedGoogle Scholar
  12. 12.
    Turner R, Le Bihan D, Maier J, Vavrek R, Hedges LK, Pekar J. Echo-planar imaging of intravoxel incoherent motion. Radiology 1990;177: 407–414.PubMedGoogle Scholar
  13. 13.
    Jezzard P, Balaban RS. Collection for geometric distortion in echo planar images from BO field variations. Magn Reson Med 1995;34: 65–73.PubMedGoogle Scholar
  14. 14.
    Haselgrove JC, Moore JR. Collection for distortion of echo-planar images used to calculate the apparent diffusion coefficient. Magn Reson Med 1996;36: 960–964.PubMedGoogle Scholar
  15. 15.
    Jezzard P, Barnett AS, Pierpaoli C. Characterization of and correction for eddy current artifacts in echo planar diffusion imaging. Magn Reson Med 1998;39: 801–812.PubMedGoogle Scholar
  16. 16.
    Alexander AL, Tsuruda JS, Parker DL. Elimination of eddy current artifacts in diffusion-weighted echo-planar images: the use of bipolar gradients. Magn Reson Med 1997;38: 1016–1021.PubMedGoogle Scholar
  17. 17.
    Reese TG, Heid O, Weisskoff RM, Wedeen VJ. Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo. Magn Reson Med 2003;49: 177–182.PubMedGoogle Scholar
  18. 18.
    Andersson JL, Skare S. A model-based method for retrospective collection of geometric distortions in diffusion-weighted EPI. Neuroimage 2002;16: 177–199.PubMedGoogle Scholar
  19. 19.
    Rohde GK, Bamett AS, Basser PJ, Marenco S, Pierpaoli C. Comprehensive approach for collection of motion and distortion in diffusion-weighted MRI. Magn Reson Med 2004;51: 103–114.PubMedGoogle Scholar
  20. 20.
    Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P. SENSE: sensitivity encoding for fast MRI. Magn Reson Med 1999;42: 952–962.PubMedGoogle Scholar
  21. 21.
    Alexander AL, Lee JE, Wu YC, Field AS. Comparison of diffusion tensor imaging measurements at 3.0 T versus 1.5 T with and without parallel imaging. Neuroimaging Clin N Am 2006;16: 299–309, xi.PubMedGoogle Scholar
  22. 22.
    Jaermann T, Crelier G, Pruessmann KP, et al. SENSE-DTI at 3 T. Magn Reson Med 2004;51: 230–236.PubMedGoogle Scholar
  23. 23.
    Jones DK, Williams SC, Gasston D, Horsfield MA, Simmons A, Howard R. Isotropic resolution diffusion tensor imaging with whole brain acquisition in a clinically acceptable time. Hum Brain Mapp 2002;15: 216–230.PubMedGoogle Scholar
  24. 24.
    Shrager RI, Basser PJ. Anisotropically weighted MRI. Magn Reson Med 1998;40: 160–165.PubMedGoogle Scholar
  25. 25.
    Papadakis NG, Xing D, Huang CL, Hall LD, Carpenter TA. A comparative study of acquisition schemes for diffusion tensor imaging using MRI. J Magn Reson 1999;137: 67–82.PubMedGoogle Scholar
  26. 26.
    Basser PJ, Pierpaoli C. A simplified method to measure the diffusion tensor from seven MR images. Magn Reson Med 1998; 39: 928–934.PubMedGoogle Scholar
  27. 27.
    Jones DK, Horsfield MA, Simmons A. Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn Reson Med 1999;42: 515–525.PubMedGoogle Scholar
  28. 28.
    Shimony JS, McKinstry RC, Akbudak E, et al. Quantitative diffusion-tensor anisotropy brain MR imaging: normative human data and anatomic analysis. Radiology 1999;212: 770–784.PubMedGoogle Scholar
  29. 29.
    Hasan K, Parker DL, Alexander AL. Comparison of gradient encoding schemes for diffusion-tensor MRI. J Magn Reson Imaging 2001;13: 769–780.PubMedGoogle Scholar
  30. 30.
    Jones DK. The effect of gradient sampling schemes on measures derived from diffusion tensor MRI: a Monte Carlo study. Magn Reson Med 2004;51: 807–815.PubMedGoogle Scholar
  31. 31.
    Pierpaoli C, Basser PJ. Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 1996;36: 893–906.PubMedGoogle Scholar
  32. 32.
    Alexander AL, Hasan K, Lazar M, Tsuruda JS, Parker DL. Analysis of partial volume effects in diffusion-tensor MRI. Magn Reson Med 2001;45: 770–780.PubMedGoogle Scholar
  33. 33.
    Koay CG, Chang LC, Carew JD, Pierpaoli C, Basser PJ. A unifying theoretical and algorithmic framework for least squares methods of estimation in diffusion tensor imaging. J Magn Reson 2006;182: 115–125.PubMedGoogle Scholar
  34. 34.
    Basser PJ, Pierpaoli C. Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 1996;111: 209–219.PubMedGoogle Scholar
  35. 35.
    Conturo TE, McKinstry RC, Akbudak E, Robinson BH. Encoding of anisotropic diffusion with tetrahedral gradients: a general mathematical diffusion formalism and experimental results. Magn Reson Med 1996;35: 399–412.PubMedGoogle Scholar
  36. 36.
    Westin CF, Maier SE, Mamata H, Nabavi A, Jolesz FA, Kikinis R. Processing and visualization for diffusion tensor MRI. Med Image Anal 2002;6: 93–108.PubMedGoogle Scholar
  37. 37.
    Pierpaoli C, Jezzard P, Basser PJ, Bamett A, Di Chiro G. Diffusion tensor MR imaging of the human brain. Radiology 1996; 201: 637–648.PubMedGoogle Scholar
  38. 38.
    Ulug AM, van Zijl PJ. Orientation-independent diffusion imaging without tensor diagonalization: anisotropy definitions based on physical attributes of the diffusion ellipsoid. J Magn Reson Imaging 1999;9: 804–813.PubMedGoogle Scholar
  39. 39.
    Alexander AL, Hasan K, Kindlmann G, Parker DL, Tsuruda JS. A geometric comparison of diffusion anisotropy measures. Magn Reson Med 2000;44: 283–291.PubMedGoogle Scholar
  40. 40.
    Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, Cross AH. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002;17: 1429–1436.PubMedGoogle Scholar
  41. 41.
    Makris N, Worth AJ, Sorensen AG, et al. Morphometry of in vivo human white matter association pathways with diffusion-weighted magnetic resonance imaging. Ann Neurol 1997;42: 951–962.PubMedGoogle Scholar
  42. 42.
    Pajevic S, Pierpaoli C. Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain. Magn Reson Med 1999;42: 526–540.PubMedGoogle Scholar
  43. 43.
    Witwer BP, Moftakhar R, Hasan KM, et al. Diffusion-tensor imaging of white matter tracts in patients with cerebral neoplasm. J Neurosurg 2002;97: 568–575.PubMedGoogle Scholar
  44. 44.
    Lazar M, Alexander AL, Thottakara PJ, Badie B, Field AS. White matter reorganization after surgical resection of brain tumors and vascular malformations. AJNR Am J Neuroradiol 2006;27: 1258–1271.PubMedGoogle Scholar
  45. 45.
    Wu YC, Field AS, Chung MK, Badie B, Alexander AL. Quantitative analysis of diffusion tensor orientation: theoretical framework. Magn Reson Med 2004;52: 1146–1155.PubMedGoogle Scholar
  46. 46.
    Basser PJ, Pajevic S. Statistical artifacts in diffusion tensor MRI (DT-MRI) caused by background noise. Magn Reson Med 2000; 44: 41–50.PubMedGoogle Scholar
  47. 47.
    Mori S, Kaufmann WE, Davatzikos C, et al. Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magn Reson Med 2002;47: 215–223.PubMedGoogle Scholar
  48. 48.
    Catani M, Howard RJ, Pajevic S, Jones DK. Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 2002;17: 77–94.PubMedGoogle Scholar
  49. 49.
    Lazar M, Weinstein DM, Tsuruda JS, et al. White matter tractography using tensor deflection. Hum Brain Mapp 2003;18: 306–321.PubMedGoogle Scholar
  50. 50.
    Stieltjes B, Kaufmann WE, van Zijl PCM, et al. Diffusion tensor imaging and axonal tracking in the human brain. Neuroimage 2001;14: 723–735.PubMedGoogle Scholar
  51. 51.
    Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S. Fiber tract-based atlas of human white matter anatomy. Radiology 2004;230: 77–87.PubMedGoogle Scholar
  52. 52.
    Jellison BJ, Field AS, Medow J, Lazar M, Salamat MS, Alexander AL. Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. AJNR Am J Neuroradiol 2004;25: 356–369.PubMedGoogle Scholar
  53. 53.
    Tuch DS, Reese TG, Wiegell MR, Wedeen VJ. Diffusion MRI of complex neural architecture. Neuron 2003;40: 885–895.PubMedGoogle Scholar
  54. 54.
    Frank LR. Characterization of anisotropy in high angular resolution diffusion-weighted MRI. Magn Reson Med 2002;47: 1083–1099.PubMedGoogle Scholar
  55. 55.
    Alexander DC, Barker GJ, Arridge SR. Detection and modeling of non-Gaussian apparent diffusion coefficient profiles in human brain data. Magn Reson Med 2002;48: 331–340.PubMedGoogle Scholar
  56. 56.
    Assaf Y, Basser PJ. Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain. Neuroimage 2005;27: 48–58.PubMedGoogle Scholar
  57. 57.
    Wedeen VJ, Hagmann P, Tseng WY, Reese TG, Weisskoff RM. Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging. Magn Reson Med 2005;54: 1377–1386.PubMedGoogle Scholar
  58. 58.
    Hagmann P, Reese TG, Tseng WYI, Meuli R, Thirian JP, Wedeen VJ. Diffusion spectrum imaging tractography in complex cerebral white matter: an investigation of the centrum semiovale [Abstract]. Proc ISMRM 12 Kyoto 2004;623.Google Scholar
  59. 59.
    Alexander AL, Lee JE, Lazar M, et al. Diffusion tensor imaging of the corpus callosum in Autism. Neuroimage 2007;34: 61–73.PubMedGoogle Scholar
  60. 60.
    Skare S, Andersson JL. On the effects of gating in diffusion imaging of the brain using single shot EPI. Magn Reson Imaging 2001;19: 1125–1128.PubMedGoogle Scholar
  61. 61.
    Frank LR. Anisotropy in high angular resolution diffusion-weighted MRI. Magn Reson Med 2001;45: 935–939.PubMedGoogle Scholar
  62. 62.
    van Gelderen P, de Vleeschouwer MH, DesPres D, et al. Water diffusion and acute stroke. Magn Reson Med 1994;31: 154–163.PubMedGoogle Scholar
  63. 63.
    Liu Y, D’Arceuil HE, Westmoreland S, et al. Serial diffusion tensor MRI after transient and permanent cerebral ischemia in nonhuman primates. Stroke 2007;38: 138–145.PubMedGoogle Scholar
  64. 64.
    Sorensen AG, Wu O, Copen WA, et al. Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging. Radiology 1999;212: 785–792.PubMedGoogle Scholar
  65. 65.
    Yang Q, Tress BM, Barber PA, et al. Serial study of apparent diffusion coefficient and anisotropy in patients with acute stroke. Stroke 1999;30: 2382–2390.PubMedGoogle Scholar
  66. 66.
    Beaulieu C, Allen PS. Determinants of anisotropic water diffusion in nerves. Magn Reson Med 1994;31: 394–400.PubMedGoogle Scholar
  67. 67.
    Neil JJ, Shiran SI, McKinstry RC, et al. Normal brain in human newboms: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging. Radiology 1998; 209: 57–66.PubMedGoogle Scholar
  68. 68.
    Suzuki Y, Matsuzawa H, Kwee IL, Nakada T. Absolute eigenvalue diffusion tensor analysis for human brain maturation. NMR Biomed 2003;16: 257–260.PubMedGoogle Scholar
  69. 69.
    Tyszka JM, Readhead C, Bearer EL, Pautler RG, Jacobs RE. Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant. Neuroimage 2006; 29: 1058–1065.PubMedGoogle Scholar
  70. 70.
    Song SK, Yoshino J, Le TQ, et al. Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 2005; 26: 132–140.PubMedGoogle Scholar
  71. 71.
    Harsan LA, Poulet P, Guignard B, et al. Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging. J Neurosci Res 2006;83: 392–402.PubMedGoogle Scholar
  72. 72.
    Sun SW, Liang HF, Trinkaus K, Cross AH, Armstrong RC, Song SK. Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum. Magn Reson Med 2006;55: 302–308.PubMedGoogle Scholar
  73. 73.
    Henry RG, Oh J, Nelson SJ, Pelletier D. Directional diffusion in relapsing-remitting multiple sclerosis: a possible in vivo signature of Wallerian degeneration. J Magn Reson Imaging 2003;18: 420–426.PubMedGoogle Scholar
  74. 74.
    Choi SJ, Lim KO, Monteiro I, Reisberg B. Diffusion tensor imaging of frontal white matter microstructure in early Alzheimer’s disease: a preliminary study. J Geriatr Psychiatry Neurol 2005;18: 12–19.PubMedGoogle Scholar
  75. 75.
    Assaf Y, Ben-Sira L, Constantini S, Chang LC, Beni-Adani L. Diffusion tensor imaging in hydrocephalus: initial experience. AJNR Am J Neuroradiol 2006;27: 1717–1724.PubMedGoogle Scholar
  76. 76.
    Concha L, Gross DW, Wheatley BM, Beaulieu C. Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients. Neuroimage 2006; 32: 1090–1099.PubMedGoogle Scholar
  77. 77.
    Gross DW, Concha L, Beaulieu C. Extratemporal white matter abnormalities in mesial temporal lobe epilepsy demonstrated with diffusion tensor imaging. Epilepsia 2006;47: 1360–1363.PubMedGoogle Scholar
  78. 78.
    Moeller FG, Hasan KM, Steinberg JL, et al. Diffusion tensor imaging eigenvalues: preliminary evidence for altered myelin in cocaine dependence. Psychiatry Res 2007;154: 253–258.PubMedGoogle Scholar
  79. 79.
    Tievsky AL, Ptak T, Farkas J. Investigation of apparent diffusion coefficient and diffusion tensor anisotropy in acute and chronic multiple sclerosis lesions. AJNR Am J Neuroradiol 1999;20: 1491–1499.PubMedGoogle Scholar
  80. 80.
    Werring DJ, Clark CA, Barker GJ, Thompson AJ, Miller DH. Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology 1999;52: 1626–1632.PubMedGoogle Scholar
  81. 81.
    Field AS, Alexander AL. Diffusion tensor imaging in cerebral tumor diagnosis and therapy. Top Magn Reson Imaging 2004;15: 315–324.PubMedGoogle Scholar
  82. 82.
    Laundre BJ, Jellison BJ, Badie B, Alexander AL, Field AS. Diffusion tensor imaging of the corticospinal tract before and after mass resection as correlated with clinical motor findings: preliminary data. AJNR Am J Neuroradiol 2005;26: 791–796.PubMedGoogle Scholar
  83. 83.
    Gauvain KM, McKinstry RC, Mukherjee P, et al. Evaluating pediatric brain tumor cellularity with diffusion-tensor imaging. AJR Am J Roentgenol 2001;177: 449–454.PubMedGoogle Scholar
  84. 84.
    Guo AC, Cummings TJ, Dash RC, Rovenzale JM. Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology 2002: 224: 177–183.PubMedGoogle Scholar
  85. 85.
    Beppu T, Inoue T, Shibata Y, et al. Measurement of fractional anisotropy using diffusion tensor MRI in supratentorial astrocytic tumors. J Neurooncol 2003;63: 109–116.PubMedGoogle Scholar
  86. 86.
    Beppu T, Inoue T, Shibata Y, et al. Fractional anisotropy value by diffusion tensor magnetic resonance imaging as a predictor of cell density and proliferation activity of glioblastomas. Surg Neurol 2005;63: 56–61.PubMedGoogle Scholar
  87. 87.
    Lu S, Ahn D, Johnson G, Law M, Zagzag D, Grossman RI. Diffusion-tensor MR imaging of intracranial neoplasia and associated peritumoral edema: introduction of the tumor infiltration index. Radiology 2004;232: 221–228.PubMedGoogle Scholar
  88. 88.
    Tropine A, Vucurevic G, Delani P, et al. Contribution of diffusion tensor imaging to delineation of gliomas and glioblastomas. J Magn Reson Imaging 2004;20: 905–912.PubMedGoogle Scholar
  89. 89.
    Tsuchiya K, Fujikawa A, Nakajima M, Honya K. Differentiation between solitary brain metastasis and high-grade glioma by diffusion tensor imaging. Br J Radiol 2005;78: 533–537.PubMedGoogle Scholar
  90. 90.
    Morita K, Matsuzawa H, Fujii Y, Tanaka R, Kwee IL, Nakada T. Diffusion tensor analysis of peritumoral edema using lambda chart analysis indicative of the heterogeneity of the microstructure within edema. J Neurosurg 2005;102: 336–341.PubMedGoogle Scholar
  91. 91.
    Yung A, Poon G, Qiu D, et al. White matter volume and anisotropy in preterm children: A pilot study of neurocognitive correlates. Pediatr Res 2007 [Epub ahead of print].Google Scholar
  92. 92.
    Muller MJ, Greveras D, Weiblich C, et al. Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI. Neurobiol Aging 2007;28: 398–403.PubMedGoogle Scholar
  93. 93.
    Alexopoulos GS, Kiosses DN, Choi SJ, Murphy CF, Lim KO. Frontal white matter microstructure and treatment response of late-life depression: a preliminary study. Am J Psychiatry 2002; 159: 1929–1932.PubMedGoogle Scholar
  94. 94.
    O’Sullivan M, Morris RG, Huckstep B, Jones DK, Williams SC, Markus HS. Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis. J Neurol Neurosurg Psychiatry 2004;75: 441–447.PubMedGoogle Scholar
  95. 95.
    Holtmannspotter M, Peters N, Opherk C, et al. Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study. Stroke 2005;36: 2559–2565.PubMedGoogle Scholar
  96. 96.
    Wardlaw JM, Keir SL, Bastin ME, Armitage PA, Rana AK. Is diffusion imaging appearance an independent predictor of outcome after ischemic stroke? Neurology 2002;59: 1381–1387.PubMedGoogle Scholar
  97. 97.
    Stinear CM, Barber PA, Smale PR, Coxon JP, Fleming MK, Byblow WD. Functional potential in chronic stroke patients depends on corticospinal tract integrity. Brain 2007;130: 170–180.PubMedGoogle Scholar
  98. 98.
    Lin X, Tench CR, Morgan PS, Niepel G, Constantinescu CS. ‘Importance sampling’ in MS: use of diffusion tensor tractography to quantify pathology related to specific impairment. J Neurol Sci 2005;237: 13–19.PubMedGoogle Scholar
  99. 99.
    Yu CS, Li KC, Xuan Y, Ji XM, Qin W. Diffusion tensor tractography in patients with cerebral tumors: a helpful technique for neurosurgical planning and postoperative assessment. Eur J Radiol 2005;56: 197–204.PubMedGoogle Scholar
  100. 100.
    Powell HW, Parker GJ, Alexander DC, et al. MR tractography predicts visual field defects following temporal lobe resection. Neurology 2005;65: 596–599.PubMedGoogle Scholar
  101. 101.
    Mamata Y, Mamata H, Nabavi A, et al. Intraoperative diffusion imaging on a 0.5 Tesla interventional scanner. J Magn Reson Imaging 2001;13: 115–119.PubMedGoogle Scholar
  102. 102.
    Nimsky C, Ganslandt O, Hastreiter P, et al. Intraoperative diffusion-tensor MR imaging: shifting of white matter tracts during neurosurgical procedures—initial experience. Radiology 2005;234: 218–225.PubMedGoogle Scholar
  103. 103.
    Nimsky C, Ganslandt O, Merhof D, Sorensen AG, Fahlbusch R. Intraoperative visualization of the pyramidal tract by diffusion-tensor-imaging-based fiber tracking. Neuroimage 2006;30: 1219–1229.PubMedGoogle Scholar
  104. 104.
    Salvan CV, Ulmer JL, Mueller WM, Krouwer HG, Rost RW, Stroe GO. Presurgical and intraoperative mapping of the motor system in congenital truncation of the precentral gyrus. AJNR Am J Neuroradiol 2006;27: 493–497.PubMedGoogle Scholar
  105. 105.
    Wakamoto H, Eluvathingal TJ, Makki M, Juhasz C, Chugani HT. Diffusion tensor imaging of the corticospinal tract following cerebral hemispherectomy. J Child Neurol 2006;21: 566–571.PubMedGoogle Scholar
  106. 106.
    Wieshmann UC, Symms MR, Clark CA, et al. Wallerian degeneration in the optic radiation after temporal lobectomy demonstrated in vivo with diffusion tensor imaging. Epilepsia 1999;40: 1155–1158.PubMedGoogle Scholar
  107. 107.
    Khong PL, Kwong DL, Chan GC, Sham JS, Chan FL, Ooi GC. Diffusion-tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medullo-blastoma: a pilot study. AJNR Am J Neuroradiol 2003;24: 734–740.PubMedGoogle Scholar
  108. 108.
    Qiu D, Leung LH, Kwong DL, Chan GC, Khong PL. Mapping radiation dose distribution on the fractional anisotropy map: applications in the assessment of treatment-induced white matter injury. Neuroimage 2006;31: 109–115.PubMedGoogle Scholar
  109. 109.
    Sundgren PC, Fan X, Weybright P, et al. Differentiation of recurrent brain tumor versus radiation injury using diffusion tensor imaging in patients with new contrast-enhancing lesions. Magn Reson Imaging 2006;24: 1131–1142.PubMedGoogle Scholar
  110. 110.
    Mabbott DJ, Noseworthy MD, Bouffet E, Rockel C, Laughlin S. Diffusion tensor imaging of white matter after cranial radiation in children for medulloblastoma: correlation with IQ. Neurooncology 2006;8: 244–252.Google Scholar
  111. 111.
    Khong PL, Leung LH, Fung AS, et al. White matter anisotropy in post-treatment childhood cancer survivors: preliminary evidence of association with neurocognitive function. J Clin Oncol 2006; 24: 884–890.PubMedGoogle Scholar
  112. 112.
    Blood AJ, Tuch DS, Makris N, Makhlouf ML, Sudarsky LR, Sharma N. White matter abnormalities in dystonia normalize after botulinum toxin treatment. Neuroreport 2006;17: 1251–1255.PubMedGoogle Scholar
  113. 113.
    Sinha S, Bastin ME, Wardlaw JM, Armitage PA, Whittle IR. Effects of dexamethasone on peritumoural oedematous brain: a DT-MRI study. J Neurol Neurosurg Psychiatry 2004;75: 1632–1635.PubMedGoogle Scholar
  114. 114.
    Jiang Q, Zhang ZG, Ding GL, et al. MRI detects white matter reorganization after neural progenitor cell treatment of stroke. Neuroimage 2006;32: 1080–1089.PubMedGoogle Scholar
  115. 115.
    Khachaturian MH, Wisco JJ, Tuch DS. Boosting the sampling efficiency of q-Ball imaging using multiple wavevector fusion. Magn Reson Med 2007;57: 289–296.PubMedGoogle Scholar
  116. 116.
    Wu Y-C, Alexander AL. Hybrid diffusion imaging. Neuroimage 2007 March 24 [Epub ahead of print].Google Scholar
  117. 117.
    Peled S, Friman O, Jolesz F, Westin CF. Geometrically constrained two-tensor model for crossing tracts in DWI. Magn Reson Imaging 2006;24: 1263–1270.PubMedGoogle Scholar
  118. 118.
    Anderson AW. Measurement of fiber orientation distributions using high angular resolution diffusion imaging. Magn Reson Med 2005;54: 1194–1206.PubMedGoogle Scholar
  119. 119.
    Behrens TE, Berg HJ, Jbabdi S, Rushworth MF, Woolrich MW. Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? Neuroimage 2007;34: 144–155.PubMedGoogle Scholar
  120. 120.
    Mulkern RV, Gudbjartsson H, Westin CF, et al. Multi-component apparent diffusion coefficients in human brain. NMR Biomed 1999;12: 51–62.PubMedGoogle Scholar
  121. 121.
    Bennett KM, Schmainda KM, Bennett RT, Rowe DB, Lu H, Hyde JS. Characterization of continuously distributed cortical water diffusion rates with a stretched-exponential model. Magn Reson Med 2003;50: 727–734.PubMedGoogle Scholar
  122. 122.
    Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. Diffusional kurtosis imaging: the quantification of non-Gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med 2005;53: 1432–1440.PubMedGoogle Scholar

Copyright information

© Springer New York 2007

Authors and Affiliations

  • Andrew L. Alexander
    • 1
    • 2
    • 5
  • Jee Eun Lee
    • 1
    • 2
  • Mariana Lazar
    • 5
    • 6
  • Aaron S. Field
    • 3
    • 4
  1. 1.Department of Medical PhysicsUniversity of Wisconsin-MadisonMadison
  2. 2.Department of PsychiatryUniversity of Wisconsin-MadisonMadison
  3. 3.Department of RadiologyUniversity of Wisconsin-MadisonMadison
  4. 4.Department of Biomedical EngineeringUniversity of Wisconsin-MadisonMadison
  5. 5.Waisman Laboratory for Brain Imaging and Behavior, Waisman CenterUniversity of Wisconsin-MadisonMadison
  6. 6.Center for Biomedical Imaging, Radiology DepartmentNew York University School of MedicineNew York

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