Journal of Nuclear Cardiology

, Volume 14, Issue 4, pp 555–565 | Cite as

Clinical results of a novel wide beam reconstruction method for shortening scan time of Tc-99m cardiac SPECT perfusion studies

  • Salvador Borges-Neto
  • Robert A. Pagnanelli
  • Linda K. Shaw
  • Emily Honeycutt
  • Shuli C. Shwartz
  • George L. Adams
  • Ralph Edward Coleman
Original Articles

Abstract

Background

Newly developed reconstruction algorithms enable the acquisition of images at half of the scan time while maintaining image quality. The purpose of this investigation was to evaluate a novel wide beam reconstruction (WBR) method developed by UltraSPECT for decreasing scan times and to compare it with filtered backprojection (FBP), which is the technique routinely used.

Methods and Results

Phantom and clinical studies were performed. Hot and cold sphere and cardiac phantom acquisitions were reconstructed via WBR, FBP, and ordered-subsets expectation maximization. Fifty patients were prospectively studied by use of both a standard and a short protocol. The short protocol was performed first on 29 of 50 patients via 8-frame gated technetium 99m stress single photon emission computed tomography and low-energy high-resolution collimators. Stress Tc-99m studies (30–45 mCi) were scanned for 20 seconds per frame. For the short protocol, all parameters remained constant except for the time per frame, which was reduced by 50% on Tc-99m studies. All resting Tc-99m scans (36/50 patients) were processed with FBP for the standard full-scan time studies and with WBR for the short scan studies. The images were interpreted by use of a 17-segment model and 5-degree severity score, and the perfusion and functional variables were determined. Distributions including mean, median, and interquartile ranges were examined for all variables. The differences (FBP-WBR) were computed for all variables and were examined by use of nonparametric signed rank tests to determine whether the median difference was 0. The absolute value of the difference was also examined, Spearman rank-order correlation, a nonparametric measure of association, was used for the 2 methods to determine significant correlations between variables. The hot and cold sphere phantom studies demonstrated that WBR had improved contrast recovery and slightly better background uniformity than did the ordered-subsets expectation maximization. The cardiac phantom studies performed with attenuating medium and background activity showed that the half-scan time images processed with WBR had better contrast recovery and background uniformity than did the full-scan time FBP reconstruction. In the clinical studies, highly significant correlations were observed between WBR and FBP for functional as well as perfusion variables (P<.0001). The summed stress score, summed rest scores, and summed difference score were not statistically different for FBP and WBR (P<.05). Left ventricular volumes had a high correlation coefficient but were significantly larger with FBP than with WBR.

Conclusion

Our study results suggest that cardiac single photon emission computed tomography perfusion studies may be performed with the WBR algorithm using half of the scan time without compromising qualitative or quantitative imaging results.

Key Words

Single photon emission computed tomography wide beam reconstruction filtored backprojection 

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References

  1. 1.
    Taillefer R, Primeau M, Costi P, Lambert R, Leveille J, Latour Y, Technetium-99m-sestamibi myocardial perfusion maging comparison between a short (8 minutes) and standard (21 minutes) data acquistion time in diagnosis of coronary artery disease [abstract] J Nucl Med 1992;33:855.Google Scholar
  2. 2.
    DePuey EG, Nichols KJ, Slowikowski JS, Scarpa WJ Jr, Smith CJ, Melancon S, et al. Fast stress and rest acquisitions for technetium-99m-sestamibi separate-day SPECT. J Nucl Med 1995;36:569–74.PubMedGoogle Scholar
  3. 3.
    Shepp LA, Vardi Y. Maximum likelihood reconstruction for emission tomography. IEEE Trans Med Imaging 1982;1:113–22.PubMedCrossRefGoogle Scholar
  4. 4.
    Lange K, Carson R. EM reconstruction algorithms for emission and transmission tomography. J Comput Assist Tomogr 1984;8: 306–16.PubMedGoogle Scholar
  5. 5.
    Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imaging 1994;13:601–9.PubMedCrossRefGoogle Scholar
  6. 6.
    Tsui BMW, Hu HB, Gilland DR, Gullberg GT. Implementation of simultaneous attenuation and detector response correction in SPECT. IEEE Trans Nucl Sci 1988;35:778–83.CrossRefGoogle Scholar
  7. 7.
    Hutton BF, Lau YH. Application of distance-dependent resolution compensation and post-reconstruction filtering for myocardial SPECT. Phys Med Biol 1998;43:1679–93.PubMedCrossRefGoogle Scholar
  8. 8.
    Bouwens LR, Gifford H, Van de Walle R, King MA, Lemahieu I, Dierckx RA. Resolution recovery for list-mode reconstruction in SPECT. Phys Med Biol 2001;46:2239–53.PubMedCrossRefGoogle Scholar
  9. 9.
    Vija H, Hawman EG, Engdahl JC. Analysis of a SPECT OSEM reconstruction method with 3D beam modeling and optional attenuation correction: phantom studies. Conference record, IEEE MIC, 2003.Google Scholar
  10. 10.
    DePuey EG. Imaging guidelines for nuclear cardiology procedures. 2006;13:e21-171.Google Scholar
  11. 11.
    Metz CE, Atkins FB, Beck RN. The geometric transfer function component for scintillation camera collimators with straight parallel holes. Phys Med Biol 1980;25:1059–70.PubMedCrossRefGoogle Scholar
  12. 12.
    Gonzalez RC, Woods RE. Digital image processing. Upper Saddle River (NJ): Prentice Hall: 2002.Google Scholar

Copyright information

© American Society of Nuclear Cardiology 2007

Authors and Affiliations

  • Salvador Borges-Neto
    • 1
    • 2
  • Robert A. Pagnanelli
    • 1
  • Linda K. Shaw
    • 2
  • Emily Honeycutt
    • 2
  • Shuli C. Shwartz
    • 3
  • George L. Adams
    • 1
    • 2
  • Ralph Edward Coleman
    • 1
  1. 1.Department of Radiology, Division of Nuclear MedicineDuke Univerisity Medical CenterDurham
  2. 2.Department of Internal Medicine, Division of CardiologyDuke University Medical CenterDurham
  3. 3.UltraSPECTHaifaIsrael

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