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Journal of Nuclear Cardiology

, Volume 14, Issue 4, pp 514–520 | Cite as

Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans

  • Hsiao D. Lieu
  • John C. Shryock
  • Gregory O. von Mering
  • Toufigh Gordi
  • Brent Blackburn
  • Ann W. Olmsted
  • Luiz Belardinelli
  • Richard A. Kerensky
Original Articles

Abstract

Background

Regadenoson is a selective A2A adenosine receptor agonist and vasodilator used to increase the heterogeneity of distribution of coronary blood flow during myocardial perfusion imaging. This study characterized the dose dependence of regadenoson-induced coronary hyperemia.

Methods and Results

An open-label, dose-escalation study of regadenoson (10–500μg, rapid intravenous bolus) was performed in 34 subjects; in 4 additional subjects, the effect of aminophylline to reverse the response to regadenoson was determined. Intracoronary peak blood flow velocity in either the left anterior descending or left circumflex artery was measured by continuous Doppler, signal recording, heart rate, central aortic blood pressure, and adverse effects were recorded. Regadenoson increased peak blood flow velocity by up to 3.4-fold in a dose-dependent manner. The mean duration of the increase in flow velocity of 2.5-fold or greater caused by 400 to 500 μg of regadenoson was 2.3 to 2.4 minutes. Regadenoson (400–500 μg) increased heart rate by up to 21±6 beats/min and decreased systolic blood pressure (−5±8 mm Hg to −24±16 mm Hg) and diastolic blood pressure (−8±4 mm Hg to −15±14 mm Hg). Aminophylline (100 mg) attenuated the increase in peak flow velocity but not tachycardia caused by 400 μg of regadenoson.

Conclusion

The results of this study demonstrate the utility of regadenoson as a coronary vasodilator for myocardial perfusion imaging.

Key Words

Regadenoson coronary flow velocity myocardial perfusion imaging A2A adenosine Doppler pharmacologic stress agent 

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Copyright information

© American Society of Nuclear Cardiology 2007

Authors and Affiliations

  • Hsiao D. Lieu
    • 1
  • John C. Shryock
    • 2
  • Gregory O. von Mering
    • 3
  • Toufigh Gordi
    • 4
  • Brent Blackburn
    • 2
  • Ann W. Olmsted
    • 2
  • Luiz Belardinelli
    • 2
  • Richard A. Kerensky
    • 5
  1. 1.Portola PharmaceuticalsSouth San Francisco
  2. 2.CV TherapeuticsPalo Alto
  3. 3.Division of Cardiology, College of MedicineUniversity of FloridaGainesville
  4. 4.DepomedMenlo Park
  5. 5.Archbold Medical CenterThomasville

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