Journal of Nuclear Cardiology

, Volume 14, Issue 2, pp 194–199 | Cite as

Estimation of coronary flow reserve by sestamibi imaging in type 2 diabetic patients with normal coronary arteries

  • Giovanni Storto
  • Teresa Pellegrino
  • Ann Rita Sorrentino
  • Luca Luongo
  • Mario Petretta
  • Alberto Cuocolo
Original Articles

Abstract

Background

We assessed coronary flow reserve (CFR) by sestamibi imaging in patients with type 2 diabetes without coronary artery disease and normal coronary vessels.

Methods and Results

Dipyridamole/rest technetium 99m sestamibi imaging was performed in 33 patients with type 2 diabetes without a history of coronary artery disease and normal coronary vessels at angiography and in 12 control subjects. Myocardial blood flow (MBF) was estimated by measuring first-transit counts in the pulmonary artery and myocardial counts from tomographic images. Estimated CFR was expressed as the ratio of stress MBF to rest MBF. Rest MBF and CFR were corrected for rate-pressure product and expressed as normalized MBF and normalized CFR. At rest, estimated MBF and normalized MBF were not different in control subjects versus patients (0.98±0.4 counts·pixel−1·s−1 vs 1.42±0.9 counts·pixel−1·s−1 and 1.14±0.5 counts·pixel−1·s−1 vs 1.61±0.9 counts·pixel−1·s−1, respectively). Conversely, stress MBF was higher in control subjects than in patients (2.34±0.8 counts·pixel−1·s−1 vs 1.55±0.8 counts·pixel−1·s−1, P<.01). Thus estimated CFR was higher in control subjects than in patients (2.40±0.3 vs 1.36±0.8, P<.0001). After correction for the rate-pressure product, normalized CFR was still higher in control subjects than in patients (2.10±0.5 vs 1.28±0.8, P<.001).

Conclusions

Sestamibi imaging may detect impaired coronary vascular function in response to dipyridamole in type 2 diabetic patients withou a history of coronary artery disease and with normal coronary arteries.

Key Words

Coronary flow reserve type 2 diabetes mellitus single photon emission computed tomography imaging 

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Copyright information

© the American Society of Nuclear Cardiology 2007

Authors and Affiliations

  • Giovanni Storto
    • 4
    • 2
  • Teresa Pellegrino
    • 3
  • Ann Rita Sorrentino
    • 4
  • Luca Luongo
    • 4
  • Mario Petretta
    • 1
  • Alberto Cuocolo
    • 4
    • 2
    • 3
  1. 1.Department of Clinical Medicine, Cardiovascular and Immunological SciencesUniversity Federico IINaplesItaly
  2. 2.Institute of Biostructure and BioimagesNational Council of ResearchNaplesItaly
  3. 3.Institute of Diagnostic and Nuclear DevelopmentSDN FoundationNaplesItaly
  4. 4.Department of Biomorphological and Functional SciencesUniversity Federico IINaplesItaly

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