Journal of Nuclear Cardiology

, Volume 13, Issue 6, pp e80–e90

Stress protocols and tracers

  • Milena J. Henzlova
  • Manuel D. Cerqueira
  • John J. Mahmarian
  • Siu-Sun Yao

Suggested Reading

  1. 1.
    Abbott BG, Afshar M, Berger AK, Wackers FJT. Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging. J Nucl Cardiol 2003;10:9–16.PubMedCrossRefGoogle Scholar
  2. 2.
    Amanullah AM, Berman DS, Erel J, et al. Incremental prognostic value of adenosine myocardial perfusion single-photon emission computed tomography in women with suspected coronary artery disease. Am J Cardiol 1998;82:725–30.PubMedCrossRefGoogle Scholar
  3. 3.
    Amanullah AM, Berman DS, Hachamovitch R, et al. Identification of severe or extensive coronary artery disease in women by adenosine technetium-99m sestamibi SPECT. Am J Cardiol 1997;80:132–7.PubMedCrossRefGoogle Scholar
  4. 4.
    Aqel RA, Zoghbi GJ, Trimm JR, Baldwin SA, Iskandrian AE. Effect of caffeine administered intravenously on intracoronaryadministered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 2004;93:343–6.PubMedCrossRefGoogle Scholar
  5. 5.
    Berman DS, Kiat H, Friedman JD, et al. Separate acquisition rest thallium-201/stress technetium-99m sestamibi dual-isotope myocardial perfusion single-photon emission computed tomography: a clinical validation study. J Am Coll Cardiol 1993;22:1455–64.PubMedGoogle Scholar
  6. 6.
    Braat SH, Leclercq B, Itti R, Lahiri A, Sridhara B, Rigo P. Myocardial imaging with technetium-99m-tetrofosmin: comparison of one-day and two-day protocols. J Nucl Med 1994;35:1581–5.PubMedGoogle Scholar
  7. 7.
    Candell-Riera J, Santana-Boado C, Castell-Conesa J, et al. Simultaneous dipyridamole/maximal subjective exercise with Tc-99m- MIBI SPECT: improved diagnostic yield in coronary artery disease. J Am Coll Cardiol 1997;29:531–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Cerqueira MD, Verani MS, Schwaiger M, Heo J, Iskandrian AS. Safety profile of adenosine stress perfusion imaging: results from Adenoscan Multicenter Trial Registry. J Am Coll Cardiol 1994;23:384–90.PubMedGoogle Scholar
  9. 9.
    Dakik HA, Wendt JA, Kimball K, Pratt CM, Mahmarian JJ. Prognostic value of adenosine Tl-201 myocardial perfusion imaging after acute myocardial infarction: results of a prospective clinical trial. J Nucl Cardiol 2005;12:276–83.PubMedCrossRefGoogle Scholar
  10. 10.
    Eagle KA, Berger PB, Calkins H, et al. ACC/AHA guideline update on perioperative cardiovascular evaluation for noncardiac surgery. American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Peroperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation 2002;105:1257–67.PubMedGoogle Scholar
  11. 11.
    Elliott MD, Holly TA, Leonard SM, Hendel RC. Impact of an abbreviated adenosine protocol incorporating adjunctive treadmill exercise on adverse effects and image quality in patients undergoing stress myocardial perfusion imaging. J Nucl Cardiol 2000;7:584–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Gibbons RJ, Balady GJ, Bricker JT, et al. ACC/AHA 2002 guideline update for exercise testing: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). Circulation 2002;106:1883–92.PubMedCrossRefGoogle Scholar
  13. 13.
    Hays JT, Mahmarian JJ, Cochran AJ, Verani MS. Dobutamine thallium-201 tomography for evaluating patients with suspected coronary artery disease unable to undergo exercise or vasodilator pharmacologic stress testing. J Am Coll Cardiol 1993;21:1583–90.PubMedGoogle Scholar
  14. 14.
    Higley B, Smith FW, Smith T, et al. Technetium-99m-1,2 bis[bis(2-ethoxyethyl)phosphino]ethane: human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent. J Nucl Med 1993;34:30–8.PubMedGoogle Scholar
  15. 15.
    Holly TA, Satran A, Bromet DS, Mieres JH, Frey MJ, Elliott MD, et al. The impact of adjunctive adenosine infusion during exercise myocardial perfusion imaging: results of the Both Exercise and Adenosine Stress Test (BEAST) trial. J Nucl Cardiol 2003;10:291–6.PubMedCrossRefGoogle Scholar
  16. 16.
    Iskandrian AS, Verani MS, Heo J. Pharmacologic stress testing: mechanism of action, hemodynamic responses, and results in detection of coronary artery disease. J Nucl Cardiol 1994;1:94–111.PubMedCrossRefGoogle Scholar
  17. 17.
    Jain D. Technetium labeled myocardial perfusion imaging agents. Semin Nucl Med 1999;29:221–36.PubMedCrossRefGoogle Scholar
  18. 18.
    Jain D, Wackers FJTh, Mattera J, McMahon M, Sinusas AJ, Zaret BL. Biokinetics of technetium-99m-tetrofosmin: myocardial perfusion imaging agent: implications for a one day imaging protocol. J Nucl Med 1993;34:1254–9.PubMedGoogle Scholar
  19. 19.
    Jamil G, Ahlberg AW, Elliott MD, Hendel RC, Holly T, McGill CC, et al. Impact of limited treadmill exercise on adenosine Tc-99m sestamibi single-photon emission computed tomographic myocardial perfusion imaging in coronary artery disease. Am J Cardiol 1999;84:400–3.PubMedCrossRefGoogle Scholar
  20. 20.
    Kelley JD, Forster AM, Higley B, et al. Technetium-99mtetrofosmin a new radiopharmaceutical for myocardial perfusion imaging. J Nucl Med 1993;34:222–7.Google Scholar
  21. 21.
    Klodas E, Miller TD, Christian TF, Hodge DO, Gibbons RJ. Prognostic significance of ischemic electrocardiographic changes during vasodilator stress testing in patients with normal SPECT images. J Nucl Cardiol 2003;10:4–8.PubMedCrossRefGoogle Scholar
  22. 22.
    Lette J, Tatum JL, Fraser S, Miller DD, et al. Safety of dipyridamole testing in 73,806 patients: the Multicenter Dipyridamole Safety Study. J Nucl Cardiol 1995;2:3–17.PubMedCrossRefGoogle Scholar
  23. 23.
    Mahmarian JJ, Shaw LJ, Olszewski GH, Pounds BK, Frias ME, Pratt CM ; INSPIRE Investigators. Adenosine sestamibi SPECT postinfarction evaluation (INSPIRE) trial: a randomized, prospective multicenter trial evaluating the role of adenosine Tc-99m sestamibi SPECT for assessing risk and therapeutic outcomes in survivors of acute myocardial infarction. J Nucl Cardiol 2004;11:458–69.PubMedCrossRefGoogle Scholar
  24. 24.
    Mahmood S, Gunning M, Bomanji JB, et al. Combined rest thallium-201/stress technetium-99m-tetrofosmin SPECT: feasibility and diagnostic accuracy of a 90-minute protocol. J Nucl Med 1995;36:932–5.PubMedGoogle Scholar
  25. 25.
    Mieres JH, Shaw LJ, Arai A, Budoff MJ, Flamm SD, Hundley WG, et al. Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease. Circulation 2005;111:682–96.PubMedCrossRefGoogle Scholar
  26. 26.
    O’Keefe JH, Bateman TM, Handlin LR, Barnhart CS. Fourversus 6-minute infusion protocol for adenosine thallium-201 single photon emission computed tomography imaging. Am Heart J 1995;129:482–7.PubMedCrossRefGoogle Scholar
  27. 27.
    Pennell DJ, Mavrogeni S, Forbat SM, Karwatowski SP, Underwood SR. Adenosine combined with dynamic exercise for myocardial perfusion imaging. J Am Coll Cardiol 1995;25:1300–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Pennell DJ, Underwood SR, Ell PJ. Safety of dobutamine stress for thallium myocardial perfusion tomography in patients with asthma. Am J Cardiol 1993;71:1346–50.PubMedCrossRefGoogle Scholar
  29. 29.
    Pennell DJ, Underwood SR, Swanton RH, Walker JM, Ell PJ. Dobutamine thallium myocardial perfusion tomography. J Am Coll Cardiol 1991;18:1471–9.PubMedCrossRefGoogle Scholar
  30. 30.
    Samady H, Wackers FJTh, Joska TM, Zaret BL, Jain D. Pharmacologic stress perfusion imaging with adenosine: role of simultaneous low-level treadmill exercise. J Nucl Cardiol 2002;9:188–96.PubMedCrossRefGoogle Scholar
  31. 31.
    Stein RA, Chaitman BR, Balady GJ, et al. Safety and utility of exercise testing in emergency room chest pain centers: an advisory from the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association. Circulation 2000;102:1463–7.PubMedGoogle Scholar
  32. 32.
    Taillefer R. Radionuclide myocardial perfusion imaging protocols. In: Heller GV, Hendel RC, editors. Nuclear cardiology: practical applications. New York: McGraw-Hill Medical Publishing Division; 2004.Google Scholar
  33. 33.
    Taillefer R, Laflamme L, Dupras G, Picard M, Phaneuf DC, Leveille J. Myocardial perfusion imaging with 99mTc-methoxyisobutyl- isonitrile (MIBI): comparison of short and long time intervals between rest and stress injections. Preliminary results. Eur J Nucl Med 1988;13:515–22.PubMedCrossRefGoogle Scholar
  34. 34.
    Thomas GS, Prill NV, Majmundar H, Fabrizi RR, Thomas JJ, Hayashida C, et al. Treadmill exercise during adenosine infusion is safe, results in fewer adverse reactions, and improves myocardial perfusion image quality. J Nucl Cardiol 2000;7:439–46.PubMedCrossRefGoogle Scholar
  35. 35.
    Trueth MG, Reyes GA, He ZX, Cwaig E, Mahmarian JJ, Verani MS. Tolerance and diagnostic accuracy of an abbreviated adenosine infusion for myocardial scintigraphy: a randomized, prospective study. J Nucl Cardiol 2001;8:548–54.CrossRefGoogle Scholar
  36. 36.
    Vaduganathan P, He ZX, Raghavan C, Mahmarian JJ, Verani MS. Detection of left anterior descending coronary artery stenosis in patients with left bundle branch block: exercise, adenosine or dobutamine imaging. J Am Coll Cardiol 1996;28:543–53.PubMedCrossRefGoogle Scholar
  37. 37.
    Vitola JV, Brambatti JC, Caligaris F, Lesse CR, Nogueira PR, Joaquim AI, et al. Exercise supplementation to dipyridamole prevents hypotension, improves electrocardiogram sensitivity, and increases heart-to-liver activity ratio on Tc-99m sestamibi imaging. J Nucl Cardiol 2001;8:652–9.PubMedCrossRefGoogle Scholar
  38. 38.
    Wackers FJTh, Berman DS, Maddahi J, et al. Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med 1989;30:301–11.PubMedGoogle Scholar

Copyright information

© American Society of Nuclear Cardiology 2006

Authors and Affiliations

  • Milena J. Henzlova
  • Manuel D. Cerqueira
  • John J. Mahmarian
  • Siu-Sun Yao

There are no affiliations available

Personalised recommendations