Journal of Nuclear Cardiology

, Volume 13, Issue 5, pp 629–634 | Cite as

Accuracy of stress Tc-99m tetrofosmin myocardial perfusion tomography for the diagnosis and localization of coronary artery disease in women

  • Abdou Elhendy
  • Arend F. L. Schinkel
  • Ron T. van Domburg
  • Elena Biagini
  • Harm H. Feringa
  • Don Poldermans
  • Jeroen J. Bax
  • Roelf Valkema
Original Article
Received:
Accepted:

Abstract

Background

Earlier studies have suggested a modest accuracy of stress thallium 201 myocardial perfusion imaging (MPI) for the diagnosis of coronary artery disease (CAD) in women. The accuracy of stress MPI with technetium 99m tetrofosmin has not been studied in women. The aim of this study was to assess the accuracy of stress Tc-99m tetrofosmin MPI for the diagnosis and localization of CAD in women.

Methods and Results

We studied 88 women who underwent exercise or dobutamine stress Tc-99m tetrofosmin tomography and coronary angiography within 3 months. Significant CAD was defined as a stenosis 50% or greater in diameter in at least 1 major epicardial coronary artery. Myocardial perfusion abnormalities were detected in 44 of 53 patients with significant CAD and in 7 of 35 patients without significant CAD (overall sensitivity, 83% [95% confidence interval (CI), 73%-93%]; specificity, 80% [95% CI, 67%-93%]; and accuracy, 82% [95% CI, 74%-90%]). The sensitivity was 72% (18/25) in patients with single-vessel CAD and 93% (26/28) in patients with multivessel CAD. Perfusion abnormalities were detected in 2 or more vascular distributions in 20 of 28 patients with multivessel CAD and in 4 of 60 patients without multivessel CAD (sensitivity for the identification of multivessel CAD, 71% [95% CI, 55%-88%]; specificity, 93% [95% CI, 86%-98%]; and accuracy, 86% [95% CI, 79%-93%]). The sensitivity, specificity, and accuracy were 82%, 84%, and 83%, respectively, for the diagnosis of CAD in the left anterior descending artery; 77%, 84%, and 81%, respectively, for CAD in the right coronary artery; and 74%, 80%, and 78%, respectively, for CAD in the left circumflex artery.

Conclusion

Stress Tc-99m tetrofosmin MPI is an accurate noninvasive technique for the diagnosis and localization of CAD in women.

Key Words

Coronary artery disease Women myocardial perfusion radionuclide imaging 
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Copyright information

© American Society of Nuclear Cardiology 2006

Authors and Affiliations

  • Abdou Elhendy
    • 1
    • 2
  • Arend F. L. Schinkel
    • 1
  • Ron T. van Domburg
    • 1
  • Elena Biagini
    • 1
  • Harm H. Feringa
    • 1
  • Don Poldermans
    • 1
  • Jeroen J. Bax
    • 3
  • Roelf Valkema
    • 4
  1. 1.Marshfield
  2. 2.The Netherlands, and Marshfield ClinicMarshfield
  3. 3.University Hospital RotterdamRotterdam, and Leiden University HospitalLeiden
  4. 4.Department of Nuclear Medicine

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