Journal of Nuclear Cardiology

, Volume 12, Issue 6, pp 662–670 | Cite as

Incremental prognostic value of combined perfusion and function assessment during myocardial gated SPECT in patients aged 75 years or older

  • Olivier De Winter
  • Anja Velghe
  • Nico Van de Veire
  • Pieter De Bondt
  • Marc De Buyzere
  • Christophe Van De Wiele
  • Guy De Backer
  • Thierry C. Gillebert
  • Rudi A. Dierckx
  • Johan De Sutter



Perfusion and functional data obtained during gated single photon emission computed tomography (SPECT) have proven prognostic value in the middle-aged patient population. The aim of this study was to investigate whether perfusion and functional cardiac gated SPECT data have prognostic value in patients aged 75 years or older.

Methods and Results

We studied clinical and gated SPECT predictors of cardiac and all-cause death in 294 patients aged 75 years or older with known or suspected coronary artery disease who were referred for tetrofosmin cardiac gated SPECT imaging. Summed perfusion scores were calculated in a 17-segment model by use of commercially available software (4D-MSPECT). Left ventricular functional data were calculated by use of QGS gated SPECT software. The median age of the study population was 78 years (range, 75–91 years). There were 160 men (54%) and 134 women (46%). During a median follow-up of 25.9 months (range, 1.8–36 months), 47 patients (16%) died (27 cardiac deaths). In a multivariate Cox proportional hazards regression analysis, the summed rest score (±2 gain ± 8.0, P ± .009), transient ischemic dilatation index (±2 gain ± 6.3, P ± .012), and resting left ventricular ejection fraction (±2 gain ± 7.0, P ± .030) were independent predictors of all-cause death. The summed rest score (±2 gain ± 8.2, P ± .004) and resting end-systolic volume (±2 gain ± 13.7, P ± .005) were independent predictors of cardiac death.


This study showed that gated SPECT left ventricular functional data assessed during myocardial gated SPECT provide independent and incremental information above clinical and perfusion SPECT data for the prediction of cardiac and all-cause death in patients aged 75 years or older referred for myocardial SPECT imaging.

Key Words

Single photon emission computed tomography coronary artery disease 


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Copyright information

© American Society of Nuclear Cardiology 2005

Authors and Affiliations

  • Olivier De Winter
    • 1
  • Anja Velghe
    • 2
  • Nico Van de Veire
    • 3
  • Pieter De Bondt
    • 1
  • Marc De Buyzere
    • 3
  • Christophe Van De Wiele
    • 1
  • Guy De Backer
    • 4
  • Thierry C. Gillebert
    • 3
  • Rudi A. Dierckx
    • 1
  • Johan De Sutter
    • 3
  1. 1.Nuclear Medicine DivisionGhent University HospitalGhentBelgium
  2. 2.Departments of GeriatricsGhent University HospitalGhentBelgium
  3. 3.Departments of CardiologyGhent University HospitalGhentBelgium
  4. 4.Cardiac Rehabilitation CenterGhent University HospitalGhentBelgium

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