Journal of Nuclear Cardiology

, Volume 12, Issue 4, pp 410–417

Assessment of myocardial perfusion by dynamic N-13 ammonia PET imaging: Comparison of 2 tracer kinetic models

  • Aliasghar Khorsand
  • Senta Graf
  • Christian Pirich
  • Otto Muzik
  • Kurt Kletter
  • Robert Dudczak
  • Gerald Maurer
  • Heinz Sochor
  • Ernst Schuster
  • Gerold Porenta
Original Article

DOI: 10.1016/j.nuclcard.2005.04.002

Cite this article as:
Khorsand, A., Graf, S., Pirich, C. et al. J Nucl Cardiol (2005) 12: 410. doi:10.1016/j.nuclcard.2005.04.002

Abstract

Background

Measurement of myocardial blood flow (MBF) by dynamic nitrogen 13 ammonia (NH3) positron emission tomography (PET) uses tracer kinetic modeling to analyze time-activity curves. We compared 2 commonly used models with 2 compartments (2C) and 3 compartments (3C) for quantification of MBF and coronary flow reserve (CFR).

Methods and Results

Seventy-seven patients underwent NH3 PET at rest and during hyperemia. Time-activity curves for blood pool and myocardial segments were obtained from short-axis images of dynamic sequences. Model fitting of the 2C and 3C models was performed to estimate regional MBF. MBF values calculated by 2C and 3C models were 0.98 ± 0.31 mL · min-1 · g-1 and 1.11 ± 0.37 mL · min-1 · g-1, respectively, at rest (P <.0001) and 2.79 ± 1.18 mL · min-1 · g-1 and 2.46 ± 1.02 mL · min−1 · g−1, respectively, during hyperemia (P < .01), resulting in a CFR of 3.02 · 1.31 and 2.39 · 1.15 (P <.0001), respectively. Significant correlation was observed between the 2 models for calculation of resting MBF (r = 0.78), hyperemic MBF (r = 0.68), and CFR (r = 0.68).

Conclusion

Measurements of MBF and CFR by 2C and 3C models are significantly related. However, quantification of MBF and CFR significantly differs between the methods. This difference needs to be considered when normal values are established or when measurements obtained with different methods need to be compared.

Key Words

Positron emission tomography nitrogen 13 ammonia myocardial perfusion imaging coronary flow reserve 

Copyright information

© American Society of Nuclear Cardiology 2005

Authors and Affiliations

  • Aliasghar Khorsand
    • 1
  • Senta Graf
    • 1
  • Christian Pirich
    • 2
  • Otto Muzik
    • 3
  • Kurt Kletter
    • 2
  • Robert Dudczak
    • 2
  • Gerald Maurer
    • 1
  • Heinz Sochor
    • 1
  • Ernst Schuster
    • 4
  • Gerold Porenta
    • 5
  1. 1.Departments of CardiologyMedical Computer Sciences, Medical University of ViennaViennaAustria
  2. 2.Departments of Nuclear MedicineMedical Computer Sciences, Medical University of ViennaViennaAustria
  3. 3.Children’s Hospital of MichiganDetroit
  4. 4.Medical Computer SciencesMedical University of ViennaViennaAustria
  5. 5.RudolfinerhausViennaAustriae

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