Journal of Nuclear Cardiology

, Volume 12, Issue 3, pp 268–275 | Cite as

Relationship of transient ischemic dilation in dipyridamole myocardial perfusion imaging and stress-induced changes of functional parameters evaluated by Tl-201 gated SPECT

  • Guang -Uei Hung
  • Kung -Wei Lee
  • Ching -Pei Chen
  • Wan -Yu Lin
  • Kuang -Tao Yang
Original Articles

Abstract

Background

This study assessed whether transient ischemic dilation (TID) of the left ventricle is related to ischemic stunning, manifested by stress-induced decrease of left ventricular ejection fraction (LVEF) and worsening of wall motion, by use of dipyridamolestress and redistribution thallium 201 gated single photon emission computed tomography (SPECT).

Methods and Results

Ninety-two consecutive patients undergoing dipyridamole Tl-201 gated SPECT were included. Patients with a TID ratio in the highest quartile were defined as having TID. In patients with TID, end-diastolic volume (EDV) and end-systolic volume (ESV) were both significantly greater on dipyridamole-stress images than on redistribution images (P <.001). The degree of enlargement was much greater for ESV than EDV. In patients without TID, EDV and ESV were both decreased after stress (P <.001). Patients with TID had a lower mean LVEF on dipyridamole-stress images than on redistribution images (P <.001). Patients without TID had a higher mean LVEF on dipyridamole-stress images than on redistribution images (P <.001). Patients with TID had a significant worsening of global wall motion on dipyridamole-stress images than on redistribution images (P <.001), but patients without TID did not.

Conclusion

TID was significantly correlated with ischemic stunning, and the enlargement of ESV was an important factor resulting in TID.

Key Words

Transient ischemic dilation ischemic stunning thallium 201 gated single photon emission computed tomography dipyridamole 

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Copyright information

© American Society of Nuclear Cardiology 2005

Authors and Affiliations

  • Guang -Uei Hung
    • 1
  • Kung -Wei Lee
    • 2
  • Ching -Pei Chen
    • 2
  • Wan -Yu Lin
    • 3
  • Kuang -Tao Yang
    • 1
  1. 1.ChanghuaTaiwan
  2. 2.Division of Cardiovascular Medicine, Department of Internal MedicineChanghua Christian HospitalChanghuaTaiwan
  3. 3.Department of Nuclear MedicineTaichung Veterans General HospitalTaichungTaiwan

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