Journal of Nuclear Cardiology

, Volume 11, Issue 6, pp 733–743 | Cite as

Magnetic resonance molecular imaging with nanoparticles

  • Gregory M. Lanza
  • Patrick M. Winter
  • Shelton D. Caruthers
  • Anne M. Morawski
  • Anne H. Schmieder
  • Katherine C. Crowder
  • Samuel A. Wickline
From bench to imaging


Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomic descriptions to complicated phenotypic characterizations based on the recognition of unique cell surface biochemical signatures. Although originally the purview of nuclear medicine, molecular imaging is now a prominent feature of most clinically relevant imaging modalities, in particular magnetic resonance (MR) imaging. MR nanoparticulate agents afford the opportunity not only for targeted diagnostic studies but also for image-monitored site-specific therapeutic delivery, much like the “magic bullet” envisioned by Paul Erhlich 100 years ago. Combining high-resolution MR molecular imaging with drug delivery will facilitate verification and quantification of treatment (ie, rational targeted therapy) and will offer new clinical approaches to many diseases.


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Copyright information

© American Society of Nuclear Cardiology 2004

Authors and Affiliations

  • Gregory M. Lanza
    • 1
  • Patrick M. Winter
    • 1
  • Shelton D. Caruthers
    • 1
    • 2
  • Anne M. Morawski
    • 1
  • Anne H. Schmieder
    • 1
  • Katherine C. Crowder
    • 1
  • Samuel A. Wickline
    • 1
  1. 1.Division of CardiologyWashington University Medical SchoolSt Louis
  2. 2.Philips Medical Systems, ClevelandOhio

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